TWiM provides thoughts on providing better training for a non-academic career, and help celebrate Black in Microbiology Week with a 2023 paper by Ari Kozik, a co-founder of Black Microbiologists Association and Assistant Professor at the University of Michigan Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Become a patron of TWiM. Links for this episode Better t<a href= "https://www.nature.com/articles/s41564-023-0149

TWiM reviews how a coating of lipoproteins provides a stabilizing environment on the inner membrane of Bacillus subtilis spores, and a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track mediators of inflammation in the gastrointestinal tract Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Subscribe to TWiM (free) on Apple Podcasts, <a title= "TWiM on Google Podcasts" href=

TWiM discusses a dispute about whether the mycobiome plays a role in the development of cancer, and the structure and function of channels that are delivered to plant cells by pathogenic bacteria. Hosts: Vincent Racaniello, and Michael Schmidt. Become a patron of TWiM. Links for this episode Cancer microbes disputed (Carl Zimmer) Fungal mycobiome and cancer (Nature) <a href="https://www.nature.com/articles/s41586-023-

TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Become a patron of TWiM. Links for this episode Phages avoid tRNA-targeting host defenses (eLife) Sea phages Ac

TWiM reveals that the ice cream manufacturing environment harbors psychrotrophic bacteria, and identification of a deadly bacterial strain causing widespread deaths of newborns in Uganda. Hosts: Vincent Racaniello, Michael Schmidt, & Michele Swanson. Become a patron of TWiM. Links for this episode Pyschrotrophic bacteria in ice cream plants (Appl Environ Micro) Creamery pays fine for <a href= "https://www.justice.gov/opa/pr/blue-bell-creameries-ordered-pay-1725-million-cri

TWiM explains personalized aerosilized phage therapy for a chronic lung infection, and using the combination of antibiotic and a DNA molecule that binds alpha-gal to reduce S. aureus infection in vivo. Hosts: Vincent Racaniello and Michael Schmidt Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a <a href="http://www.patreon.com/mic

TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Become a patron of TWiM. Links for this episode Diet-microbe-host interaction in early life (Science) <a h

TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Guest: Mark O. Martin Subscribe to TWiM (free) on Apple P

From ASM Microbe 2023 in Houston, TWiM speaks with Mimi Goldschmidt about her remarkable career in microbiology which included training astronauts to safely bring moon rocks back to Earth. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin. Guest: Mimi Goldschmidt Become a patron of TWiM. Links for this episode Mimi Goldschmidt (Wikipedia) <a href="ht

TWiM highlights viral defense and counter-defense: cGAS mediated ubiquitination to counter infection, and viral sponges that sequester nucleotide signals to inactivate immunity. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Become a patron of TWiM. Links for this episode Ubiquitin-like conjugation by bacterial cGAS (Nature) Jumpin’ Jack Flash (<a href= "https:/

TWiM describes a potential connection between a bacterial protein that damages DNA, and human cancers, and how to synthesize antimicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Become a patron of TWiM. Links for this episode Colorectal cancer and E. coli (Nature) <

TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin. Subscribe to TWiM (free) on Apple Podcasts, Spot

TWiM investigates the high variability in the rate and amount of current production from microbial fuel cells, and how bacteria link their growth rate to external nutrient conditions via a protein that functions as a cellular rheostat. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson. Become a patron of TWiM. Links for this episode Variability in microbial fuel cells (Appl Environ Micro) <a href="https://pubmed.ncbi.nlm.nih.gov/35181417/" target= "_blank" rel="

TWiM reveals a new type of satellite virus that requires only phage tails for producing infectious virus particles, and that highly virulent plague bacteria differs from its innocuous enteric predecessor by its resistance to lysis by human complement. Hosts: Vincent Racaniello and Michael Schmidt. Subscribe to TWiM (free) on Apple Podcasts, Spotify, <a title= "TWiM on Google Podcasts" href= "https://www.google.com/podcasts?fe

TWiM reveals housefly dispersal of antimicrobial resistant bacteria, and a reproductive organ in squid linked to symbiotic bacteria.   <span style= "font-size: 12pt; font-family: Arial; color: rgb(51, 51, 51); background-color: transparent; font-weight: 400; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-variant

TWiM reveals quorum-sensing systems that regulate intestinal inflammation and permeability caused by P. aeruginosa, and how plasmids manipulate bacterial behavior through translational regulatory crosstalk. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Become a patron of TWiM. Links for this episode Quorum-sensing in the intestine (mBio) <a href="https://www.nc

TWiM presents a protocol for evolving caffeine-tolerant yeast by high school students in the home, and how predator-prey dynamics change when multiple bacteria grow together in biofilms. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Guest: Mark O. Martin Subscribe to TWiM (free) on A

TWiM explains the synthesis in bacteria of new energy-dense biofuels that can replace rocket and jet fuels, and the use of nanopore sequencing to improve diagnosis and treatment of patients with serious infections.   <span style= "font-size: 12pt; font-family: Arial; color: rgb(0, 0, 0); background-color: transparent; font-weight: 400; font-style:

TWiM explains how magnesium modulates cell division frequency of a soil bacillus, and killing of fungi by Acinetobacter baumannii via a Type VI DNase Effector. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, <a hre

TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses. Become a patron of TWiM. Links for this episode: Phage therapy against M. abscessus lung infection (Cell) Encapsulation of the septal cell wall <span style="font-weight: 400

TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by emai

On this episode of TWiM, we reveal widespread stop-codon recoding in bacteriophages that may regulate translation of lytic genes, and how Staphylococcus aureus inhibits Pseudomonas aeruginosa growth. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Become a patron of TWiM. Links for this episode Stop codon recoding in bacteriophages (Nat Micro) How S. aureus inhibits P. aeruginosa growth (J Bact) <a href="https://p

