Ulcerative colitis can significantly decrease quality of life. A third of patients have persistent symptoms with tumor necrosis factor inhibitors and nearly 1 in 5 patients will be hospitalized within 5 years of diagnosis. Author Gilaad G. Kaplan, MD, MPH, of the University of Calgary joins JAMA Associate Editor John M. Inadomi, MD, to discuss Risankizumab for Ulcerative Colitis. Related Content: Monoclonal Antibody Risankizumab for Ulcerative Colitis Risankizumab for Ulcerative Colitis

What are the ovarian cancer risks associated with endometriosis subtypes? Author Karen C. Schliep, PhD, MSPH, of the University of Utah joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Endometriosis Typology and Ovarian Cancer Risk. Related Content: Endometriosis Typology and Ovarian Cancer Risk New Insights in Endometriosis Subtypes and Ovarian Cancer Risk

Oral nicotine pouches are becoming more popular in the US, based on a survey performed in 2022. Hongying Daisy Dai, PhD, from Nebraska Medical Center, Omaha, discusses nicotine pouches and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Prevalence of Nicotine Pouch Use Among US Adults

Availability of pediatric care is decreasing, despite the growing complexity of pediatric care needs. Match rates for pediatric residency continue to decline. The US risks a serious shortage of pediatricians. Julie Byerley, MD, MPH, executive vice president & chief academic officer, Geisinger, Pennsylvania, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Where Are All the Pediatricians?

Facilitating safe and timely health care for individuals planning medication abortion is a reproductive health care priority. Lauren J. Ralph, PhD, MPH, and Daniel Grossman, MD, of University of California San Francisco join JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Comparison of Effectiveness of No-Test Telehealth and In-Person Medication Abortion. Related Content: Comparison of No-Test Telehealth and In-Person Medication Abortion

Can a new ECG finding identify individuals at risk for dying suddenly? Jason D. Roberts, MD, of McMaster University joins JAMA Associate Editor Gregory M. Marcus, MD, MAS, to discuss A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome (CRDS). CRDS is a recently described cause of sudden arrhythmic death. Until now, no clinical test has existed to identify those with the disease. Related Content: A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome The First Clinical Test for Calcium Release Deficiency Syndrome?

Joel M. Dulhunty, MD, PhD, Royal Brisbane and Women’s Hospital, and Jason A. Roberts, BPharm, PhD, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock. Related Content: Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock

Randomized clinical trials (RCTs) frequently fail to generate knowledge relevant to practice, while practice patterns are frequently unsupported by RCT evidence. Derek C. Angus, MD, MPH, of the University of Pittsburgh, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided. Related Content: The Integration of Clinical Trials With the Practice of Medicine

Forced nitrogen inhalation was used by the state of Alabama to execute Kenneth Smith on January 25, 2024. Some politicians, attorneys general, and health care practitioners support its use for capital punishment in the US. Philip E. Bickler, MD, PhD, and Michael S. Lipnick, MD, discuss the evidence indicating that forced nitrogen inhalation is inhumane with JAMA Executive Editor Gregory Curfman, MD. Related Content: Evidence Against Use of Nitrogen for the Death Penalty

Guidelines call for better evidence on the health outcomes after living kidney donation. Author Amit X. Garg, MD, PhD, London Health Sciences Centre, and editorialist Elizabeth C. Lorenz, MD, Baylor College of Medicine, discuss a new study that compares the risks of hypertension and other health outcomes in living kidney donors, with JAMA Associate Editor Wolfgang Winkelmayer, MD, ScD. Related Content: Hypertension and Kidney Function After Living Kidney Donation Prospectively Examining Outcomes After Living Kidney Donation Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis Expanding the Overton Window in Deceased Kidney Donor Eligibility—Enough to Make a Difference?

What is the natural history and cardiovascular burden of the V142I transthyretin variant among US Black individuals who carry this variant? Senthil Selvaraj, MD, MS, MA, from Duke University, and Scott D. Solomon, MD, from Brigham and Women’s Hospital, discuss this and more with JAMA Executive Editor Gregory Curfman, MD. Related Content: Cardiovascular Burden of the V142I Transthyretin Variant Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger Heart Failure in African American Individuals, Version 2.0 Cardiac Amyloidosis Due to Transthyretin Protein

Between 2019 and 2021, pediatric mortality rates had the largest increases in at least half a century. Steven H. Woolf, MD, MPH, of Virginia Commonwealth University Center on Society and Health, joins JAMA Associate Editor Tracy A. Lieu, MD, MPH, to discuss how racial and ethnic disparities and specific causes have factored into these increases and what this means for policymakers and clinicians. Related Content: Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth Injury Prevention Science and Firearm Injury in Pediatric Health

When initial treatment with varenicline or nicotine replacement doesn't work, does increasing dosage improve smoking cessation rates? Paul Cinciripini, PhD, of MD Anderson Cancer Center's Department of Behavioral Science, joins JAMA Executive Editor Gregory Curfman, MD, to discuss guidance on the best strategies for smoking cessation following an initial quit attempt. Related Content: Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement

Extensive evidence documents health disparities for lesbian, gay, and bisexual (LGB) women, including worse physical, mental, and behavioral health than heterosexual women. Sarah McKetta, ScM, MD, PhD, discusses these factors and their link to premature mortality with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses

Can real-time EHR–generated recommendations safely reduce antibiotic use in hospitalized patients with pneumonia or UTI? Shruti K. Gohil, MD, MPH, of the University of California-Irvine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the INSPIRE randomized clinical trial. Related Content: Stewardship Prompts to Improve Antibiotic Selection for Pneumonia Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing

Climate action is an urgent public health imperative. Climate change is causing excess morbidity and mortality and posing an increasing threat to mental health and well-being. The US health care sector is a significant contributor to this problem. A. Eugene Washington, MD, of Duke University, discusses accelerating climate action with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Accelerating Climate Action Through Academic Health Systems

The utility of prostate-specific antigen (PSA) screening for prostate cancer detection is impacted by detection of cancers with low risk of mortality. Editorialist Jeffrey J. Tosoian, MD, MPH, discusses a pragmatic approach to prostate cancer screening with JAMA Deputy Editor Mary L. (Nora) Disis, MD. Related Content: A Pragmatic Approach to Prostate Cancer Screening Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality

Infections due to multidrug-resistant organisms (MDROs) are difficult to treat with increased morbidity, mortality, length of hospitalization, and health care costs. Author Susan S. Huang, MD, MPH, from the University of California Irvine School of Medicine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss a new study that used a regional intervention to prevent MDROs. Related Content: Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes

The US Supreme Court will soon decide a case challenging the US Food and Drug Administration’s (FDA’s) approval of mifepristone. Author Holly Fernandez Lynch, JD, MBE, University of Pennsylvania, joins JAMA Executive Editor Gregory Curfman, MD, to discuss the science and politics surrounding this significant case. Related Content: The FDA in the Crosshairs—Science, Politics, and Abortion Provision of Medications for Self-Managed Abortion Before and After the Dobbs v Jackson Women’s Health Organization Decision Understanding the Impacts of the Supreme Court Case FDA v Alliance for Hippocratic Medicine

How did GPT-4 Vision, a model that can work with images and text as input, perform when answering clinical challenge questions from medical journals? Daniel Truhn, MD, MSc, of the University Hospital Aachen in Germany, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss this topic. Related Content: Comparative Analysis of Multimodal Large Language Model Performance on Clinical Vignette Questions

An observational study by Lin Li, PhD, and colleagues, published in JAMA, found that pharmacotherapy was associated with reduced mortality in individuals with ADHD. Frances R. Levin, MD, of the Columbia Vagelos College of Physicians and Surgeons, who wrote an accompanying editorial, joins JAMA Associate Editor Donald C. Goff, MD, to discuss the results of this article. Related Content: Treating Attention-Deficit/Hyperactivity Disorder Matters

Introducing JAMA's new Communicating Medicine series, JAMA Associate Editor Anne Cappola, MD, ScM, discusses strategies for delivering effective messages in the patient encounter with authors Joseph Cappella, PhD, of the University of Pennsylvania, and Richard Street, PhD, of Texas A&M University and Baylor College of Medicine. Related Content: Delivering Effective Messages in the Patient-Clinician Encounter

How will new study results inform HIV prevention in the US and globally? JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Jeanne Marrazzo, MD, MPH, director of NIAID, discuss these study findings and more. Related Content: HIV Preexposure Prophylaxis With Emtricitabine and Tenofovir Disoproxil Fumarate Among Cisgender Women

JAMA Associate Editor Romain Pirracchio, MD, MPH, discusses context and implications of the new pediatric sepsis criteria with authors Hallie Prescott, MD, MSc, of the University of Michigan and Ann Arbor VA Hospital, and Roberto Jabornisky, MD, of Northeastern National Medical School in Argentina. Related Content: Context and Implications of the New Pediatric Sepsis Criteria Transitioning From SIRS to Phoenix With the Updated Pediatric Sepsis Criteria—The Difficult Task of Simplifying the Complex

Renters who received eviction filings experienced excess mortality associated with the COVID-19 pandemic. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, discusses a recent study that underscores the importance of studying health outcomes among marginalized populations with author Nick Graetz, PhD, from Princeton University. Related Content: Examining Excess Mortality Associated With the COVID-19 Pandemic for Renters Threatened With Eviction

Childhood death rates remain high in some areas of sub-Saharan Africa, despite global reductions in childhood mortality. JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Thomas Lietman, MD, University of California, San Francisco, discuss twice-yearly azithromycin to reduce childhood mortality. Related Content: Mass Azithromycin Distribution to Prevent Child Mortality in Burkina Faso

Bivalent mRNA COVID-19 vaccines were recommended for children and adolescents aged 5 to 17 years in the US, but were they effective? JAMA Associate Editor Tracy A. Lieu, MD, MPH, spoke with author Leora R. Feldstein, PhD, US Centers for Disease Control and Prevention, about the effectiveness of bivalent COVID-19 vaccines in children and adolescents. Related Content: Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years

Following the Dobbs decision, females aged 18-45 years living in states with “trigger laws” that restricted access to abortion reported a greater increase in symptoms of anxiety and depression than those in states without trigger laws. JAMA Associate Editor Donald Goff, MD, speaks with editorialist Julia Steinberg, PhD, associate professor at the School of Public Health at the University of Maryland, about this topic. Related Content: Mental Health Symptoms When Abortion Access Is Restricted Anxiety and Depression Symptoms After the Dobbs Abortion Decision

JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Alexander K. Smith, MD, MS, MPH, University of California, San Francisco, discuss the importance of 2 new palliative care trials that were recently published in JAMA. Related Content: A Tale of 2 Palliative Care Trials Association of Receipt of Palliative Care Interventions With Health Care Use, Quality of Life, and Symptom Burden Among Adults With Chronic Noncancer Illness

Dialysis facilities in the US are financially rewarded for higher rates of home dialysis and kidney transplant, but facilities that serve patients with high social risk might have a harder time meeting these goals. JAMA Associate Editor Karen E. Joynt Maddox, MD, MPH, speaks with Amal N. Trivedi, MD, MPH, of Brown University, about how this plays out under the ESRD Treatment Choices Model. Related Content: Social Risk and Dialysis Facility Performance in the First Year of the ESRD Treatment Choices Model

Alpha-gal syndrome is a food allergy to red meat products that develops after affected individuals are bitten by a tick. JAMA Deputy Editor Kristin Walter, MD, MS, discusses alpha-gal syndrome with author Mariel R. Benjamin, MD, assistant professor in the Division of Allergy and Clinical Immunology at Michigan Medicine. Related Content: What Is Alpha-Gal Syndrome?