TWiM presents evidence that over half of human pathogenic diseases are impacted by climate change, and considers how a novel prokaryote discovered next to an underground stream illuminates the pathway to multicellularity. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Mark Martin. Become a patron of TWiM. Links for this episode Climate change and pathogenic diseases (Nat Climate Change) <a href="https://camilo-mora.github

TWiM reveals high rates of co-transformation of plasmids in E. coli overturns the clonality myth, and bacterial membrane vesicles as a novel strategy for extrusion of the antimicrobial bismuth in H. pylori. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin Links for this episode The myth of clonality (Sci Rep) Bacterial membrane vesicles extrude bismuth (mBio) Gastric acid levels

Mark Martin returns to TWiM to join the discussion of how to design a complex gut microbiome, and protection of protists from virus infection by intracellular bacterial symbionts. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Become a patron of TWiM. Links for this episode Design of a complex gut microbiome (Cell) <a h

TWiM reveals how to inactivate norovirus on formica surfaces, and how to achieve antibiotic resistance by suppression of a frameshift mutation in an essential gene. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Subscribe to TWiM (free) on Apple Podcasts, Spotify, <a title= "

TWiM explores the activation of natural product synthesis using CRISPR interference in Streptomyces, and how light/dark and temperature cycling modulate Electron Flow in Pseudomonas aeruginosa biofilms. Hosts: Vincent Racaniello, Michele Swanson, and Petra Levin Become a patron of TWiM. Links for this episode Activating natural product synthesis (Nucleic Acids Res) Light and temperature

TWiM presents a novel mucosal COVID-19 vaccine based on a bacteriophage capsid, and potentiation of C. difficile infection severity by the gut bacterial community. Become a patron of TWiM. Links for this episode: Bacteriophage based COVID-19 vaccine (mBio) Gut microbiome potentiates C. difficile disease (mBio) <a href= "https://www.microbe.tv/twim/twim-271-l

TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides. Become a patron of TWiM. Links for this episode Improving plastics production by Archaea (Appl Environ Micro) Biodegradability of PHA (Green Chem) What does tesla mean for an MRI and its magnet? (GE) <a href="https:

TWiM reviews discovery of a bacterium that is visible to the naked eye, and reversible resistance to bacteriophage by shedding of the bacterial cell wall. Become a patron of TWiM. Links for this episode A bacterium that is not a microbe (Science) Overwhelming microbial greatness (TWiM 261) Medical illustrator Kellie Holoski Bacteriophage resistance by shedding cell wall (Open Biol) Who came first, <a href= "https://ecoevocommunity.nature.com/posts/who-came-first-

TWiM discusses citizen science surveillance of drug-resistant Aspergillus in garden soil, and the mechanism of action of a copper dependent antibiotic. Become a patron of TWiM. Links for this episode Fanny Hesse (Microbial Menagerie) Citizen science surveillance of Aspergillus (App Envir Micro) Aspergillum (Wikipedia) DMDC, copper dependent antibiotic (Infect Immun) <a href="h

From ASM Microbe 2022 in Washington, DC, Heran joins TWiM to discuss her career and her work on the agent of tuberculosis, Mycobacterium tuberculosis. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Guest: Heran Darwin Become a patron of TWiM. Links for this episode Honey badger of pathogens (E

TWiM explains how spindle-shaped Archaeal viruses evolved from rod-shaped ancestors to package a larger genome, and transcriptional recording by CRISPR acquisition from RNA. Become a patron of TWiM. Links for this episode From rods to spindles (Cell) Spindle-shaped virus movie (Cell) Bacteria that record (Science) Transcriptional recording with CRISPR (Nature) <a href="https://www.microbe.tv/twim/twim-266-letters/" target

TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted by hydrophilins. Become a patron of TWiM. Links for this episode Phage and satellite antiviral systems (Cell Host Micro) Hydropilins promote desiccation tolerance (Cell Host Micro) Letters read on TWiM 265 TWiM Listener survey Music used on TWiM is composed and performed

TWiM reveals that the atypical antipsychotic quetiapine promotes multiple antibiotic resistance in E. coli, and treatment with Bifidobacterium lactis probiotic benefits patients with coronary artery disease. Become a patron of TWiM. Links for this episode: Antipsychotic promotes antimicrobial resistance (J Bact) Probiotic benefits patients with <span style="fon

TWiM explains the use of lavender oil to disrupt Listeria biofilms, and how treatment of catheters with liquid silicone reduces associated urinary tract infections. Become a patron of TWiM. Links for this episode Lavender oil prevents biofilms (Lett Appl Micro) Silicone-infused catheters reduce infection (eLife) Viable but not culturable (TWiM 179) Letters read on TWiM 263 TWiM

TWiM welcomes new host Petra, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion system that is essential for virulence of a variety of bacterial pathogens. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, <a href= "http://w

Mark returns to TWiM to join in a discussion of soil microbiota as game-changers in restoration of degraded lands, and discovery of a centimeter-long bacterium, the biggest yet discovered. Guest: Mark O. Martin Become a patron of TWiM. Links for this episode: Game-changing soil microbiota (Science) <span style="font-wei

In this food-centric TWiM, we reveal the microbiomes of carnivorous vulture bees and of Gala apples from all over the world. Become a patron of TWiM. Links for this episode Microbiome of vulture bees (mBio) Bees previously in TWiM 245 Microbiome of Gala apples (Envir Micro) Apple flower microbiome (mBio) TWiM Listener survey Music used on

Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis. Become a patron of TWiM. Links for this episode: Global bacterial antimicrobial resistance (Nat Micro) Cancer <a href= "https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative"

TWiM explains how bacterial symbionts regulate tick blood feeding activity, and the reasons why antibiotics exist. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitc

On this episode of TWiM, how phages prevent other phages from invading their hosts without blocking their own reproduction, and plastic-degrading potential of microbes across the Earth. Become a patron of TWiM. Links for this episode: Prophages encode phage-defense systems with cognate self-immunity (Cell Host Microbe) Pr

TWiM discusses antigenic variation within dengue virus serotypes, and an mRNA vaccine that induces antibodies against tick proteins and prevents transmission of the Lyme disease agent. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson Subscribe to TWiM (free) on iTunes, Google Podcasts, <a href=

TWiM reveals a study showing that positive interactions among bacteria are far more common than previously thought, and how acquisition of a single gene enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt Subscribe to TWiM (free) on <a href= "http://itunes.apple.com/us/podcast/this-week-in-microbiolo

Mark Martin returns to TWiM for a discussion of the observation that Gram’s stain does not cross the bacterial cytoplasmic membrane, and suppression of gingival inflammation and bone loss through host modulation caused by episymbiotic Saccharibacteria.  Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt Guest: Mark O. Martin</s

Petra Levin joins TWiM to tell three stories from her laboratory: how starvation induces shrinkage of the bacterial cytoplasm; plasticity of E. coli cell wall and how it influences antibiotic resistance across different environments; and induction of antibiotic resistance by Triclosan. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt Guest: Petra Levin Become a Patron of TWiM! Links for this episode

On this episode of TWiM, using colicins to ferry DNA into cells through an iron transporter, and construction of highly efficient microbial fuel cells that produce more electrical current than previously observed. Links for this episode: Colicins used to ferry DNA into cells (mBio) Highly efficient microbial fuel cells (Science) Silver assists fuel cells (Science)<

TWiM explores the role of biofilms in infection by coronaviruses, and development of a Shigella vaccine using outer membrane vesicles derived from Salmonella Become a patron of TWiM. Links for this episode Biofilms and coronaviruses (Appl Envir Micro) Outer membrane vesicle vaccine (Appl Envir Micro) TWiM Listener survey Music used on TWiM is composed and performed b

On this episode, an electrochemical scaffold that delivers safe doses of hypochlorous acid to treat wound infections in humans, and a method for sampling and monitoring bacteria and viruses on surfaces using plain paper stickers. Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt Links: E-scaffolds on TWiM 143 The EPS matrix (J Bac

TWiM reveals how temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts, and the intracellular localization of toxin-antitoxin proteins in E. coli. Become a Patron of TWiM! Links for this episode: Phage-pathogen conflicts (Science) A ‘Trap-Door’ Strategy for Mobile Element Escape (Front Micro)</sp

Mark Martin returns to TWiM to discuss ways to increase diversity in our field, and the discovery of Borgs, giant extrachromosomal elements with the potential to augment methane oxidation. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt Guest: Mark O. Martin Subscribe to TWiM (free) on iTunes, <a href="https://www.google

TWiM explores whether ‘rewilding’ is a way to get back our missing gut microbes, and failure of bacteriophage therapy due to the production of neutralizing antibodies. Become a patron of TWiM. Links for this episode Gut microbiota through an evolutionary lens (Science) You’re missing microbes (NY Times) There is no <a href= "https://www.nytimes.com/2014/11/02/opinion/sunday/

The TWiM folk explore disruption of a Burkholderia intracellular niche by a cell death program, and an increase in Brucella infectiousness after intracellular passage. Become a patron of TWiM. Links for this episode: Disrupting intracellular niche (mBio)

In this episode, how polysaccharides keep cyanobacteria afloat in the oceans so that they can carry out photosynthesis, and a symbiotic bacterium that protects honey bees from fungal infections. Become a Patron of TWiM! Links for this episode: Bacterial blooms and polysaccharides (eLife) Social life of cyanobacteria (eLife) Bacteria that

Foodie TWiM reveals that bacteria in human saliva are major components of Ecuadorian indigenous beers, and an unusual E. coli that produces atypical light cream-colored colonies in chromogenic agar. Become a patron of TWiM. Links for this episode: Saliva bacteria in indigenous beers (Peer J) Unusual behavior of E. coli ST59 (Appl Envir Micro) <a href="https

TWiM continues its food arc with an examination of the effect of peroxyacetic acid spray on the microbiome and sensory properties of beef, and explores asymmetry of the cell division machinery during sporulation. Links for this episode: Effect of peroxyacetic acid on beef (Appl Envir Micro) Peracetic acid sterilization (CDC) Different cuts of beef <span

TWiM reveals the microbiome of sourdough starter cultures, and discovery of a novel family of prokaryotic nanocompartments involved in the metabolism of sulfur. Become a patron of TWiM. Links for this episode Sourdough starter microbiomes (eLife) Prokaryotic nanocompartments (eLife) TWiM Listener survey Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. <span style="font-weight:

TWiM explains how Vibrio biofilms are dispersed by polyamine signals, and the induction of inappetence by respiratory virus infection which causes alteration of the gut microbiome. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, <span style="font-weight:

TWiM reviews aspirin modulation of Fusobacterium nucleatum, a microbe that has been associated with colorectal cancer, and Elio tells us ‘What are vaccines’, a talk he recently gave to members of his community. Become a patron of TWiM. Links for this episode: Elio’s What are Vaccines? (pdf) Jenner Museum Aspirin</sp

The TWiM team reviews how variants of P. aeruginosa survive antimicrobial treatment, and a decrease in the antimicrobial resistance of the gut microbiome in the presence of the fungus C. albicans. Become a patron of TWiM. Links for this episode: Phoenix colony variants of P. aeruginosa

Elio reveals his thoughts on the big themes of modern microbiology, followed by an analysis of the gut microbiome in patients with Parkinson’s disease. Become a patron of TWiM. Links for this episode: Parkinson’s disease gut microbiome (NPJ Parkinsons) Sequencing data as compositions (Bioinformatics) <span style="font-we

To celebrate ten years, TWiM asks former hosts and guests to provide their thoughts on how microbiology has contributed to our understanding of the microbial world. Links for this episode: Neisseria LINES up: TWiM #1 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected]