The effects of private equity acquisition of US hospitals on the quality of inpatient care and patient outcomes remain largely unknown. JAMA Associate Editor Karen E. Joynt Maddox, MD, MPH, spoke with author Zirui Song, MD, PHD, of Boston General Hospital, about a recent study showing that private equity acquisition was associated with increased hospital-acquired adverse events. Related Content: Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition

Does reducing dietary sodium benefit patients already taking antihypertensive medication? JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, speaks with author Norrina Allen, PhD, MPH, from Northwestern University, about the effect of dietary sodium on blood pressure. Related Content: Effect of Dietary Sodium on Blood Pressure

Cannabis use is increasing among reproductive-age individuals. JAMA Deputy Editor Linda Brubaker, MD, MS, discusses the associated risks of cannabis exposure during pregnancy with Torri D. Metz, MD, MS, University of Utah Health. Related Content: Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function

Bilateral renal agenesis results in lethal neonatal pulmonary hypoplasia. New evidence from an amnioinfusion trial is available. JAMA Deputy Editor Linda Brubaker, MD, MS, discusses the results from the Renal Anhydramnios Fetal Therapy Trial with Meredith A. Atkinson, MD, MHS, Johns Hopkins University, and Johnathan M. Davis, MD, Tufts University. Related Content: Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis

Cervical cancer screening is effective when done as recommended. JAMA Deputy Editor Linda Brubaker, MD, speaks with Rachel L. Winer, PhD, MPH, of the University of Washington, about a recent trial in JAMA that compared cervical cancer screening strategies, including direct-mail and opt-in approaches for human papillomavirus (HPV) self-sampling. Related Content: Strategies to Increase Cervical Cancer Screening With Mailed Human Papillomavirus Self-Sampling Kits

Small-volume blood collection tubes may decrease red blood cell transfusions in intensive care units without affecting laboratory analysis. JAMA Associate Editor Christopher W. Seymour, MD, MSc, discusses the results and implications of the STRATUS trial with Deborah M. Siegal, MD, MSc, of Ottawa Hospital Research Institute. Related Content: Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care

Fitness trackers are a group of devices including watches, phones, and rings that track physical activity. JAMA Executive Editor Gregory Curfman, MD, speaks with I-Min Lee, MBBS, ScD, professor of medicine at Harvard Medical School and professor of epidemiology at Harvard T.H. Chan School of Public Health, about using fitness trackers to guide advice on activity prescription. Related Content: Fitness Trackers to Guide Advice on Activity Prescription

JAMA Senior Editor Kristin Walter, MD, MS, and Lawrence O. Gostin, JD, JAMA Legal and Global Health Correspondent and Faculty Director of the O’Neill Institute for National and Global Health Law at Georgetown University, discuss the Inflation Reduction Act, which for the first time allows the Centers for Medicare & Medicaid Services to negotiate prescription drug prices with drug manufacturers. Related Content: Medicare’s Historic Prescription Drug Price Negotiations

JAMA Executive Editor Gregory Curfman, MD, speaks with Richard G. Bach, MD, professor of medicine and medical director of the cardiac intensive care unit at the Washington University School of Medicine in St Louis, about the use of traditional Chinese medicine to treat patients with acute ST-segment elevation myocardial infarction. Related Content: Traditional Chinese Medicine Meets Evidence-Based Medicine in the Acutely Infarcted Heart

Optical coherence tomography (OCT) is a powerful imaging tool used across multiple clinical disciplines. JAMA Executive Editor Gregory Curfman, MD, speaks with 2023 Lasker Award recipient James G. Fujimoto, PhD, professor of electrical engineering at MIT, about his role in developing OCT and OCT’s advancements in clinical practice. Related Content: Optical Coherence Tomography—History, Evolution, and Future Prospects

Nasal mupirocin plus chlorhexidine baths in ICUs prevents methicillin-resistant Staphylococcus aureus (MRSA) infections but raises concern about antibiotic resistance. JAMA Senior Editor Kristin Walter, MD, speaks with Susan Huang, MD, of University of California, Irvine, about a study comparing iodophor vs mupirocin with chlorhexidine bathing for ICU-attributable S aureus clinical cultures. Related Content: Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs

It’s been unclear whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. JAMA Deputy Editor Chris Muth, MD, speaks with author Rolf Blauenfeldt, MD, Aarhus University Hospital, Denmark, about the RESIST randomized clinical trial, which looks at the effect of RIC when initiated in the prehospital setting. Related Content: Remote Ischemic Conditioning for Acute Stroke

During the COVID-19 pandemic, the incidence of diabetes in childhood increased. JAMA Associate Editor Anne R. Cappola, MD, ScM, and Ezio Bonifacio, PhD, from the Center for Regenerative Therapies at the Dresden University of Technology, discuss SARS-CoV-2 infection and its association with islet autoimmunity in early childhood. Related Content: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood

Many premature infants with respiratory distress are now supported with continuous positive airway pressure, or CPAP, rather than intubation and ventilation, and those with CPAP can receive surfactant via a minimally invasive approach. JAMA Associate Editor Tracy Lieu, MD, speaks with author Peter Dargaville, MD, from the Menzies Institute for Medical Research in Tasmania, Australia, about Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial. Related Content: Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants

There is an established link between sedentary behavior and cardiovascular disease, but the association between sedentary behavior and dementia is unclear. JAMA Deputy Editor Christopher C. Muth, MD, speaks with David A. Raichlen, PhD, University of Southern California, about a new study that investigates the relationship between sedentary behavior and dementia in older adults. Related Content: Sedentary Behavior and Incident Dementia Among Older Adults

In a new study, psilocybin showed promise as a treatment for major depressive disorder (MDD). JAMA Associate Editor Donald C. Goff, MD, speaks with author Charles L. Raison, MD, from the Usona Institute, about the study, as well as Rachel Yehuda, PhD, Mount Sinai School of Medicine, who wrote an accompanying editorial about the potential benefits of psychedelic therapies. Related Content: Single-Dose Psilocybin Treatment for Major Depressive Disorder Psychedelic Therapy—A New Paradigm of Care for Mental Health

Magnesium sulfate is widely recommended for neuroprotection in pregnancies at risk of preterm delivery. However, the optimal gestational age for use is unclear. JAMA Associate Editor Melissa Simon, MD, MPH, and Caroline Crowther, MD, Liggins Institute, University of Auckland, discuss the use of magnesium sulfate at different gestational ages and potential benefit vs harms as reflected in the MAGENTA Trial. Related Content: Prenatal Intravenous Magnesium at 30-34 Weeks’ Gestation and Neurodevelopmental Outcomes in Offspring

Anthracyclines are used to treat a variety of cancers, but treatment may be limited by cardiac toxicity. JAMA Executive Editor Gregory Curfman, MD, discusses a new clinical trial on the use of atorvastatin to prevent anthracycline-induced cardiac toxicity with authors Tomas Neilan, MD, MPH, and Marielle Scherrer-Crosbie, MD, PhD. Related Content: Atorvastatin for Anthracycline-Associated Cardiac Dysfunction

Cardiovascular health is essential to everyone, but especially important to address in individuals who can become or who are pregnant or postpartum. JAMA Associate Editor Melissa Simon, MD, MPH, and Sadiya S. Khan, MD, MSc, Northwestern University, discuss the importance of cardiovascular health in pregnancy-capable, pregnant, and postpartum persons, how to counsel such individuals, issues of access to care and health equity, and their impact on cardiovascular health. Related Content: Trends in Cardiovascular Health Counseling Among Postpartum Individuals

Bempedoic acid is an effective option for some statin-intolerant patients with an elevated predicted risk of cardiovascular events. However, as JAMA Executive Editor Gregory Curfman, MD, discusses with editorialist Dhruv S. Kazi, MD, MSc, MS, bempedoic acid should not be considered a substitute for statins, which remain the first-line therapy for primary prevention. Related Content: Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease

The performance of whole-genome sequencing in comparison with targeted genomic testing methods is not well understood. In this podcast, JAMA Associate Editor W. Gregory Feero, MD, PHD, interviews author Jill L. Maron, MD, MPH, of the Women and Infants Hospital of Rhode Island about a study of whole-genome sequencing vs a commercially available targeted genetic testing platform for diagnosing ill neonates with suspected genetic conditions. Related Content: Rapid Whole-Genomic Sequencing and a Targeted Neonatal Gene Panel in Infants With a Suspected Genetic Disorder

Valganciclovir is standard cytomegalovirus (CMV) prophylaxis in high-risk kidney transplant recipients, but its use is limited by myelosuppression. JAMA Deputy Editor Preeti Malani, MD, MSJ, interviews Ajit Limaye, MD, from the University of Washington, about a multinational randomized trial of letermovir vs valganciclovir for CMV prevention in CMV-negative patients receiving a kidney from a CMV-positive donor. Related Content: Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients

US hospitals report data on numerous quality metrics to government and independent rating organizations, but the cost of doing so is not well known. JAMA Associate Editor Karen E. Joynt Maddox, MD, discusses a new study that examines just how many quality metrics hospitals have to report, and attempts to quantify how much data collection and reporting costs in hours and dollars, with corresponding author Stephen A. Berry MD, PhD, Johns Hopkins University, Baltimore, Maryland. Related Content: The Volume and Cost of Quality Metric Reporting

Interview with Michael Silverstein, MD, MPH, USPSTF chair and coauthor of Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Anxiety Screening Depression and Suicide Risk Screening Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Are There Reasons to Fear Anxiety Screening? Reframing the Key Questions Regarding Screening for Suicide Risk

The US Black population experienced more than 80 million excess years of life lost compared with the White population over a recent 22-year period. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, discusses the research that quantified this disparity with authors César Caraballo, MD, Harlan M. Krumholz, MD, SM, and Clyde W. Yancy, MD, MSc. Related Content: Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020

Intentional miscoding of abortion services may put clinicians and hospital systems at legal risk. JAMA Senior Editor Linda Brubaker, MD, MS, and Carmel Shachar, JD, MPH, from the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard Law School, discuss the risks of intentional miscoding practices and possible penalties. Related Content: Abortion Miscoding—Legal Risks for Clinicians and Hospital Systems

The Covenant of Water, Stanford University professor Dr Abraham Verghese’s long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. In part 2, JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Verghese about the craft of writing fiction, the role of the humanities in medicine, of artificial intelligence in literature, and more. Related Content: “The Art of the Craft,” From The Covenant of Water The Covenant of Water – Reflections on Fiction, the Humanities, and Medicine (Part 1 of this interview)

The ACA’s preventive services mandate requires insurers to cover, without charge, nearly 200 basic primary care services. But now, a federal judge has issued a nationwide injunction preventing the Biden administration from enforcing this cost-free care for a significant number of these services. JAMA Executive Editor Gregory Curfman, MD, discusses this and more with Abbe R. Gluck, JD, Solomon Center for Health Law & Policy, Yale Law School. Related Content: Cost-Free Preventive Care Under the ACA Faces Legal Challenge

Most epidemiological studies of heart failure have been conducted in high-income countries. JAMA Senior Editor Kristin L. Walter, MD, MS, interviews Philip George Joseph, MD, from the Population Health Research Institute, Ontario, Canada, about a study of more than 23 000 patients with heart failure in 40 countries. Related Content: Global Variations in Heart Failure Etiology, Management, and Outcomes

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis Infection Among Non–US-Born Adults in the US Screening for Latent Tuberculosis Infection in Adults Screening for Latent Tuberculosis

The mental health of young people in the US has been an issue of increased concern in recent years. In this podcast, author Tanner Bommersbach, MD, MPH, assistant professor in the Department of Psychiatry and Psychology at the Mayo Clinic in Rochester, Minnesota, and Greg Rhee, PhD, a health services researcher and pharmacoepidemiologist at the University of Connecticut, join JAMA Senior Editor Kristin Walter, MD, MS, in a discussion about mental health-related emergency department visits in the US among children, adolescents, and young adults from 2011-2020. Related Content: National Trends in Mental Health–Related Emergency Department Visits Among Youth, 2011-2020

The Covenant of Water, Stanford University professor Dr Abraham Verghese’s long-awaited follow-up to his 2009 novel Cutting for Stone, traces the lives of a family in southern India negotiating forces of history, fate, and a genetic condition that takes the life of a member in each generation by drowning. JAMA Arts and Medicine Section Editor Michael Berkwits, MD, MSCE, talks with Dr Verghese about the novel’s clinical insights, the craft of writing fiction, the role of the humanities in medicine, of artificial intelligence in literature, and more. Related Content: “The Art of the Craft,” From The Covenant of Water

Major medical schools are no longer contributing data to the US News & World Report (USNWR) including more than half the schools that are currently ranked in the top 10 medical schools by the survey. In this podcast, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, speaks with author Holly J. Humphrey, MD, from the Josiah Macy Jr Foundation in New York, about the recently published Viewpoint "Medical School Rankings—Bad for the Health of the Profession and the Public." Related Content: Medical School Rankings—Bad for the Health of the Profession and the Public

Differences among countries in how health care is organized could have implications for health equity. JAMA Associate Editor Karen Joynt Maddox, MD, MPH, and Bruce E. Landon, MD, MBA, MSc, professor of health care policy, Harvard Medical School, discuss whether treatment patterns and outcomes for patients presenting with acute myocardial infarction differ for patients with higher vs lower incomes across 6 countries. Related Content: Differences in Treatment Patterns and Outcomes of Acute Myocardial Infarction for Low- and High-Income Patients in 6 Countries