In this episode, hiring and training expectations for future biomedical life sciences faculty, and the roles of bacterial symbionts in deep-sea hydrothermal vent tubeworms. Become a patron of TWiM. Links for this episode: Expectations for life sciences faculty (Life Sci Edu) Academic career readiness assessment (UCSF)

In this episode, how DNA of giant viruses has contributed extensively to the genome of green algae, and inhibition of E. coli virulence by a metabolic product of arachidonic acid in the intestinal epithelium. Links for this episode: Giant viral DNA shapes genomes of green algae (Nature) James Van Etten Darwin’s Radio Arachidonic acid

The TWiM team reviews Salmonella colonization of three-dimensional miniature intestinal organs, and identification of a circadian clock in a non-photosynthetic prokaryote. Become a patron of TWiM. Links for this episode: Salmonella colonization of enteroids (mBio) Circadian clock in nonphotosynthetic prokaryote (Science) <

The TWiM team reviews the movie Jezebel, played against the background of the yellow fever epidemic of 1853 in New Orleans, and prokaryotic viperins, ancestors of the eukaryotic enzymes that synthesize antiviral molecules. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <a href=

TWiM explores the use of a bacterial protein to make highly conductive microbial nanowires, and how modulin proteins seed the formation of amyloid, a key component of S. aureus biofilms. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <a href= "http://twimshow.microbeworld.libsy

Mark Martin returns to TWiM for a discussion of a predatory bacterium appropriately named Vampirococcus lugosii, and Elio reveals how bacteria can be used on the International Space Station to efficiently extract rare earth elements in microgravity. Become a patron of TWiM. Links for this episode: Space Station biomining (Nat Comm) Reductive evolution in a <a href= "https://www.biorxiv.org/content

In this episode of TWiM, control of Campylobacter in raw chicken by zinc oxide nanoparticles in packaging material, and Salmonella enterica genomes from a16th century epidemic in Mexico. Become a patron of TWiM. Links for this episode: Zinc oxide nanoparticles in raw meat packing (Appl Env Micro) Campylobacter, an emerging <a href= "https://wwwnc.c

In this episode of TWiM, the hidden biochemical diversity in soil-dwelling Actinobacteria that could lead to a second Golden Era of antibiotic discovery, and structures of glideosome components reveals the mechanism of gliding in apicomplexan parasites. Become a patron of TWiM. Links for this episode: Cryptic or silent? (mBio) The Streptomyces <a

Ninecia and Chelsey, two of the founders of Black in Microbiology, join TWiM to discuss the goals of the organization, then we reveal survival of Deinococcus bacteria for 3 years in space, an experiment that addresses the panspermia hypothesis for interplanetary transfer of life. Guests:  Ninecia Scott and Chelsey Spriggs You can watch this episode at https://youtu.be/1o1hh0I4rio Subscribe to TWiM (free) on <a href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiolo

TWiM presents an episode for mycophiles: how bacteria disarm mushroom pathogens, and the role of the CARD9 protein in protective immunity against pulmonary cryptococcosis. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson Become a patron of TWiM. Links f

TWiM presents two unusual microorganisms, Erysipelothrix rhusiopathiae, heard by Elio in an episode of Doc Martin, and Roseomonas mucosa, which is being used to treat atopic dermatitis. Become a patron of TWiM. Links for this episode: Erysipelothrix rhusiopathiae Treating atopic dermatitis with R. mucosa <span style= "font-weigh

The TWiM team explores how delivery of an enzyme into competitor cells leads to synthesis of (p)ppApp, depletion of ATP, deregulation of metabolic pathways, and cell death, and a refinement of our typical view of bacterial lag phase as a period of nonreplication. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt Become a patron of TWiM. Links for this episode: Killing competitors by <a href= "https://www.nature.com/

The TWiM team reveals the genetic mysteries of the Dead Sea Scrolls from sequencing of DNA, and 100 million year old living bacteria recovered from marine sediments. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Become a patron of TWiM. Links for this episode: Elio’s Memoirs <span style= "f

The TWiMmers explore detection of SARS-CoV-2 on surfaces in an ophthalmology examination room, the ability of stressed populations of Yersinia bacteria to survive antimicrobial treatment within host tissues, and how volatile organic chemicals produced by soil microbes attract arthropods which in turn disperse bacterial spores. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts<span style="font-weight

Mark Martin joins TWiM to describe nano-sized parasitic bacteria that inhabit humans, and the construction of whole-cell biosensors for detecting arsenic in drinking water. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts<span style="font-

TWiM reveals a potential mucus-busting weapon for patients with cystic fibrosis, and bacteria in the intestinal tract that can oxidize cholesterol, leading to lower levels of the lipid in blood. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <a href= "http://twimshow.microbewor

TWiM reveals that methane-producing bacteria might survive beneath the surface of Mars, and identification of a cytopathogenic toxin in a bacterium associated with preterm birth. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Become a <s

The TWiM discusses eradicating racism in academia and STEM, and a peptide from commensal bacteria that protects skin from damage caused by MRSA Become a patron of TWiM Links for this episode: Responsibility in academic research Improving equity in faculty hiring (MBoC) <span style= "font-weight:

The TWiM team explains how breathing can transmit SARS-CoV-2, and how lack of breathing leads to loss of mitochondria in a multicellular parasitic animal. Become a patron of TWiM. Links for this episode: Reducing transmission of SARS-CoV-2 (Science) Why social distancing <span style="f

The TWiM team explains an experimental vaccine to prevent E. coli urinary tract infections, and the remarkable three-way symbiosis of narnaviruses, bacteria, and fungi. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <span s

The TWiM team discuses saliva as more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swab and how Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough. Links for this episode: Preventing the next pandemic (NY Times) COVID-19 treatment guidelines (NIH) Saliva sensitive <spa

A ferret model for infection by SARS-CoV-2, and how Neolithization lead to emergence of a human bacterial pathogen. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Links for this episode: Infection and transmission of SARS-CoV-2 in ferrets (Cell Host Micr) <li style="font-

Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response. ASM COVID-19 Summit Value of SARS-CoV-2 diagnostic testing (mBio) How SARS-CoV-2 is changing (nextstrain) <span style= "font-weight: 400;

Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect. Links for this episode: Human coronavirus 229E infectivity on common surfaces (mBio) Aerosol and surface stability of SARS-CoV-2 (medRxiv) Peptidoglycan synthesis by a <a href= "https://www.ncbi.nlm.nih.gov/pubmed/315

The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease.  2019-nCoV case tracking (JHU) Clinical features of infection with 2019-nCoV (Lancet) Early transmission dynamics of 2019-nCoV (

The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples. Become a patron of TWiM. Links for this episode: Colorectal cancer and the gut microbiome (PNAS) Fire blight <span style= "font-weig

The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Subscribe to TWiM (free) on Apple Podcasts<span style=

The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane. Become a patron of TWiM. Links for this episode: Ribosome modification resuscitates persister cells (Environ Micro) Flagellotrophic phage targets host with tail

Hosts: Vincent Racaniello, Michele Swanson and Michael Schmidt Guests: Deanna Beatty, Mark Hay, Gina Lewin<span style= "font-weight

From ASM Microbe 2019 in San Francisco, Vincent speaks with Victoria McGovern, Carl Nathan, and Dan Portnoy about advancing human health through innovative collaborations. Host: Vincent Racaniello Guests: Victoria McGovern, Carl Nathan, and Dan Portnoy Links for this episode: Getting grants (Virulence) Nitric oxide synthase pro

The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts. Become a patron of TWiM. Links for this episode: <a href= "https://email.labxmediagroup.com/e2t/c/*W8WZcdW1WRSsHN3Gmn3qcdzS80/*W8-BRKf80hr1QW2_KJFX58mGPR0/5/f18dQhb0SfHp9dZyGFW6JqYCP4T_wDdW3N1L548rBKmMVsd5m31SddPTW53DQ4N7s5LskW2Kpnd555pcfDW8W1FWc2NTNt9W4dQby47rCZxhVq5cDs8Xlj7kW2MyQC72KWWrsW7qTBq34LlS4KW8W23m_4hXX6wW4M4BzG5lKqHdW7NQH2W57TP8JW5rC5-K3pW6wtW2shC385mNLNvW7bqTzM7vp5SXW5hT5m12CJYd0W35_0J97W3wBDW7Vkr3k5TDqB9W2sNX1z6RM55jW5ZpycS57-ZBTW83C5JP6rY-3sW2KQ2YY1Gk5btW360lT36pkGp4W3m2hkS2LGsc9W52Yl

The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell. Links for this episode: Tardigrades on the moon (Mashable) Meet the Tardigrade (WaPo) <li style="font-w

Host: Vincent Racaniello Guests: Nicholas Arpaia and Tal Danino Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice. Links for this episode: Programmable bacteria induce tumor immunity (Nat Med) <span style= "font-w

The TWiM team reveals thousands of small novel genes in the human microbiome, and a mutualistic symbiosis between marine protists covered with magnetosome-containing bacteria. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Links for this episode Thousands of small novel genesin human microbiome (Cell) A magnetotactic consortiumunder the sea (Nat Micro) <a href= "https://twitter.com/DEEMteam_Orsay/status

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Guest: Julie Wolf Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction,

Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students. Become a patron of TWiM. Links for this episode: Paradigm shifts, paradigm drifts (pdf) Introducing THOR (mBio) <a href= "https://www.ncbi.nlm.n

Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms. VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, A

From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review. Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt Guests: Susanna L. Harrisand Alex Politis Subscribe to TWiM (free) on <a href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-micr

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, <a href="

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components. Become a patron of TWiM. Links for this episode: Take the TWiM listener survey Bacteria store energy for <a href= "https://urldefense.proofpoint.com/v2/url?u=https-3A__www.pnas.org_content_early_2019_04_03_1818995116&d=DwMCaQ&c=G2MiLlal7SXE3PeSnG8W6_JBU6FcdVjSsBSbw6gcR0U&r=o4snVIQZ0CVuLGpZvqFOP4ToVfgjBKFWQW4Gx6mIfA4&m=4MaH5NPJDDMcmW3z62w6J9O20xbrS590c9mrqDHRXC8&s=Aqya6

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function. Links for this episode: Ambrosia beetles, ethanol, and farmed fungi (PNAS) Cleaved cochlin protects the inner ear (Cell Host Microbe) Importance of <a href= "https://www.ada.org/en/press-room/news-releases/2016-archive/august/statement-from-the-american-dental-association-ab

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <span style= "font-weight: 400

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli. Become a patron of TWiM. Links: Please take the TWiM listener survey Bacteria help dengue virus in mosquito gut (Cell Host Micr) Fungus helps dengue virus in mosquito gut (TWiV 479) <a href="https://www.ncbi.nlm.nih.gov/pubmed/302

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitc

The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny. Please take the TWiM listener survey Vote for NJ State Microbe Huge fungus is 2500 years old (Proc Roy Soc B) <a href= "https://en.wikip

The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria. Hosts: Vincent Racaniello, Elio Schaechter,  Michael Schmidt,  and Michele Swanson Subscribe to TWiM (free) on <a href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.co

The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, <a title= "TWiM on Google Podcasts" href= "

The TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses. Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson Take our listener survey. Thanks! asm.org/twimpoll Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noope

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome. Hosts: Vincent Racaniello and Michael Schmidt Links for this episode Antibiotics for gram-positives that kill gram-negatives (J Med Chem) Sideromycin commentary (Am Council Sci Health) Bacterial genome with DNA and RNA (J Am Chem Soc)

The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on iTunes, <a href= "https://www.go

The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, <

The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, <a title= "TWiM on Android" href= "http://subscrib

Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University. Host: Vincent Racaniello Guest: Sam Sternberg  Become a Patron of TWiM! Links for this episode Sternberg Laboratory at Columbia Mechanism of substrate selection by Cas9 (RNA) DNA interrogation by Cas9 (Nature) Conformational control of DNA target cleavage by Cas9 (Nature) A Crack in Cr

The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas. Become a patron of TWiM. Links for this episode: Parasitoid bacterium of protist (bioRxiv) Fungal symbiont recruitment <span style="font-weight: 4

The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake. Become a Patron of TWiM! Links for this episode: Legionnaire’s Disease with Michele Swanson Antibiotic susceptibility in less than 30 min (PNAS) <li styl

Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows. Host: Vincent Racaniello Guest: John Warhol Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" tar

Vincent speaks with Mark O. Martin about microbial centricity, teaching undergraduates microbiology, lux art, painting with glowing bacteria, tardigrades and much more at ASM Microbe 2018. Host: Vincent Racaniello Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" t

The TwiModulators discuss aerosolization of bacteria and viruses in an ocean-atmosphere mesocosm, and how the common practice of decontaminating produce with chlorine produces viable but non-culturable pathogens. Become a patron of TWiM. Links for this episode: Taxon-specific aerosolization of bacteria and viruses (Nat Commun) Chlorine produces <a href= "http://mbio.asm.org/content/9/2/e00540-18"

The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology. Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson Guest: Christina Kellogg Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast

The TWiM team discuss bacteriophage evolution in a dairy plant, and killing of less fit cells among social microbes. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href= "http://s

Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subscribe to TWiM" href= "http://twimshow.mi

The TWiM team notes the passing of Allan Campbell, and explains how aminoglycoside antibiotics like neomycin enhance host resistance to viral infection. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href= "http:

The TWiMsters explain why untreatable typhoid fever might be on the way, and the evolution of fungal virulence in tropical frogs. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_b

The Masters of the Microbiological Universe discuss the humongouest fungus, and a commensal bacterium that protects against skin neoplasia. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&l

The TWiMmers discuss culture-independent discovery of malacidin antibiotics, and unfolding of relaxase during bacterial conjugation. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" ta

The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subscribe

The TWiM team reveals that spread of plague was likely by human ectoparasites, not rats, and deconstruct a durable, broadly protective protein nanoparticle influenza virus vaccine. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Become a patron of TWiM. Links for this episode <li dir="ltr" sty

The cast of TWiM reveals how uropathogenic E. coli use a copper-binding protein to treat copper as a nutrient or a toxin, and Antarctic soil bacteria that survive on trace atmospheric gases. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/p

Dickson joins the TWiM team to discuss the nasal microbiota of dairy farmers, and attenuation of bacterial virulence by quorum sensing in the maize weevil. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Guest: Dickson Despommier Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href=

How pandemic influenza viruses suppress immunogenic cell death, and 3D printing of bacteria into functional materials.

Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater. Hosts:  Vincent Racaniello and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subscribe to TWiM"

The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Links for this episode: Reducing bacteria on exercise weights with copper (Am J Inf Contr) <span style= "font-weight: 400

From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria. Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang Watch the video version! https://www.youtube.com/watch?v=ifGCe-qfnA0 Become a patron of TWiM. Links for this episode:</spa

This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation. Links for this episode: Genes for the Streptococcus pyogenes fitness in human saliva (mSphere) Swallowed bacteria drive colonic inflammation (Science) Intestinal inflammation induced by oral bacteria (Science) <span style=

The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2

From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blan

The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subscribe to TWiM" h

The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.

The TWiM team considers a report on prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iPhone, <a title= "TWiM o

The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection. Hosts:  Vincent Racaniello, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noop

The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iPhone, <a titl

Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iPh

At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Watch the video version recorded live at ASM Microbe 2017! Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1

The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from latent reservoirs. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week

The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subscribe

The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iPhone, Android, <a title= "Subs

In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that Ureaplasma species can cause a system metabolic disturbance, hyperammonemia. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and <a href= "http://www.med.umich.edu/microb

The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Special guest: Pat Schloss Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332

Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Subscribe to TWiM (free) on iPhone, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynp

The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation. Hosts:  Vincent Racaniello, Michele Swanson, Michael Schmidt, and Elio Schaechter. Links for this episode Phosphate needed for Cryptococcus brain disease (mSphere) <li dir="ltr"

Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/"

Host: Vincent Racaniello Guest: Robert Heinzen At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, Coxiella burneti.   Become a Patron of TWiM! Links for this episode Rocky Mountain Laboratory Heinzen Laboratory Small town, big science (<a href= "ht

Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower. Become a patron of TWiM. Links for this episode: ASM Biothreats 2017 Rocky Mountain Laboratory BARDA

The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiolog

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Right click to download TWiM#143 (32 MB .mp3, 66 minutes). Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1http

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness. Hosts:  Vincent Racaniello, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity. Hosts:  Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Guest: Jennifer Bomberger Subscribe to TWiM (free) on iTunes, <a title="TWiM on Stitcher" href= "http://www.stit

Host: Vincent Racaniello Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.   Subscribe to TWiM (free) on iTunes, Stitcher, Android

The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, <a title="TWiM on Stitcher" href= "htt

The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Sub

Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Subscribe to TWiM" h

Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Subscribe to TWiM" href= "http://twimshow.microbewo

Links for this episode Dysbiosis of microbiome in critical illness (mSphere) Consequences of sewage spill into aquatic environment (App Env Mic) EPA recreational water guidelines (pdf) VRE following sewage spill (Outbreak Radio) FAQ: Human microbiome American gut project British gut project <a href= "https://www.ted.com/talks/rob_

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Subscribe to

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by <a title="Sub

Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires. Hosts: Vincent Racaniello, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank"