JAMA Executive Editor Greg Curfman, MD, speaks with Robert D. Truog, MD, MA, director of the Harvard Center for Bioethics, who describes the 2 approaches to the determination of death (cardiovascular death and brain death) and discusses the possibility that the determination of brain death may soon undergo substantial change, with important implications for organ transplantation. Related Content: The Uncertain Future of the Determination of Brain Death

Mary Arakelyan, MPH, and JoAnna Leyenaar, MD, PhD, MPH, vice chair of Research in Pediatrics at Dartmouth, discuss increases in pediatric mental health hospitalizations and suicide-related diagnoses over the past decade. Hosted by JAMA Associate Editor Tracy Lieu, MD, MPH. Related Content: Pediatric Mental Health Hospitalizations at Acute Care Hospitals in the US, 2009-2019. Related Content: Pediatric Mental Health Hospitalizations at Acute Care Hospitals in the US, 2009-2019

In 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by early 2014. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Jayme E. Locke, MD, MPH, and Babak J. Orandi, MD, PhD, about their JAMA study describing results of the FDA announcement on subsequent rates of hospitalizations for acute liver failure due to toxicity from acetaminophen-containing opioid drugs. Related Content: Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity Acetaminophen (Paracetamol) and Acute Liver Failure

In this JAMA author interview, Peter J. Pronovost, MD, PhD, Chief Quality & Clinical Transformation Officer, University Hospitals, Cleveland, and an internationally recognized expert in patient safety, discusses his recent article in JAMA on “Misdiagnosis in the Emergency Department.” A new report from AHRQ underscores the seriousness of this problem. Related Content: Misdiagnosis in the Emergency Department

Interview with James Stevermer, MD, MSPH, USPSTF member and coauthor of Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement Reducing HSV-2 Morbidity and Mortality Reaffirmed USPSTF Recommendation Against Serologic Screening for Genital Herpes: Empowering Clinicians and Reducing Potential Harm Serologic Screening for Genital Herpes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Screening for Genital Herpes (Patient Page)

Susanna Naggie, MD, vice dean for research at Duke University's School of Medicine, discusses the ACTIV-6 trial of fluvoxamine for outpatient treatment of COVID-19 and outlines the role of platform trials during the pandemic. Hosted by JAMA Deputy Editor and Editorial Director for Equity Preeti Malani, MD, MSJ. Related Content: Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19

In the wake of new legal challenges to race-conscious admission policies, JAMA Interim Executive Editor Gregory Curfman, MD, discusses racial and ethnic diversity in undergraduate and medical school admission policies with Roy H. Hamilton, MD, MS, from the Perelman School of Medicine, University of Pennsylvania. Related Content: Defending Racial and Ethnic Diversity in Undergraduate and Medical School Admission Policies

JAMA Deputy Editor Preeti Malani, MD, MSJ, discusses potential next-generation COVID-19 vaccines with Peter Marks, MD, PhD, director of the Center for Biologics Evaluation and Research at the US Food and Drug Administration. Related Content: Urgent Need for Next-Generation COVID-19 Vaccines

In this JAMA author interview, we speak with Robert M. Califf, MD, Commissioner of the FDA, about a remarkable advance in the technology of hearing aids. Dr Califf has done important work to secure the entry of over-the-counter hearing aids into the market, providing a less expensive alternative to traditional hearing aids. In this interview, Dr Califf tells the story of how this technology has finally been made available to the public. Related Content: Over-the-counter Hearing Aids: From Research to Policy to Practice

Interview with Chris Zielinski, Visiting Research Fellow and Faculty of Health and Wellbeing at the University of Winchester, UK, James Kigera, Editor-in-Chief, Annals of African Surgery, and James Tumwine, Editor-in-Chief, African Health Sciences, authors of COP27 Climate Change Conference—Urgent Action Needed for Africa and the World. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD. Related Content: COP27 Climate Change Conference—Urgent Action Needed for Africa and the World Conflict and Climate Collide to Create an Acute Hunger Crisis for an Unprecedented 345 Million People Climate Justice and Health Children, Climate Justice, and Lessons From Puerto Rico

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea USPSTF Updates Recommendation for Obstructive Sleep Apnea Screening in Adults

Interview with Carol Mangione, MD, MSPH, USPSTF chair and coauthor of Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Menopausal Hormone Therapy for Prevention of Chronic Conditions

Interview with Martha Kubik, PhD, RN, USPSTF member and coauthor of Screening for Anxiety in Children and Adolescents: US Preventive Services Task Force Recommendation Statement, and Screening for Depression and Suicide Risk in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Anxiety in Children and Adolescents Screening for Anxiety in Children and Adolescents Screening for Depression and Suicide Risk in Children and Adolescents Screening for Depression and Suicide Risk in Children and Adolescents Screening for Anxiety in Children and Adolescents Screening for Pediatric Anxiety Disorders

In this JAMA Author Interview, JAMA Interim Executive Editor Greg Curfman, MD, speaks with Mary M. McDermott, MD, professor of medicine at Northwestern University Feinberg School of Medicine, on current therapies for peripheral artery disease and a new clinical trial she directed on the use of telmisartan, an angiotensin receptor blocker, for patients with peripheral artery disease. Related Content: Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Screening for Syphilis Infection in Nonpregnant Adolescents and Adults: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: The Critical Need to Modernize Syphilis Screening Screening for Syphilis Infection in Nonpregnant Adolescents and Adults Screening for Syphilis Infection in Nonpregnant Adults and Adolescents Screening for Syphilis

JAMA Network Open Editor Frederick Rivara, MD, MPH, discusses approaches to reducing firearm violence with several JAMA Viewpoint authors: Sandro Galea, MD, DrPH (Boston University), Elinore J. Kaufman, MD, MSHP (University of Pennsylvania), and Roger A. Mitchell Jr, MD (Howard University). Topics include the state-level response to firearm-related harms, the paucity of data on firearm violence, and the pervasive health effects of firearm violence on neighborhoods and in the carceral system. Related Content: The Epidemiology of Firearm Injuries in the US: The Need for Comprehensive, Real-time, Actionable Data Violence and the Carceral State: A Public Health Continuum State Firearm Laws and Firearm-Related Mortality and Morbidity Examining the Impact of Firearm Safety Laws on Suicides Physicians and EMS Who Responded to Mass Shootings Develop Consensus Recommendations for Improving Care Approaches to Reducing Firearm Violence

CRISPR genome editing is a revolutionary technology that can be used to make highly targeted changes in DNA in living cells. JAMA Associate Editor W. Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine Residency, and Matthew J. Kan, MD, PhD, University of California San Francisco, discuss how CRISPR works and how CRISPR-based technologies are being used in ongoing trials to treat a wide variety of medical conditions. Related Content: Treatment of Genetic Diseases With CRISPR Genome Editing With First CRISPR Trials, Gene Editing Moves Toward the Clinic

Arguably, a clinician’s most important role is providing an accurate and actionable diagnosis for patients. But challenges stand in the way, including tool limitations, inequitable access, and discontinuity of care. In this roundtable Q&A discussion, Urmimala Sarkar, MD, MPH (Zuckerberg San Francisco General Hospital and Trauma Center, UCSF), Jonathan H. Chen, MD, PhD (Stanford Center for Biomedical Informatics Research, Stanford University), and Harvey V. Fineberg, MD, PhD (Gordon and Betty Moore Foundation), discuss issues affecting diagnostic excellence, the emergence of artificial intelligence–driven tools, and ways to make the diagnostic process patient-focused. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, MD, PhD. Related Content: Decoding Artificial Intelligence to Achieve Diagnostic Excellence Diagnostic Excellence Achieving Diagnostic Equity in Cardiovascular Disease Achieving Diagnostic Excellence in the 21st Century Achieving Diagnostic Excellence

Interview with Michael D. Cabana, MD, MA, MPH, USPSTF member and coauthor of Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents Screening for Type 2 Diabetes in Children and Adolescents

Over a nearly 40-year career at the head of the National Institute of Allergy and Infectious Diseases, Anthony Fauci, MD, has seen a seismic shift in the way that science is communicated to and received by the public. In conversation with JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, Fauci reflects on his career at NIAID, the joys and challenges of advising 7 presidents, and shares his strategies for communicating scientific information in an ever-changing environment. Related Content: Dr Fauci and the Art of Science Communication Dr Anthony Fauci—Communicating Science in a Polarized Era

Interview with John B. Wong, MD, USPSTF member and coauthor of Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults Statin Use for the Primary Prevention of Cardiovascular Disease in Adults Statins for the Prevention of Cardiovascular Disease Statin Usage in Primary Prevention—Comparing the USPSTF Recommendations With the AHA/ACC/Multisociety Guidelines Statins for Primary Cardiovascular Disease Prevention Statins and Primary Atherosclerotic Cardiovascular Disease Prevention—What We Know, Where We Need to Go, and Why Are We Not There Already?

President Biden has signed into law the Inflation Reduction Act containing important provisions related to prescription drug costs. JAMA Health Forum Editor John Z. Ayanian, MD, MPP, and Deputy Editor Melinda B. Buntin, PhD, discuss the effects of these provisions on patients with Aaron S. Kesselheim, MD, JD, MPH, of Harvard Medical School and Brigham and Women’s Hospital. Related Content: New Reforms to Prescription Drug Pricing in the US Estimating Rebates and Other Discounts Received by Medicare Part D Estimation of the Share of Net Expenditures on Insulin Captured by US Manufacturers, Wholesalers, Pharmacy Benefit Managers, Pharmacies, and Health Plans From 2014 to 2018 Spending by the Centers for Medicare & Medicaid Services Before and After Confirmation of Benefit for Drugs Granted US Food and Drug Administration Accelerated Approval, 2012 to 2017 Improving Prescription Drug Affordability Through Regulatory Action

Electronic health records (EHRs) hold great promise to assist clinicians, but current versions are less user-friendly than ideal. JAMA Associate Editor Tracy Lieu, MD, MPH, spoke with Kevin B. Johnson, MD, MS, University of Pennsylvania, and William W. Stead, MD, Vanderbilt University Medical Center, about how to improve EHRs to protect cognitive attention and optimize their potential to provide cognitive support to health care professionals. Related Content: Making Electronic Health Records Both SAFER and SMARTER

In this Author Interview, JAMA Deputy Editor Gregory Curfman, MD, discusses the state of coronary artery bypass surgery in 2022 with E. Magnus Ohman, MD, from Duke University. The conversation emphasizes methods to preserve patency of saphenous vein bypass grafts, the subject of an article in the August 9, 2022, issue of JAMA. Dr Ohman wrote the accompanying Editorial. Related Content: Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery Balancing the Risks and Benefits of Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery

On August 3, 2022, the US Department of Health and Human Services released 2 major reports in response to a presidential memo calling for a whole-of-government response to the SARS-CoV-2 sequelae known as “Long COVID." JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, discusses these new reports and the research and support needed to address this pervasive health concern with HHS Assistant Secretary for Health Rachel Levine, MD. Recorded July 29, 2022. Related Content: Addressing the Long-term Effects of COVID-19 Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers Long COVID: The US Federal Response (Video)

Interview with Lori Pbert, PhD, USPSTF member and coauthor of Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Disease Risk Factors: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Senior Editor Kristin L. Walter, MD, MS. Related Content: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Disease Risk Factors Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity to Prevent CVD in Adults Without Risk Factors Implications of the New Recommendation on Behavioral Counseling Interventions to Promote Healthy Eating and Physical Activity Improving Behavioral Counseling for Primary Cardiovascular Disease Prevention Updated USPSTF Recommendations for Behavioral Counseling Interventions

Exercise limitation is a cardinal manifestation of heart failure with reduced ejection fraction (HFrEF), but it is not consistently improved by any of the current guideline-directed medical therapies. JAMA Deputy Editor Gregory Curfman, MD, discusses whether omecamtiv mecarbil can improve peak exercise capacity in patients with HFrEF with Gregory D. Lewis, MD, from Massachusetts General Hospital, and Mark H. Drazner, MD, MSc, from University of Texas Southwestern Medical Center. Related Content: Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial Omecamtiv Mecarbil as a Therapy for Heart Failure With Low Ejection Fraction

JAMA Associate Editor Preeti Malani, MD, MSJ, discusses the transmission, diagnosis, and treatment of monkeypox and the 2022 outbreak with Jeannette Guarner, MD, and Carlos del Rio, MD, both of the Division of Infectious Diseases at Emory University’s School of Medicine. Read Transcript Related Content: Monkeypox in 2022—What Clinicians Need to Know What Is Monkeypox? What to Know About Monkeypox Global Monkeypox Outbreaks Spur Drug Research for the Neglected Disease  

Patient safety is a national priority, but adverse events during hospitalization are hard to track and whether progress has been made over the past decade is unknown. JAMA Associate Editor Karen E. Joynt Maddox, MD, MPH, Washington University School of Medicine, discusses recent findings demonstrating decreases in hospital chart-abstracted adverse events and what’s next in patient safety in the wake of COVID-19, with Mark Metersky, MD, University of Connecticut Health Center, and Peter Pronovost, MD, PhD, University Hospitals, Shaker Heights, Ohio. Related Content: Trends in Adverse Event Rates in Hospitalized Patients, 2010-2019 Improvements in Hospital Adverse Event Rates: Achieving Statistically Significant and Clinically Meaningful Results

In July 2022, Kirsten Bibbins-Domingo, PhD, MD, MAS, took on a new role as the 17th editor in chief of JAMA and the JAMA Network. In conversation with Nobel laureate Harold Varmus, MD, Bibbins-Domingo discusses her research background, approaches to leadership in health care, and the critical role that journals play in communication about public health and science. Related Content: The Urgency of Now and the Responsibility to Do More—My Commitment for JAMA and the JAMA Network A Conversation With Dr Kirsten Bibbins-Domingo, JAMA’s New Editor in Chief (video) A Conversation With Dr Kirsten Bibbins-Domingo, JAMA’s New Editor in Chief (audio)

Observational data suggest that the risk of certain types of cancer may be increased in individuals with obesity and that this risk may be lower after bariatric surgery. JAMA Deputy Editor Gregory Curfman, MD, explores this in detail with Steven Nissen, MD, an author of a JAMA study on this topic, and Anita Courcoulas, MD, MPH, author of an accompanying editorial. Related Content: Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity Bariatric Surgery and Cancer Risk

Interview with John B Wong, MD, USPSTF member and coauthor of Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Mary M. McDermott, MD. Related Content: Multivitamins and Supplements—Benign Prevention or Potentially Harmful Distraction? Patient Information: Vitamins and Minerals to Prevent Cardiovascular Disease and Cancer

Interview with Lisa Rotenstein, MD, MBA, author of A Learning Health System Agenda for Organizational Approaches to Enhancing Occupational Well-being Among Clinicians, and Clyde W. Yancy, MD, author of Resident Physician Wellness Postpandemic: How Does Healing Occur?. Hosted by JAMA Associate Editor Anne Cappola, MD.

Interview with Katrina Erika Donahue, MD, MPH, coauthor of Screening for Primary Open-Angle Glaucoma: US Preventive Services Task Force Recommendation Statement, and Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Mary M. McDermott, MD. Related Content: USPSTF Review: Screening for Glaucoma in Adults USPSTF Review: Screening for Impaired Visual Acuity in Older Adults Patient Information: Screening for Primary Open-Angle Glaucoma Screening for Impaired Visual Acuity in Older Adults Patient Information: Screening for Impaired Visual Acuity in Older Adults Screening for Glaucoma

As the White House’s COVID-19 Response Coordinator, Ashish Jha, MD, MPH, plays a critical role in the federal government’s continued response to the pandemic. In this Q&A with JAMA Associate Editor Preeti Malani, MD, Jha details current thinking and federal planning around additional boosters, testing trends, and treatment for COVID-19. Related Content: New White House COVID-19 Leader on What’s Next Q&A With White House COVID-19 Response Coordinator Ashish Jha

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Senior Editor Kristin Walter, MD. Related Content: USPSTF Review: Screening for Chronic Obstructive Pulmonary Disease Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities USPSTF Recommendation: Screening for Chronic Obstructive Pulmonary Disease Patient Information: Screening for Chronic Obstructive Pulmonary Disease

After serving as commissioner of the US Food and Drug Administration (FDA) under President Obama, Robert M. Califf, MD, recently returned to the role, overseeing a critical federal agency that regulates food, drugs, therapeutics, and medical devices in the US. In a wide-ranging discussion with JAMA Deputy Editor Gregory Curfman, MD, Califf discusses COVID-19 vaccine modifications, the FDA’s approach to evaluating evidence, and efforts to combat health misinformation. Recorded April 26, 2022. Related Content: “Unfinished Business” Brings Robert Califf, MD, Back for a Second Stint as FDA Commissioner Q&A With FDA Commissioner Robert Califf

Interview with John B. Wong, MD, USPSTF member and coauthor of Aspirin Use for Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Deputy Editor Gregory Curfman, MD. Related Content: Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement Should Patients Take Aspirin for Primary Cardiovascular Prevention? USPSTF Review: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Updated Modeling Study for the US Preventive Services Task Force Patient Information: Use of Aspirin to Prevent Cardiovascular Disease Whom to Treat for Primary Prevention of Atherosclerotic Cardiovascular Disease

Misinformation about COVID-19 (such as around vaccines, masks, and ineffective drugs) has circulated widely during the pandemic, and much of this misinformation is protected by the Free Speech Clause of the First Amendment. Professor of Surgery and Perioperative Care and Professor of Law William M. Sage, MD, JD, from the University of Texas at Austin, is interviewed in this JAMA podcast. Related Content: Reducing “COVID-19 Misinformation” While Preserving Free Speech

Electrocardiographic markers of atrial myopathy are associated with dementia, but it is unclear whether 2-dimensional echocardiographic––defined LA function and size are associated with dementia. JAMA Senior Editor Philip Greenland, MD, discusses study findings with Wendy Wang, MPH, and Lin Yee Chen, MD, authors of Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia

As the largest public insurance program in the US, Medicare has an outsize influence in how many people in the US access and receive health care. Recently appointed Director of Center for Medicare Meena Seshamani, MD, PhD, joins JAMA Associate Editor Karen Joynt Maddox, MD, for a discussion of equitable, patient-centered approaches to health care delivery, and how her own experiences as a physician have illuminated how she leads the program. Related Content: Center for Medicare Director Envisions Holistic Approach to Health Care Leading Medicare: Q&A With Medicare Director Meena Seshamani Health System Factors Related to Overuse of Health Services in Medicare Leveraging Medicare to Advance Health Equity

Interview with Lori Pbert, PhD, USPSTF member and coauthor of Screening for Eating Disorders in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Atrial Fibrillation: US Preventive Services Task Force Recommendation Statement. Hosted by Gregory Curfman, MD.

Three members of President Biden’s former COVID-19 Advisory Board—Luciana Borio, MD, Ezekiel Emanuel, MD, PhD, and Mike Osterholm, PhD—discuss their recent JAMA Viewpoints, providing their ideas on strategies for public health as COVID-19 transitions from pandemic to endemic. Hosted by JAMA Associate Editor Preeti Malani, MD. Related Content: A National Strategy for the “New Normal” of Life With COVID A National Strategy for COVID-19—Testing, Surveillance, and Mitigation Strategies A National Strategy for COVID-19 Medical Countermeasures Former Biden-Harris Transition Advisors Propose a New National Strategy for COVID-19 Public Health in an Era of Endemic COVID-19 (video)

Former CDC Executive Secretariat of the Advisory Committee on Immunization Practices Amanda Cohn, MD, joins JAMA Associate Editor Preeti Malani, MD, for the latest on the need for vaccination and boosters, vaccine misinformation, and tackling the pandemic from a global perspective. Recorded January 6, 2022. Related Content: One Year of COVID-19 Vaccines: A Shot of Hope, a Dose of Reality COVID-19 Vaccines Have Been Available in the US for More Than a Year—What’s Been Learned and What’s Next? COVID-19 CDC Update – Early January 2022

Interview with Michael Cabana, MD, USPSTF member and coauthor of Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years: US Preventive Services Task Force Recommendation Statement. Related Content: Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years

Infectious disease experts Adam Lauring, MD, PhD, and Carlos del Rio, MD, join JAMA Associate Editor Preeti Malani, MD, MSJ, for a discussion of the newly emerged Omicron variant, the potential for a 2021-2022 "twindemic" with flu, and the latest COVID-19 clinical updates. Recorded December 1, 2021. Related content: Omicron Has Reached the US—Here’s What Infectious Disease Experts Know About the Variant COVID-19 Update: Omicron Variant

Phil Fontanarosa, MD, MBA, interim editor in chief of JAMA, interviews Harvey V. Fineberg, MD, PhD, from the Gordon and Betty Moore Foundation, and Abraham Verghese, MD, from Stanford University School of Medicine, about diagnostic excellence and a new series on this topic in JAMA. Related Content: Diagnostic Excellence Diagnosis and the Illness Experience: Ways of Knowing

Individuals who experience systemic, structural, institutional, and social barriers within society deserve better and more convenient health care access. This idea should be central when advancing efforts to achieve health equity. JAMA Editorial Board member Raina M. Merchant, MD, speaks with Courtney R. Lyles, PhD, and Urmimala Sarkar, MD, about approaches toward improving digital health equity and with Utibe R. Essien, MD, about enhancing targeted efforts toward realizing pharmacoequity. Related Content: A Policy Prescription for Reducing Health Disparities—Achieving Pharmacoequity Focusing on Digital Health Equity

Health care expenses that arise from largely nonclinical functions, such as coding and billing and administration, cost the US health care system almost $1 trillion annually. Michael Chernew, PhD, from Harvard Medical School Department of Health Care Policy, and David Cutler, PhD, from Harvard University Department of Economics, join JAMA Associate Editor Karen Joynt Maddox, MD, MPH, from Washington University School of Medicine to discuss some basic fixes and simplifications that could reduce administrative spending by an estimated $265 billion. Related Content: Waste in the US Health Care System: Estimated Costs and Potential for Savings Administrative Expenses in the US Health Care System: Why So High? Administrative Simplification and the Potential for Saving a Quarter-Trillion Dollars in Health Care Economic Incentives for Administrative Simplification Waste in the US Health Care System Waste in the US Health Care System

Interview with Jason A. Abbott, and Fiona G Li, authors of Effect of Fractional Carbon Dioxide Laser vs Sham Treatment on Symptom Severity in Women With Postmenopausal Vaginal Symptoms: A Randomized Clinical Trial

Death rattle, defined as noisy breathing caused by the presence of mucus in the respiratory tract, is common among dying patients. Harriette van Esch, MD, from the Erasmus Medical Center, the Netherlands, and Jared R. Lowe, MD, from the University of North Carolina, join JAMA Associate Editor Ethan Basch, MD, to discuss evidence about use of prophylactic scopolamine butylbromide to reduce the death rattle. Related Content: Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle Preventing Death Rattle With Prophylactic Subcutaneous Scopolamine Butylbromide

Canadian law gives the country’s individual provinces and territories primary responsibility for coronavirus containment and mitigation. JAMA Associate Editor Preeti Malani, MD, MSJ, from the University of Michigan and Allan S. Detsky, MD, PhD, from the University of Toronto, Ontario, Canada, discuss the national pandemic experience, including public health responses to infection and vaccine allocation, from fall 2020 through summer 2021. Related Content: COVID-19 in Canada: Experience and Response to Waves 2 and 3

Interview with Aaron B. Caughey, MD, USPSTF member and coauthor of Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Related Content: Low-Dose Aspirin for the Prevention of Preeclampsia USPSTF Recommendation: Aspirin Use to Prevent Preeclampsia Patient Information: Use of Aspirin During Pregnancy to Prevent Preeclampsia

Interview with Martha Kubik, PhD, RN, USPSTF member and coauthor of Screening for Chlamydia and Gonorrhea: US Preventive Services Task Force Recommendation Statement

While health disparities have gained growing attention in recent years, much work is still needed, as inequities continue to have a direct and measurable negative influence on patients in historically disadvantaged communities. David Satcher, MD, PhD, Francisco Cigarroa, MD, and Howard Koh, MD, MPH, join moderator Ebony Boulware, MD, MPH, to discuss the vital importance of the visibility of all races and ethnicities in research, medical schools, and health care. They propose potential solutions, including the recruitment of and support for more physicians who look like their patients, who care enough, know enough, have the courage to make a difference, and who will persevere until changes are made. Related Content: Healing and Health Equity for Asian American, Native Hawaiian, and Pacific Islander Populations Uplifting the Latino Population From Obscurity to the Forefront of Health Care Does Race Interfere With the Doctor-Patient Relationship? (published 1973) Race and the Patient-Physician Relationship in 2021

Noninvasive ventilation (NIV) may help COVID-19 patients in respiratory failure avoid invasive mechanical ventilation but may also lead to delays in intubation with potential for worse clinical outcomes. Domenico L. Grieco, MD, of Fondazione Policlinico Agostino Gemelli IRCCS in Rome, Jesse B. Hall, MD, of the University of Chicago, and Laveena Munshi, MD, MSc, of Sinai Health System/University Health Network of the University of Toronto join JAMA's live Q&A series to discuss helmet NIV, high-flow nasal oxygen, and other NIV modalities in the management of hypoxic coronavirus patients. Recorded March 25, 2021. Related Content: Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet? Noninvasive Ventilation of COVID-19 Patients

Interview with Kimberly Maxfield, PhD, author of Precision Dosing—A Clinical and Public Health Imperative

Interview with Chien-Wen W. Tseng, MD, USPSTF member and coauthor of USPSTF Recommendation: Screening for Hearing Loss in Older Adults

Coronavirus trends, variants, vaccines, treatment, and more. JAMA Associate Editor Preeti Malani, MD, MSJ, also from the University of Michigan, and Emory University School of Medicine's Carlos del Rio, MD, return to JAMA's Q&A series to discuss the latest in COVID-19 medicine and public health. Recorded March 15, 2021. Related Content: COVID-19 in 2021—Continuing Uncertainty Coronavirus Update With Carlos del Rio and Preeti Malani Frequently Asked COVID Vaccine Questions

Lisa A. Cooper, MD, MPH, of Johns Hopkins University School of Medicine; Clyde W. Yancy, MD, MSc, of Northwestern University, and David R. Williams, PhD, MPH, of Harvard T.H. Chan School of Public Health, join JAMA Editor in Chief Howard Bauchner, MD, to discuss racism and structural racism in health care and medicine. Recorded March 16, 2021.