Hosts: Vincent Racaniello and Michael Schmidt Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.   Links for this episode Protein secretion in E. coli (J Bacteriol) Plague pathogenesis (J Bacteriol) Reversal of <a href= "http://www.scienc

Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele. Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.  Subscribe to TWiM (free) on iTunes, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/po

A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode. Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts. Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt. Subscribe to TW

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease. Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt. <a class="jcepopup" href= "images/stories/TWiM/snowblower_vent800.jpg" target="_blank" type= "image" data-mediabox= "title[Photograph of the ‘Subway’ snowbl

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by <a

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" targ

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Guest: Harris Wang Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells. Subscribe to TWiM (free) on iTunes, Stitcher<

Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Identification of a novel <a hre

Host: Vincent Racaniello Special guests: Rebekah Kading and Wyndham Lathem From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="TWiM on Android" href="http://subscribeonand

Hosts: Vincent Racaniello and Elio Schaechter. Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease. Subscribe to TWiM (free) on iTunes, Stitcher, Android, <a title="Subscribe to TWiM" href="http://twimshow

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis. Subscribe to TWiM (free) on iTunes, Stitcher, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" tar

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers. Subscribe to TWiM (free) on iTunes, Stitcher, Android, <a title="Subscribe to TWiM"

The TWiM team marvels over the finding of a completely nitrifying Nitrospira, and horizontal gene transfer from Wolbachia into an animal genome. Links for this episode: Complete nitrification by Nitrospira bacteria (Nature one, two) <

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans. Links for this episode  Bee cultivates fungus to survive (Curr Biol) Diet reduces C. albicans gut colonization (mSphere) mSphere, a new open-access ASM journal <a href="https:

Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells. Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!

Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the laboratory has advanced the science and teaching of microbiology, and discuss faculty work on uropathogenic E. coli, induction of stress by bacterial infection, and the gut microbiome. Visit microbeworld.org/twim for more including the special video version of this episode.

Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation sequencing and advanced molecular diagnostics. Visit microbeworld.org/twim to watch the video version and for complete shownotes including links mentioned.

The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus. Image: Lesion formation on banana surfaces infected with Aspergillus terreus. Source Links mentioned:   ASM Undergraduate Research Capstone Program ASM Undergraduate Fellowship Program Regulation of terrein production in Aspergillus terreus Visit <a href="http:

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron. Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id4223

The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile. Subscribe to TWiM (free) on iTunes, Stitcher, Android, <a style="color: rgb(77, 167, 212);" title="Subscribe to TWiM" href="http://twim

The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts. <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<span class="Apple-style-span" style="

Hosts: Vincent Racaniello and Michael Schmidt. Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron. Subscribe to TWiM (free) on iTunes, via RSS feed, by email or lis

  Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.

The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis.   Links for this episode:   <ul style="margin-to

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<span class="Apple-style-span" style="

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<s

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<span class="Apple-style-span" style="

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<s

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Jo Handelsman.<span class="Apple-s

Hosts: Vincent Racaniello Guests: Maria Julia Marinissen, Edward H. You, and David R. Howell Vincent meets up with Maria, Edward, and David at the ASM Biodefense and Emerging Infections Research meeting to talk about alternative careers for scientists. Subscribe to TWiM (free) on <a style="colo

  The TWiM crew ponders the question of how a bacterium finds its middle when dividing, then divulge the transfer of interbacterial antagonism genes to eukaryotes, where they may function in innate defense.   Links for this episode:</p

The TWiM team reveal how bacteria in a shipworm’s gills help digest wood in the gut, and an approach that identifies a new antibiotic from the soil.   Links for this episode:   <ul style="margin-top: 0pt; margin-bottom: 0

Hosts: Vincent Racaniello. Special guest: Rob Knight Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants. Check out the Microbeworld app. Links for this episode Microbes en masse (Nature) Obesity alters gut microbial ecology (PNAS) Sharing microbiome with dogs (eLife) Earth microbi

Hosts: Vincent Racaniello. Special guest: Stanley Maloy Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science. Subscribe to TWiM (free) on iTunes, via RSS feed, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gc

Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.   Links for this episode:  

  Vincent, Elio, and Michael reveal that a soil-dwelling nematode can recognize and respond to a bacterial quorum sensing molecule through a sensory neuron.

Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.  

Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City. Visit microbeworld.org/twim for complete show notes. Thanks for listening!

  Vincent meets up with Laurene and David at the Annual Meeting of the Southern California Branch of the American Society for Microbiology, where they discuss how the Los Angeles County Department of Health is preparing for an outbreak of Ebola virus infection, and Cepheid’s game-changing, modular PCR system for the diagnosis of infectious diseases.

Vincent, Michele, and Michael discuss how a gene from bacteria protects a tick from plant cyanide poisoning, and enhanced transmission of Streptococcus pneumoniae by influenza virus co-infection in mice.

Michele speaks with members of the Department of Bacteriology at the University of Wisconsin - Madison, on the occasion of its designation as a Milestones in Microbiology site, where they discuss how the department has advanced the science and teaching of microbiology.  

Vincent, Elio, and Michael explore the fossilization of archaeal lipids, and highlight the recent ICAAC in Washington, D.C.  

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.<s

Vincent, Elio, Michael, and Michele discuss the diel transcriptional rythmns of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.

In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.

Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system.   

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson. <p style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-ima

Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling Salmonella by modulating host iron homeostasis. 

Hosts: Vincent Racaniello, Elio Schaechter, and Michele Swanson.  Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas. Links for this episode: Total synthesis of a yeast chromosome (Science) Evolution of Y. pestis to <a href="http://www.sciencedirect.com/science/a

Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.

Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn. 

Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.  

Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.  

Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.  

Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.

Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS. 

Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.  

Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.

Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological profiling to identify pathways targeted by antibiotics.

Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.

Vincent, Elio, Michael, and Michele discuss the amazingly high level of intergenera gene exchange among haloarchaea in an Antarctic lake, and the diversity of fungi on residential surfaces and the human forehead. 

Vincent, Elio, and Michael discuss how temperature triggers Neisseria menigitidis immune evasion, and protection of mice from ionizing radiation by feeding them black mushrooms.

Vincent, Elio, Michael, and Michele discuss the curious outer membrane vesicles of Neisseria meningitides, and sources of Clostridium difficile infection revealed by genome sequencing.

Hosts: Vincent Racaniello and Michelle Swanson. Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice. Links for this episode:  <ul style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; list-style-type: none; list-style-p

Vincent and Michael recorded this episode at the 53rd ICAAC in Denver, where they spoke with James Gern and James Johnson about rhinoviruses and extra-intestinal pathogenic E. coli.

Vincent, Michael, and Michelle discuss how a Staphylococcus aureus superantigen is critical for pathogenesis in a rabbit model, and the relationship of body odor to the axilla microbiome.

Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid 

Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.

Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.

Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.

Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.

Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates. 

Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria. This episode was filmed live at ASM GM 2013 in Denver, CO. Visit www.microbeworld.org/asmlive to watch the full video archive of this episode as well as all the videos recorded during GM. 

Vincent, Elio and Michael discuss the finding that copper surfaces reduce microbial burden and hospital-acquired infections in the intensive care unit.

Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.

Vincent, Laura, David, Kalin and Paul get together at the Society for General Microbiology meeting in Manchester, England to talk about next-generation approaches to antimicrobial therapy.

Vincent and Michael meet up with Ellen Jo Baron to talk about working in a clinical microbiology laboratory.

Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.

Vincent, Michael, and Stanley review the scientific career of Carl Woese.

Vincent, Michael, and Elio discuss the HIV co-receptor CCR5 as a receptor for S. aureus leukotoxin ED, and the vineyard

Vincent, Michael, and Jo discuss how subtle gender bias of science faculty favors male students, and the relationship of invasive infection and antibody orientation at bacterial surfaces.

Horizontal transfer of antibiotic resistance genes on metal surfaces, and using bacteriophage to reverse antibiotic resistance.

Vincent, Michael, and Elio meet up with Jonathan Dworkin to discuss how bacteria form spores and how they return to vegetative growth.

Vincent, Michael, Elio review innate immune sensing of Listeria secreted bacterial nucleic acids, and how Wolbachia enhances egg production in Drosophila.

Vincent, Michael, Elio discuss the role of prophage excision in exit of Listeria from the phagosome, and analysis of bacterial communities in saliva.

Vincent, Michael, Elio review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.

Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.

Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.

**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!** Vincent and Stanley meet with Waclaw Szybalski an

Vincent, Michael, and Elio reviews chapters from Microbes and Evolution, a collection of short, personal essays by mic

Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.

Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.

Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.

Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas. Right click to download T

Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut. <span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style:

Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus. 

Hosts: Vincent Racaniello, Jo Handelsman, and Michael Schmidt <span id="internal-source-marker_0.7109660827554

On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.

On episode #29 of the podcast, Vincent and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.

Vincent, Michael, and Elio review how competition within a host drives virulence of Streptococcus pneumoniae, and the expanding universe of the bacterial cytoskeleton.

Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.

Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria. 

On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.

Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.

Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.

Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.

Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.

On episode #20 of the podcast This Week in Microbiology, Vincent, Michael, and Elio follow up on the outbreaks of E. coli in Germany and cholera in Haiti

Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.

Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.

Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.

On episode #16 of the podcast This Week in Microbiology, Vincent, Michael, <a href="http://www.einstein.yu.edu/home/faculty/profile.asp?id

On episode #15 of the podcast This Week in Microbiology, Vincent, Michael and Jo review the number of species on Earth, evidence that the 2010 Haitian cholera outbreak originated in Nepal, and how gut microbiota influence the immune response to influenza virus infection of the lung. <a href="http://mbio.asm.org/content/2/4/e00157-11/F2.large.jpg" mce_href="http://mbio.asm.org/content/2/4/e00157-11/F2.large.jpg"

On episode #14 of the podcast This Week in Microbiology, Stanley, Margaret, Michael and Elio review how the fungus Cryptococcus<span class="Apple-style-span" style="font-family: Times; font-

On episode #13 of the podcast This Week in Microbiology, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a probiotic-derived soluble protein to the colon.

Vincent, Margaret, Michael and Elio review the use of photothermal nanoblades to dissect the Burkholderia intracellular life cycle, and manipulation of chromosomes <span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: itali

Vincent, Margaret, Michael and Elio review the presence of extended spectrum beta-lactamase genes in chicken meat and in humans, and a beneficial effect of Helicobacter pylori colonization on the development of allergen-induced asthma.

On episode #10 of the podcast This Week in Microbiology, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri.

Vincent, Michael, and Cliff review the outbreak of bloody diarrhea and hemolytic uremic syndrome in Germany caused by Shiga toxin-producing <span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; text-decoration: no

Vincent, Michael, and Stanley recorded TWiM #8 live at the 2011 ASM General Meeting in New Orleans, with guests Andreas Baümler, Nicole Dubilier, and Paul Rainey. They spoke about how pathogens benefit from disease, symbioses between chemosynthetic bacteria and marine invertebrates, and repetitive sequ

Vincent, Cliff, Elio, Margaret, and Michael discuss programmed cell death in E. coli, and the daily synthesis and degradation of enzymes needed for photosynthesis and nitrogen fixation by cyanobacteria.

Vincent, Cliff, Michael and Elio review the use of bacteriophages to manage infections, and the presence of antibiotic resistance genes in the bacteriophage from urban sewage and river water.

Vincent, Ron, Cliff, and Michael discuss the genome sequence of a mercury-methylating bacterium and the antimicrobial effects of nanoparticles.

Vincent, Cliff, Margaret, and Michael review foodborne bacterial illness in the context of outbreaks associated with cantaloupes and Lebanon bologna.

Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.

Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.

On episode #1 of the podcast This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.