Interview with Thomas R. Frieden, MD, MPH, author of National Initiatives to Prevent Myocardial Infarction and Stroke

Interview with Michael J. Barry, MD, author of USPSTF Recommendation—Screening for Lung Cancer

Genetic variants of the SARS-CoV-2 virus are emerging but so far do not seem to have caused breakthrough infections in people with previous infection or in those who have been vaccinated. John P. Moore, PhD, of Weill Medical College of Cornell University in New York, joins JAMA's Q&A series for an update on the latest variants and what you need to know. Recorded March 4, 2021. Related Article: Approaches for Optimal Use of Different COVID-19 Vaccines

Interview with Christopher J.L. Murray, MD, DPhil, author of The Potential Future of the COVID-19 Pandemic: Will SARS-CoV-2 Become a Recurrent Seasonal Infection?

Nancy E. Messonnier, MD is director of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention (CDC) and leads the CDC’s efforts on COVID-19 vaccination. She joins JAMA's Q&A series to discuss the agency's response to emerging coronavirus variants, the FDA advisory hearings on the new Johnson & Johnson vaccine, and other agency activities and priorities related to COVID-19 control. Recorded February 26, 2021. Related Content: Genetic Variants of SARS-CoV-2—What Do They Mean? Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants Experts Discuss COVID-19—Vaccine Doses, Virus Variants, and More Emergence of a Novel SARS-CoV-2 Variant in Southern California SARS-CoV-2 Variants of Concern in the United States Pregnant People Getting Mixed Messages About COVID-19 Vaccines The Johnson & Johnson Vaccine for COVID-19 SARS-CoV-2 Viral Variants—Tackling a Moving Target Vaccine Distribution—Equity Left Behind? Taking Vaccine to Where the Virus Is—Equity and Effectiveness in Coronavirus Vaccinations?

Interview with James C. Robinson, PhD, author of Funding of Pharmaceutical Innovation During and After the COVID-19 Pandemic

Interview with Richard Saitz, MD, author of Removing One Barrier to Opioid Use Disorder Treatment: Is It Enough and with Yngvild Olsen, MD, author of Overcoming Barriers to Treatment of Opioid Use Disorder    

Interview with Ik-Kyung Jang, MD, PhD, author of New Insights Into Plaque Erosion as a Mechanism of Acute Coronary Syndromes

CDC Director Rochelle P. Walensky, MD, MPH, returns to JAMA's Q&A series to discuss the agency's response to emerging SARS-CoV-2 variants, implications for the planned vaccine mobilization strategy, the upcoming Johnson & Johnson vaccine FDA advisory hearings, strategies for reopening K-12 schools, and other agency activities and priorities related to COVID-19 control. Recorded February 17, 2021. Related Article(s): Coronavirus Update With CDC Director Rochelle Walensky - February 17, 2021 SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities SARS-CoV-2 Viral Variants—Tackling a Moving Target

Paul A. Offit, MD, of The Children's Hospital of Philadelphia returns to JAMA's Q&A series to provide an update on the emergence of COVID-19 variants and their implications for vaccine development, including the Johnson & Johnson vaccine, scheduled for a US Food and Drug Administration VRBPAC hearing on February 26, 2021. Recorded February 11, 2021. Related Article: SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants

As US vaccine distribution expands to include younger healthier populations, questions about vaccine safety in women of childbearing age have become more urgent. University of Texas Southwestern Medical Center's Catherine Y. Spong, MD, and Emory University School of Medicine's Denise J. Jamieson, MD, MPH, both eminent obstetrician/gynecologists, join JAMA's Q&A series to discuss the safety of the Pfizer-BioNTech and Moderna vaccines in pregnant and nursing mothers, and in individuals trying to get pregnant. Recorded February 8, 2021. Related Article(s): Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021 COVID-19 Vaccination in Pregnant and Lactating Women Involving Pregnant Individuals in Clinical Research on COVID-19 Vaccines

Interview with Lawrence O. Gostin, JD, author of Mandating COVID-19 Vaccines

Interview with Donald Berwick, MD, author of The Triple Aim Applied to Correctional Health Systems

2021 has brought news of emerging SARS-CoV-2 genetic variants that increase transmissibility. Will they diminish vaccine efficacy and lead us to lose pandemic control? University of Michigan's Adam Lauring, MD, PhD, a molecular virologist who uses evolutionary theory to study viral transmission and pathogenesis, joins JAMA's Q&A series to explain the variants and what they mean for public health. Recorded February 4, 2021. Related Article(s): Genetic Variants of SARS-CoV-2—What Do They Mean?

NIAID Director Anthony S. Fauci, MD, returns to JAMA's Q&A series to discuss Shifts in the US pandemic response under the Biden administration Emerging genetic variants and implications for vaccine efficacy Prospects for new vaccine approvals and more. Related Article: Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

Interview with Philip A. Pizzo, MD, author of When Physicians Engage in Practices That Threaten the Nation’s Health

Interview with Peter Pronovost, MD, PhD, author of Ensuring Quality in the Era of Virtual Care and Abraham Verghese, MD, author of Virtual Care and Real Connection in the Era of COVID-19

Interview with Michael J. Barry, MD, USPSTF member and coauthor of USPSTF Recommendation: Carotid Artery Stenosis

Peter Piot, MD, PhD, director of The London School of Hygiene and Tropical Medicine, is a legend in global health, having been involved in identification of HIV and Ebola virus in Africa. He was founding executive director of UNAIDS and Under Secretary-General of the United Nations from 1995 to 2008. He joins JAMA's Q&A series to discuss the global public health response to COVID-19 past, present, and future. Recorded January 28, 2021. Related Article(s): The Challenges Ahead With Monoclonal Antibodies

Interview with Frederick P. Rivara, MD, author of Three Interventions to Address the Other Pandemic—Firearm Injury and Death

Interview with John P A Ioannidis, MD, DSC, author of Recalibrating the Use of Race in Medical Research

President Biden has released a health care plan that proposes reducing the age of eligibility for Medicare to 60 years and introducing a public option. Larry Levitt, MPP, Executive Vice President for Health Policy at the Kaiser Family Foundation, JAMA Associate Editor Karen Joynt Maddox, MD, MPH, Co-Director of the Center for Health Economics and Policy (CHEP) at Washington University School of Medicine, and Lawrence O. Gostin, JD, from the O’Neill Institute for National and Global Health Law at Georgetown University discuss prospects for health care reform under the new administration. Recorded January 21, 2021. Related Article(s): Moving Patient Care Forward in the Biden Era

Incoming Centers for Disease Control and Prevention (CDC) Director Rochelle P. Walensky, MD, MPH, returns to JAMA's Q&A series to discuss her vision and priorities for the agency and changes in its pandemic response strategies, when she takes the reins on January 20. Recorded January 19, 2021. Related Article(s): All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020

To get more vaccine to more people more efficiently, UCSF School of Medicine's Robert M. Wachter, MD, recently urged giving a single dose now and deferring the second dose until more vaccine is available. Paul A. Offit, MD, of The Children's Hospital of Philadelphia, disagrees. The two discuss the pros and the cons of the plan and alternative responses to road bumps in the US vaccine rollout, on JAMA's live Q&A series. Recorded January 19, 2021. Related Article: Developing a SARS-CoV-2 Vaccine at Warp Speed

Intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) both improve outcomes for patients with acute ischemic stroke. Jeffrey L. Saver, MD, director of UCLA’s Comprehensive Stroke and Vascular Neurology Program and a JAMA Associate Editor, discusses 2 randomized trials comparing outcomes for stroke patients treated with IVT prior to EVT vs EVT alone. Related Article: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke

Interview with Raina M. Merchant, MD, author of Public Health Messaging in an Era of Social Media

Interview with Michael Silverstein, MD, MPH, USPSTF member and coauthor of USPSTF Recommendation: Tobacco Cessation in Adults

The COVID-19 pandemic has prompted scientists to use adaptive research designs to evaluate potential treatments simultaneously and efficiently, increasing the likelihood that patients will receive treatments most likely to be effective for them. Lennie Derde, MD, of University Medical Center Utrecht in the Netherlands and JAMA Associate Editor Christopher W. Seymour, MD, of University of Pittsburgh Medical Center join JAMA's Q&A series to discuss the latest in critical care management of COVID-19 patients and emerging treatment strategies and therapies. Recorded January 13, 2021. Related Article(s): Sensible Medicine-Optimizing the Trade-off Between Learning and Doing in a Pandemic

Arnold S. Monto, MD, chaired the US Food and Drug Administration's Vaccines and Related Biological Products Advisory Committee (VRBPAC) meetings in December that led to Emergency Use Authorization (EUA) of the Pfizer/BioNTech and Moderna vaccines. He joins JAMA's Q&A series from the University of Michigan School of Public Health to discuss experience to date with the 2 products and what's next in vaccine development. Recorded January 11, 2021. Related Article(s): Experts Discuss COVID-19: Vaccine Allocation, Placebo Groups, and More

Increasing the number of physicians who are Black, Hispanic/Latinx, and Indigenous benefits everyone in the US, but it cannot be the sole responsibility of historically Black colleges and universities (HBCUs). Valerie Montgomery Rice, MD, president and dean of Morehouse School of Medicine (MSM), and Clyde W. Yancy, MD, of Northwestern Medicine, join JAMA Editor in Chief Howard Bauchner, MD, to discuss options for developing training pipelines of underrepresented minority health science students, and how academic medicine can make racial justice a part of its work and mission. Recorded January 5, 2021. Related Article: Academic Medicine and Black Lives Matter

The National Academy of Medicine's 2000 report "To Err Is Human" launched the health care quality movement in the US. Victor Dzau, MD, president of the National Academy of Medicine, and Don Berwick, MD, MPP, from the Institute for Healthcare Improvement, discuss progress to date in advancing quality and prospects for improving outcomes and reducing harms, errors, and cost in the next 20 years. Recorded December 22, 2020. Related Article(s): Two Decades Since To Err Is Human

Interview with Geoffrey S. Ginsburg, MD, PhD, author of Digital Health—The Need to Assess Benefits, Risks, and Value

With coronavirus vaccines now available, what are the timeline and prospects for "herd immunity" and return to a new normal? Marc Lipsitch, DPhil, of Harvard T.H. Chan School of Public Health returns to JAMA's Q&A series with Paul D. Biddinger, MD, director of Massachusetts General Hospital's Center for Disaster Medicine, to discuss. Recorded December 17, 2020. Related Article(s): COVID-19 Vaccines and Herd Immunity The Ethics of Continuing Placebo in SARS-CoV-2 Vaccine Trials Evaluating SARS-CoV-2 Vaccines After Emergency Use Authorization or Licensing of Initial Candidate Vaccines Herd Immunity and Implications for SARS-CoV-2 Control Herd Immunity as a Coronavirus Pandemic Strategy

Peter W. Marks, MD, PhD, and Stephen M. Hahn, MD, return to JAMA's Q&A series to discuss the Pfizer/BioNTech and Moderna vaccines: the data, the weekend's EUA designation (Pfizer/BioNTech), and the process for future full licensure and postmarketing safety surveillance. Dr Marks directs the US FDA's Center for Biologics Evaluation and Research (CBER). Dr Hahn is commissioner of the US Food and Drug Administration. Recorded December 14, 2020. Related Article(s): Behaviorally Informed Strategies for a National COVID-19 Vaccine Promotion Program

Interview with David W. Baker, MD, MPH, author of Trust in Health Care in the Time of COVID-19

Interview with Chyke A. Doubeni, MD, MPH, USPSTF member and coauthor of USPSTF Recommendation: Screening for Hepatitis B Virus Infection in Adolescents and Adults

Anthony S. Fauci, MD, returns to JAMA's Q&A series to discuss the Pfizer/BioNTech and Moderna vaccines: the public data, deliberations at Thursday's FDA Advisory Committee meeting, and prospects for an agency Emergency Use Authorization designation, licensure, and rollout. Recorded December 11, 2020. Related Article(s): Coronavirus Infections—More Than Just the Common Cold

The COVID Tracking Project, launched by The Atlantic, collects and publishes data required to understand the COVID-19 outbreak in the US, including data on race and ethnicity needed to understand health inequities in the outbreak. Atlantic Monthly journalists Alexis C. Madrigal and Erin Kissane join JAMA's Q&A series to describe the project and their experience developing a database for fact-based health reporting on the pandemic. Recorded December 10, 2020.

The National Asthma Education and Prevention Program (NAEPP) of the NIH has updated its guideline recommendations for diagnosis and treatment of asthma patients. Michelle M. Cloutier, MD, from UConn Health, Stephanie Lovinsky-Desir, MD, of Columbia University Irving Medical Center, and JAMA Associate Editor George O'Connor, MD, MS, from Boston Medical Center join JAMA's Q&A series to discuss what's new, including revised advice about • Use of intermittent inhaled corticosteroids (ICSs) • Use of add-on long-acting muscarinic antagonists (LAMAs) • Use of fractional exhaled nitric oxide (FeNO) measurement as a diagnostic biomarker • Monitoring response to therapy • Indoor allergen mitigation strategies • Safety and efficacy of subcutaneous and sublingual immunotherapy • Use of bronchial thermoplasty Recorded December 8, 2020 Related Article(s): Managing Asthma in Adolescents and Adults

With the Pfizer and Moderna coronavirus vaccines reportedly under review at the US FDA for Emergency Use Authorization (EUA), Paul A. Offit, MD, of the Children's Hospital of Philadelphia, returns to JAMA's Q&A series to provide an update on what to expect, prospects for vaccine rollout and distribution in the coming months, and ongoing safety surveillance. Recorded December 2, 2020. Related Article: Developing a SARS-CoV-2 Vaccine at Warp Speed

Interview with Lawrence O. Gostin, JD, author of Health Policy in the Supreme Court and a New Conservative Majority

Yale Sterling Professor Nicholas A. Christakis, MD, PhD, MPH, returns to JAMA's Q&A series to discuss the surge in US cases and other recent pandemic developments. Dr Christakis is author of the recently published book "Apollo's Arrow: The Profound and Enduring Impact of Coronavirus on the Way We Live." Recorded November 23, 2020.  

Interview with Martha Y. Kubik, PhD, RN, USPSTF member and coauthor of Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors

In the midst of rising COVID-19 case rates globally, Derek C. Angus, MD, MPH, and Rochelle P. Walensky, MD, MPH, return to JAMA's Q&A series to update viewers on developments in the pandemic and the critical care management of COVID-19 patients. Dr Angus is Chief Health Care Innovation Officer at the University of Pittsburgh Medical Center, professor and chair of Critical Care Medicine, and a senior JAMA editor. Dr Walensky is Chief of Infectious Diseases at Massachusetts General Hospital and a professor at Harvard Medical School. Recorded November 19, 2020. Related Article(s): Optimizing the Trade-off Between Learning and Doing in a Pandemic

Interview with Ipsit V. Vahia, MD, author of Older Adults and the Mental Health Effects of COVID-19 Related Article(s): Older Adults and the Mental Health Effects of COVID-19

Interview with Eli Y. Adashi, MD, MS, author of Heritable Human Genome Editing: The International Commission Report

Ngozi O. Ezike, MD, director of the Illinois Department of Public Health, discusses state and regional management of the COVID-19 pandemic. Recorded November 9, 2020. Related Article(s): Universal Masking in the United States

Would letting coronavirus infect the broad US and global population be a safe and effective means of ending the COVID-19 pandemic? Jay Bhattacharya, MD, PhD, of Stanford University's Center for Primary Care and Outcomes Research is a signatory of the "Great Barrington Declaration," which proposes to "allow those at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk." Marc Lipsitch, PhD, of the Harvard T.H. Chan School of Public Health, a signatory of the "John Snow Memorandum," which refutes the argument, responds. Related Article: Herd Immunity and Implications for SARS-CoV-2 Control

Interview with Michael Silverstein, MD, USPSTF member and coauthor of Screening for Hypertension in Children and Adolescents

Interview with Carlos del Rio, MD, author of Long-term Health Consequences of COVID-19 Related Article: Long-term Health Consequences of COVID-19

Anthony S. Fauci, MD, returns to JAMA's Q&A series to discuss the latest developments in the COVID-19 pandemic, including the continued importance of nonpharmaceutical interventions (masking, handwashing, physical distancing) for managing rising case numbers in the US and globally. Recorded October 28, 2020. Related Article(s): Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

Paul A. Offit, MD, of the Children's Hospital of Philadelphia, returns to JAMA's Q&A series to provide an update on progress in COVID-19 vaccine development. Recorded October 27, 2020. Related Article(s): Developing a SARS-CoV-2 Vaccine at Warp Speed

Interview with Kathryn A. Phillips, PhD, author of Expanding Use of Clinical Genome Sequencing and the Need for More Data on Implementation   Related content: Functional Neurological Disorder Society

Rochelle P. Walensky, MD, MPH, of Harvard Medical School and Massachusetts General Hospital returns to JAMA's COVID-19 Q&A to provide an update on developments in the pandemic. She is a signatory of the recent John Snow Memorandum emphasizing the importance of public health interventions to manage the spread of COVID-19. Recorded October 22, 2020. Related Article(s): Preventing the Spread of SARS-CoV-2 With Masks and Other “Low-tech” Interventions

The costs of the coronavirus pandemic are unprecedented in their dimensions: David M. Cutler, PhD, of Harvard University discusses financial costs: the $16 trillion virus. Lisa Cooper, MD, MPH, of Johns Hopkins University discusses the costs to communities of color in excess deaths and bereavement. Charles R. Marmar, MD, of NYU Grossman School of Medicine discusses the mental health costs. Recorded October 20, 2020. Related Article(s): The COVID-19 Pandemic and the $16 Trillion Virus

Andy Slavitt, MBA, discusses recent developments in the COVID-19 pandemic and the US response. Slavitt is former Acting CMS Administrator in the Obama administration, board director at the United States of Care in Washington, DC, and a Distinguished Health Policy Fellow at the Leonard Davis Institute of Health Economics at the University of Pennsylvania in Philadelphia. Recorded October 16, 2020. Related Article: The COVID-19 Pandemic Underscores the Need to Address Structural Challenges of the US Health Care System

The National Academy of Medicine has recommended that racial minority populations receive priority for vaccination because they have been hard hit by the pandemic and are "worse off" socioeconomically. US law is inconsistent on whether race/ethnicity can be an explicit criterion for achieving equity and diversity. Lawrence O. Gostin, JD, of Georgetown University and Michelle A. Williams, ScD, of Harvard T.H. Chan School of Public Health discuss ways to achieve the public health objective of protecting vulnerable communities while adhering to law and ethics. Recorded October 14, 2020. Related Article(s): Is It Lawful and Ethical to Prioritize Racial Minorities for COVID-19 Vaccines?

Interview with Christopher W. Seymour, MD, MSc, author of Sensible Medicine—Balancing Intervention and Inaction During the COVID-19 Pandemic

The US Surgeon General’s office has released a report emphasizing the importance of making hypertension control a national public health priority. Vice Admiral Jerome Adams, MD, MPH, the 20th US Surgeon General, discusses the report's background and recommendations. Recorded October 7, 2020. Related Article(s): A National Commitment to Improve the Care of Patients With Hypertension in the US

On October 2 the US National Academies of Science, Engineering, and Medicine issued its consensus Framework for Equitable Allocation of a COVID-19 Vaccine. William H. Foege, MD, MPH, emeritus distinguished professor of International Health at the Rollins School of Public Health at Emory University, cochaired the committee that authored the report and discusses its recommendations. Recorded October 2, 2020. Related Article: Fairly Prioritizing Groups for Access to COVID-19 Vaccines

Peter Marks, MD, PhD, directs the US FDA's Center for Biologics Evaluation and Research (CBER) and will "call the balls and strikes" on any COVID-19 vaccine, according to FDA Commissioner Stephen Hahn. He joins JAMA Editor Howard Bauchner, MD, for an update on vaccine progress to date and prospects for pre-election political interference in the FDA approval process. Recorded October 5, 2020. Related Article(s): Unwavering Regulatory Safeguards for COVID-19 Vaccines

Interview with William H. Shrank, MD, author of De-adopting Low-Value Care: Evidence, Eminence, and Economics Related Article(s): De-adopting Low-Value Care

Anthony S. Fauci, MD, returns to JAMA's Q&A series to discuss the latest developments in the COVID-19 pandemic. Recorded September 25, 2020. Related Article(s): Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine

Michael T. Osterholm, PhD, MPH, returns to JAMA's Coronavirus Q&A series to discuss the latest developments in the COVID-19 pandemic. He is director of the Center for Infectious Disease Research and Policy (CIDRAP) at University of Minnesota and a veteran of pandemic planning. Recorded September 23, 2020. Related Article(s): Fairly Prioritizing Groups for Access to COVID-19 Vaccines

Hydroxychloroquine and convalescent plasma approvals by the FDA under Emergency Use Authorization (EUA) protocols have raised concerns the agency is under withering political pressure to fast-track a COVID-19 vaccine before it is proven safe and effective. Joshua Sharfstein, MD, Johns Hopkins Bloomberg School of Public Health, and JAMA Associate Editor Preeti Malani, MD, University of Michigan, discuss implications for public health and policy responses to ensure vaccine safety. Recorded September 18, 2020. Related Article: Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine

Interview with Aaron S. Kesselheim, MD, author of Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency Related Article(s): Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency

Interview with Atul J Butte, MD, PhD, author of The Case for Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies Related Article: The Case for Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies

New data show unfavorable US trends in hypertension and obesity, with communities of color doing worse. National Institute of Diabetes and Digestive and Kidney Diseases Director Griffin P. Rodgers, MD, and National Heart, Lung, and Blood Institute Director Gary H. Gibbons, MD, discuss the implications for COVID-19 outcomes and public health. Recorded September 10, 2020. Related Article(s): Trends in Blood Pressure Control Among US Adults With Hypertension, 1999-2000 to 2017-2018

Interview with Deborah Korenstein, MD, and Daniel J. Morgan, MD, author of Improving Physician Communication About Treatment Decisions: Reconsideration of “Risks vs Benefits” Related Article(s): Improving Physician Communication About Treatment Decisions

A conversation with Jonathan A. C. Sterne, MA, MSc, PhD, of the University of Bristol, Todd W. Rice, MD, MSc, of Vanderbilt University, and Janet V. Diaz, MD, of the World Health Organization (WHO) on the latest research supporting the use of hydrocortisone and dexamethasone for treatment of COVID-19 ARDS. Recorded September 2, 2020. Related Article(s): Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19

Interview with Catherine Lucey, MD, FACP, author of The Transformational Effects of COVID-19 on Medical Education

Paul A. Offit, MD, of the Children's Hospital of Philadelphia provides an update on COVID-19 vaccine development. Recorded August 24, 2020. Related Article: Developing a SARS-CoV-2 Vaccine at Warp Speed

CDC Director Robert Redfield, MD, discusses recent developments in the COVID-19 pandemic and US response, including prospects for dual outbreaks of COVID-19 and influenza in the fall and winter. Related Article(s): Addressing Influenza Vaccination Disparities During the COVID-19 Pandemic

Ezekiel Emanuel, MD, PhD, of the University of Pennsylvania's Perelman School of Medicine, Department of Medical Ethics and Health Policy, discusses recent developments in the COVID-19 pandemic. Recorded August 19, 2020. Related Article(s): The Ethics of COVID-19 Immunity-Based Licenses (“Immunity Passports”)

Interview with Melissa A Simon, MD, USPSTF member and coauthor of Behavioral Counseling Interventions to Prevent Sexually Transmitted Infections: US Preventive Services Task Force Recommendation Statement Related Article(s): Behavioral Counseling Interventions to Prevent Sexually Transmitted Infections

Interview with Matcheri S. Keshavan, MD, author of The Convergence of Neurology and Psychiatry: The Importance of Cross-Disciplinary Education

Soumya Swaminathan, MD, DNB, chief scientist at the World Health Organization (WHO), discusses the global coronavirus pandemic and the WHO response. Recorded August 5, 2020. Related Article: COVID-19 Reveals Urgent Need to Strengthen the World Health Organization

Anthony Fauci, MD, White House Coronavirus Task Force member and director of the National Institute of Allergy and Infectious Diseases, discusses latest developments in the COVID-19 pandemic. Recorded August 3, 2020. Related Article(s): Anthony Fauci, MD, on COVID-19 Vaccines, Larry Kramer, and Dealing With Criticism

US Food and Drug Administration (FDA) Commissioner Stephen Hahn, MD, discusses the agency's role in responding to the COVID-19 pandemic. Recorded July 30, 2020. Related Article: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)

The World Brain Death Project was undertaken to establish minimum standards for diagnosing brain death/death by neurologic criteria (BD/DNC) in children and adults across a broad range of settings and clinical circumstances. In this Q&A, senior authors of the 2020 report join an editorialist and bioethicist to discuss the project. Featuring interviews with Gene Sung, MD, of the University of Southern California; Ariane Lewis, MD, of NYU Langone Medical Center; Robert Tasker, MD, of the University of Cambridge; and Robert D. Truog, MD, of Harvard University. Related Article(s): Brain Death—Moving Beyond Consistency in the Diagnostic Criteria

Katherine Auger, MD, MSc, of Cincinnati Children's Hospital and Julie Donohue, PhD, of University of Pittsburgh's Graduate School of Public Health discuss K-12 school reopening policy options and the way forward for the 2020-21 school year. Recorded July 29, 2020. Related Article: Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US

Interview with Jan M. Friedman, MD, PhD, author of Exome Sequencing and Clinical Diagnosis Related Article(s): Exome Sequencing and Clinical Diagnosis

Ford Foundation President Darren Walker discusses the role of philanthropic organizations in responding to the COVID-19 pandemic and to health inequities. Recorded July 28, 2020. Related Article(s): The Work of Philanthropy in Responding to COVID-19 and Addressing Inequality

Interview with Neil R. Powe, MD, author of Black Kidney Function Matters: Use or Misuse of Race?

Eric Topol, MD, Scripps Research EVP and omnivorous science health care and tech commentator, discusses the evolving COVID-19 pandemic. Recorded July 23, 2020. Related Article: Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers

Interview with Adrian F. Hernandez, MD, author of National Hospital Quality Rankings: Improving the Value of Information in Hospital Rating Systems

CDC Director Robert R. Redfield, MD, discusses the ongoing COVID-19 pandemic and the agency’s latest recommendations. Recorded July 14, 2020. Related Article: Universal Masking to Prevent SARS-CoV-2 Transmission—The Time Is Now

Interview with Michelle D. Carlson, MD, author of Assessing Quantitative Comparisons of Health and Social Care Between Countries Related Article(s): Assessing Quantitative Comparisons of Health and Social Care Between Countries

Kalpalatha K. Guntupalli, MD, of Baylor College of Medicine discusses the surge and ICU management of COVID-19 patients in Houston, Texas. Recorded July 10, 2020. Related Article(s): Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Infectious disease physician Rochelle P. Walensky, MD, MPH, of Harvard University discusses the ongoing COVID-19 pandemic. Recorded July 8, 2020. Related Article: Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection

Anthony Fauci, MD, White House Coronavirus Task Force member and Director of the National Institutes of Allergy and Infectious Diseases, discusses latest developments in the COVID-19 pandemic. Recorded on July 2, 2020. Watch the interview

Interview with Benjamin D. Horne, PhD, author of Limited Evidence for the Health Effects and Safety of Intermittent Fasting Among Patients With Type 2 Diabetes Related Article: Limited Evidence for the Health Effects and Safety of Intermittent Fasting Among Patients With Type 2 Diabetes

Anne Schuchat, MD, Principal Deputy Director of the Centers for Disease Control and Prevention (CDC), discusses latest developments in the COVID-19 pandemic. Recorded on June 29, 2020. Related Article(s): Interpreting Diagnostic Tests for SARS-CoV-2

Intensivists Flavia R. Machado, MD, PhD, of the Federal University of São Paulo, and Jorge Salluh, MD, PhD, of the D’OR Institute for Research and Education in Rio de Janeiro, discuss the surge of COVID-19 cases and ICU management of patients in Brazil. Recorded June 26, 2020. Related Article(s): Latin America and Its Global Partners Toil to Procure Medical Supplies as COVID-19 Pushes the Region to Its Limit

Michael Osterholm, PhD, MPH, of UMN’s Center for Infectious Disease Research and Policy, discusses the summer rise in US COVID-19 cases, prospects for school reopening, a "second wave" in the fall, and more. Recorded June 24, 2020. Related Article(s): Vulnerability to Pandemic Flu Could Be Greater Today Than a Century Ago

Infectious disease and global health expert Carlos del Rio, MD, of Emory University provides an update on the status of the #COVID19 pandemic in summer 2020, prospects for effective treatment and prevention, communicating the ongoing risk to the public, and more. Recorded June 15, 2020. Related Article: Translating Science on COVID-19 to Improve Clinical Care and Support the Public Health Response

Interview with Howard K. Koh, MD, author of Sustainability, Business, and Health Related Article(s): Sustainability, Business, and Health

Interview with William H. Shrank, MD, author of Hospice Carve-In—Aligning Benefits With Patient and Family Needs Related Article: Hospice Carve-In—Aligning Benefits With Patient and Family Needs

COVID-19 critical care update with Maurizio Cecconi, MD, of Humanitas University in Milan, Italy, and JAMA Associate Editor Derek C. Angus, MD, MPH, of the University of Pittsburgh. Recorded June 8, 2020. Related: Management of COVID-19 Respiratory Distress

Interview with Karina W. Davidson, PhD, USPSTF member and coauthor of Screening for Unhealthy Drug Use: US Preventive Services Task Force Recommendation Statement

Interview with Anthony L. Komaroff, MD, author of Can Infections Cause Alzheimer Disease?

Joshua M. Sharfstein, MD, and Christopher Morphew, PhD, of Johns Hopkins University discuss options for opening primary, middle, and high schools in fall 2020. Recorded June 3, 2020. Related Article: The Urgency and Challenge of Opening K-12 Schools in the Fall of 2020

NIAID Director Anthony Fauci, MD, discusses recent developments in the global COVID-19 pandemic with JAMA Editor in Chief Howard Bauchner, MD. Recorded June 2, 2020. Related Article: Anthony Fauci, MD, on COVID-19 Vaccines, Larry Kramer, and Dealing With Criticism

Paul Offit, MD, of the Children's Hospital of Philadelphia, discusses principles and progress to date in COVID-19 vaccine development. Recorded June 1, 2020. Related: Adverse Consequences of Rushing a SARS-CoV-2 Vaccine: Implications for Public Trust

Paul Starr, PhD, Professor of Sociology and Public Affairs at Princeton University, discusses policy options for achieving a new normal in the COVID-19 pandemic. Recorded Thursday, May 28, 2020. Related Article: Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic

Interview with Zirui Song, M.D., Ph.D., author of Potential Implications of Lowering the Medicare Eligibility Age to 60

Interview with Humayun J. Chaudhry, DO, author of The USMLE Step 1 Decision: An Opportunity for Medical Education and Training

Interview with Michael Silverstein, MD, MPH, USPSTF member and coauthor of Primary Care–Based Interventions to Prevent Illicit Drug Use in Children, Adolescents, and Young Adults: US Preventive Services Task Force Recommendation Statement

US National Institutes of Health (NIH) Director Francis S. Collins, MD, PhD, discusses the agency's new initiative to collaborate with other agencies and industry to accelerate development and testing of COVID-19 treatments and vaccines. Recorded May 19, 2020. Related: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): An Unprecedented Partnership for Unprecedented Times

Ezekiel Emanuel, MD, PhD, of the Perelman School of Medicine's Department of Medical Ethics and Health Policy, discusses the use of immunity licensing (immunity passports) as a means to restore public travel, activity, and the economy following the first wave of the COVID-19 pandemic. Recorded May 11, 2020. Related: The Ethics of COVID-19 Immunity-Based Licenses (“Immunity Passports”)

Interview with Paul J. Young, PhD, author of When Should Clinicians Act on Non–Statistically Significant Results From Clinical Trials?

Don Berwick, MD, MPP, of the Institute for Healthcare Improvement, discusses choices societies and the medical profession can make to improve health care and reduce inequities as we move out of the acute phase of the coronavirus pandemic. Related Article(s): Choices for the “New Normal”

Anne Schuchat, MD, Principal Deputy Director of the Centers for Disease Control and Prevention (CDC), discusses evolution of CDC guidance and latest developments in the COVID-19 pandemic. Recorded Friday May 1, 2020.

Interview with Robert D. Truog, MD, MA, author of Understanding Brain Death

The US spends more on health care as a proportion of its GDP than any other nation. Will the COVID-19 pandemic reduce or accelerate that spending? Sherry Glied, PhD, Dean and Professor of Public Service at New York University, explains. Recorded Monday, April 27, 2020. Read the article The Potential Effects of Coronavirus on National Health Expenditures

Interview with Michael Silverstein, MD, MPH, USPSTF member and coauthor of Primary Care Interventions for Prevention and Cessation of Tobacco Use in Children and Adolescents: US Preventive Services Task Force Recommendation Statement

Marc Lipsitch, DPhil, an infectious diseases epidemiologist developing biological and modeling approaches to pathogen transmission and outbreaks, discusses evolution of the COVID-19 pandemic in summer and fall 2020. Originally recorded April 22, 2020.

Interview with Aaron S. Kesselheim, MD, JD, MPH, author of Increasing Access to FDA Inspection Reports on Irregularities and Misconduct in Clinical Trials

Rochelle Walensky, MD, MPH, of Harvard University discusses public health strategies and policies for lifting shelter-in-place and quarantine and for returning the US to a new post-first-wave normal. Recorded Monday April 20, 2020.

Interview with Madison Kilbride, PhD, author of The Need to Improve the Clinical Utility of Direct-to-Consumer Genetic Tests: Either Too Narrow or Too Broad

JAMA Health Forum editors John Ayanian, MD, MPP, and Melinda Buntin, PhD, discuss changes in US health care and health policy driven by the coronavirus pandemic. Recorded April 16, 2020.

Interview with Jeffrey A. Linder, MD, author of Delayed Antibiotic Prescriptions in Ambulatory Care: Reconsidering a Problematic Practice

New York City coronavirus update from Mitchell Katz, MD, President and CEO of NYC Health + Hospitals, the largest municipal public health system in the United States. Recorded April 13, 2020.

NIAID Director and Presidential Coronavirus Task Force Advisor Anthony Fauci, MD, discusses recent developments in the global COVID-19 pandemic with JAMA Editor Howard Bauchner, MD. Recorded April 8, 2020.

US states are taking the lead in managing the COVID-19 pandemic. What can state governors expect from the federal government and from the US Department of Health and Human Services? Governor Mike Leavitt from Leavitt Partners joins JAMA Editor Howard Bauchner, MD, in this live Q&A. Recorded April 8, 2020.

Questions about testing, chloroquine toxicity, duration of immunity and reinfection, and what to expect next are gripping the US as the novel coronavirus spreads. JAMA Associate Editor Preeti Malani, MD, professor of medicine and Chief Health Officer at the University of Michigan, discusses recent developments in a live conversation with JAMA Editor in Chief Howard Bauchner. Recorded on April 6, 2020.

Interview with Chien-Wen W Tseng, MD, MPH, USPSTF member and coauthor of Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery: US Preventive Services Task Force Recommendation Statement

Infectious epidemics have always driven change and triggered discrimination in human societies. Frank Snowden, DPhil, Professor Emeritus of History and History of Medicine at Yale University and author of Epidemics and Society: From the Black Death to the Present (Yale University Press, 2019), puts the COVID-19 pandemic in historical context.

Interview with Sandro Galea, MD, author of The Role of Physicians in Addressing Social Determinants of Health

Noninvasive ventilation (NIV), working with dying patients’ families, use of experimental therapies, and more. JAMA Associate Editor Derek Angus, MD, MPH, Distinguished Professor and Chair of Critical Care Medicine at the University of Pittsburgh, provides a COVID-19 ICU management update. Watch the recording of this livestream

How does the current pandemic compare to historical infectious outbreaks and what can we expect in summer and fall of 2020? Nicholas Christakis, MD, PhD, MPH, director of the Human Nature Lab, Co-director of the Institute of Network Science, and Sterling Professor of Social and Natural Science at Yale University, discusses the epidemiology of COVID-19.

Hospitals need ways to make rational, fair decisions about who gets ICU beds and ventilators if COVID-19 patients overwhelm capacity. Douglas B. White, MD, MAS, Director of the Program on Ethics and Decision Making in Critical Illness at the University of Pittsburgh, discusses a framework for those decisions and a guideline he helped develop for allocation of scarce resources in public health emergencies.

As COVID-19 spreads globally, populations who survive their illness will become immune. Mayo Vaccine Research Group Director Gregory Poland, MD, discusses antibody responses, duration of immunity, vaccine safety, and the prospects for using convalescent serum to passively immunize people unexposed to SARS-CoV-2.

The ARDS in COVID-19 patients appears more responsive to PEEP and prone ventilation, but seems to require prolonged ventilation and may be associated with myocardial injury. Michelle N. Gong, MD, MS, Chief of Critical Care Medicine at Montefiore Medical Center in the Bronx, discusses her department's experience managing critically ill coronavirus patients, procuring diagnostic tests and personal protective equipment (PPE) for her staff, and more.

The strategy for managing the COVID-19 pandemic has shifted from containment to mitigation. What does that mean for US hospitals and health systems? Kaiser Permanente Executive Vice President Stephen M. Parodi, MD, discusses telemedicine, protecting health care workers, equipment allocation planning, and more.

Diagnostic testing, NSAIDs, ACE Inhibitors, antivirals, and more. Anthony Fauci, MD from NIAID discusses latest developments in the spread and clinical management of COVID-19 and the SARS-CoV-2 virus with JAMA Editor Howard Bauchner, MD. JAMA Coronavirus Resource Center

Coronavirus testing will help countries manage coronavirus disease 2019 (COVID-19) but will raise questions about how to counsel patients about their test results. The CDC's Deputy Director for Infectious Diseases Jay C. Butler, MD, talks with JAMA Editor Howard Bauchner about what to advise healthy patients with positive PCR results, sick patients with negative test results, exposed health care workers, and more.

Physicians in Lombardy, Italy, have been overwhelmed by COVID-19 patients requiring critical care. Based on an existing ECMO center network they developed an ICU network to rapidly identify, triage, and manage patients infected with SARS-2-CoV. Maurizio Cecconi, MD, of Humanitas University in Milan discusses the region’s approach to the surge, including clinical and supply management, health care worker training and protection, and ventilation strategies, with JAMA Editor Howard Bauchner. Read the article: Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response

Interview with Victor M. Montori, MD, MSC, author of When Guidelines Recommend Shared Decision-making

Coronavirus testing, mortality, vaccine development, containment vs mitigation, and more. JAMA Editor Howard Bauchner, MD, interviews US NIAID Director Anthony Fauci, MD, about the latest developments in SARS-CoV-2 science and global spread of infection. JAMA Coronavirus Resource Page

Interview with Michael J. Barry, MD, Task Force member and coauthor of Screening for Hepatitis C Virus Infection in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

Interview with Jonathan A. Patz, MD, MPH, author of A Low-Carbon Future Could Improve Global Health and Achieve Economic Benefits

Interview with Ezekiel J. Emanuel, M.D., Ph.D., author of The Inevitable Reimagining of Medical Education

Interview with Chyke A Doubeni, MD, MPH, author of Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement

Interview with David Naylor, MD DPhil, author of The Evolution of Schools of Thought in Medicine: Healthy Tensions

JAMA Author Interviews is taking on a new look! Be sure to subscribe to Conversations with Dr Bauchner, a podcast that features the same insightful interviews with leading researchers and thinkers in health care. Covering a broad range of practice-changing research and important innovations, Conversations with Dr Bauchner is a convenient way to stay current with the most pressing issues facing medicine and healthcare. Listen and subscribe at jamanetworkaudio.com.

By mid-February 2020 there were 60,000 confirmed cases of COVID-19, the vast majority diagnosed in Hubei Province (including Wuhan city) in mainland China. China CDC Chief Epidemiologist Zunyou Wu, MD, PhD discusses the latest COVID-19 developments in the country with JAMA Editor in Chief Howard Bauchner, MD.

In February 2020 the nature of the 2019-nCoV outbreak is still slowly coming into focus but it appears to be acting more like bad pandemic influenza (efficient spread, overall lower mortality) than like SARS (less efficient spread, overall higher mortality). Anthony Fauci, MD, of the US National Institute of Allergy and Infectious Diseases (NIAID) discusses the latest developments with JAMA Editor in Chief Howard Bauchner. Coronavirus Resource Center

Interview with Jenny A. Doust, BMBS, author of Potential Consequences of Changing Disease Classifications

Interview with Martin A. Makary, MD, MPH, author of Billing Quality Is Medical Quality

Interview with Jack Resneck, MD, author of Refocusing Medication Prior Authorization on Its Intended Purpose

Interview with Anthony S. Fauci, MD, author of Coronavirus Infections—More Than Just the Common Cold

Interview with I Glenn. Cohen, JD, author of Ethical and Legal Aspects of Ambient Intelligence in Hospitals

Interview with Maya M. Hammoud, MD, MBA, author of Improving the Residency Application and Selection Process: An Optional Early Result Acceptance Program

Interview with Donna Michelle Zulman, MD, and Abraham Verghese, MD, authors of Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter

Interview with Claire J. Creutzfeldt, MD, author of Treatment Decisions for a Future Self: Ethical Obligations to Guide Truly Informed Choices

Interview with Julia A. Segre, Ph.D., author of Manipulating the Human Microbiome to Manage Disease

Interview with Mercedes R. Carnethon, PhD, author of Disparities Research, Disparities Researchers, and Health Equity

Interview with Anthony S. Fauci, MD, author of Comorbidities in Persons With HIV: The Lingering Challenge

Interview with Michael J. Barry, MD, USPSTF member and coauthor of Screening for Abdominal Aortic Aneurysm: US Preventive Services Task Force Recommendation Statement

Interview with Mark D. Huffman, MD, MPH, author of Implementation Strategies for Cardiovascular Polypills

Interview with Amol S. Navathe, MD, PhD, author of Addressing Bias in Artificial Intelligence in Health Care

Interview with Stephen Baldassarri, author of Vaping—Seeking Clarity in a Time of Uncertainty

Interview with Pascale Carayon, PhD, author of Improving the System to Support Clinician Well-being and Provide Better Patient Care

Interview with John P. A. Ioannidis, MD, DSc, author of Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science

Interview with Deborah Dowell, M.D., M.P.H., author of Patient-Centered Reduction or Discontinuation of Long-term Opioid Analgesics: The HHS Guide for Clinicians

Interview with William H. Shrank, MD, MSHS, author of Waste in the US Health Care System: Estimated Costs and Potential for Savings

Interview with S Claiborne Johnston, MD, PhD, author of The Risk and Cost of Limited Clinician and Patient Accountability in Health Care

Interview with Melissa A. Simon, MD, MPH, Task Force member and coauthor of Screening for Asymptomatic Bacteriuria in Adults: US Preventive Services Task Force Recommendation Statement

Interview with Francisco G. Cigarroa, MD, author of The Advancing American Kidney Health Executive Order: An Opportunity to Enhance Organ Donation

Interview with Frank B. Hu, MD, PhD, author of Can Plant-Based Meat Alternatives Be Part of a Healthy and Sustainable Diet?

Interview with Benjamin Daniel Sommers, MD, PhD, author of Medicaid Expansion and Health: Assessing the Evidence After Five Years

Interview with Anna D. Sinaiko, Ph. D., author of What Is the Value of Market-Wide Health Care Price Transparency?

Interview with Michael J. Barry, MD, USPSTF member and coauthor of Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Yngvild Olsen, M.D., M.P.H., author of Lessons Learned From the Opioid Epidemic

Interview with Karina W. Davidson, PhD, MASc, author of Screening for Social Determinants of Health: The Known and Unknown

Interview with Carol M Mangione, MD MSPH, USPSTF member and coauthor of Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement Audio at 5:55 was changed to reflect a revised risk increase statement.  

Interview with Joanna Paladino, MD, author of Communication Strategies for Sharing Prognostic Information With Patients: Beyond Survival Statistics

Interview with Daniel Brodie, MD, author of Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review

Interview with Alexandra K. Glazier, JD, MPH, author of Success of Opt-In Organ Donation Policy in the United States

Interview with Gary H. Gibbons, M.D., author of Accelerating the Science of SCD Therapies—Is a Cure Possible?

Interview with Chyke A Doubeni, MD, MPH, USPSTF member and coauthor of Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement

Interview with Michael Nurok, MBChB, PhD, author of Relative Value Units and the Measurement of Physician Performance

Interview with Robert M. Wachter, MD, author of Reimagining Specialty Consultation in the Digital Age: The Potential Role of Targeted Automatic Electronic Consultations

Interview with Jennifer L. Swails, MD, author of The Conundrum of the United States Medical Licensing Examination Score Reporting Structure

Interview with Melissa A Simon, MD MPH, USPSTF member and coauthor of Screening for Hepatitis B Virus Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement

Interview with Randall S. Stafford, MD, PhD, MHS, author of A Practical Approach to Low-Dose Aspirin for Primary Prevention

Interview with S. Claiborne Johnston, MD, PhD, author of Academic Medical Centers: Too Large for Their Own Health?

Interview with John W Epling, MD, MSEd, Task Force member and co-author of Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement

Interview with Paul A. Volberding, MD, and Hyman Scott, MD MPH, authors of HIV Screening and Preexposure Prophylaxis Guidelines: Following the Evidence

Interview with Marissa A. Hendrickson, MD, author of The Review of Systems, the Electronic Health Record, and Billing

Interview with Anthony S. Fauci, MD, author of Durable Control of HIV Infection in the Absence of Antiretroviral Therapy: Opportunities and Obstacles

Interview with Alan Leshner, PhD, author of Medication-Based Treatment to Address Opioid Use Disorder

Interview with Andrew A. Nierenberg, MD, author of Evolving Issues in the Treatment of Depression

Interview with Robert M. Wachter, MD, author of Restricting the Number of Open Patient Records in the Electronic Health Record: Is the Record Half Open or Half Closed?

Interview with David M. Cutler, PhD, author of Life and Death in Norway and the United States

Interview with Nancy L. Keating, MD, MPH, author of New Federal Requirements to Inform Patients About Breast Density: Will They Help Patients?

Interview with Benjamin Tolchin, MD, MS, author of Treatment of Patients With Psychogenic Nonepileptic Attacks

Interview with Robert M. Califf, MD, author of Lowering Cost and Increasing Access to Drugs Without Jeopardizing Innovation

Interview with Michael Silverstein, MD, MPH, USPSTF member and coauthor of Screening for Elevated Blood Lead Levels in Children and Pregnant Women: US Preventive Services Task Force Recommendation Statement

Interview with John A. Baron, M.D., author of Vitamin D as Cancer Therapy?: Insights From 2 New Trials

Interview with Kevin A. Schulman, MD, author of The Implications of “Medicare for All” for US Hospitals

Interview with David A. Asch, MD, MBA, author of The Uncertain Effect of Financial Incentives to Improve Health Behaviors

Interview with Neil Skolnik, M.D., author of Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults

Interview with Ezekiel J. Emanuel, M.D., Ph.D., author of Next Phase in Effective Cost Control in Health Care

Interview with Elizabeth O'Connor, PHD, author of Interventions to Prevent Perinatal Depression: Evidence Report and Systematic Review for the US Preventive Services Task Force

Interview with Sonoo Thadaney-Israni, MBA, and Abraham Verghese, MD, MACP, authors of Humanizing Artificial Intelligence

Interview with Alex R Kemper, MD, MPH, MS, Task Force member and co-author of Interventions to Prevent Child Maltreatment: US Preventive Services Task Force Recommendation Statement

Interview with Susan J. Curry, PhD, author of Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

Interview with John W Epling, MD, MSEd, Task Force member and co-author of Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: US Preventive Services Task Force Final Recommendation Statement

Interview with Chyke A Doubeni, M.D., F.R.C.S., M.P.H., Task Force member and co-author of Behavioral Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: US Preventive Services Task Force Recommendation Statement

Interview with Carol M Mangione, MD MSPH, Task Force member and co-author of Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Seth Landefeld, MD, member of the US Preventative Services Task Force, on  Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement

Interview with Michael J. Barry, MD, Task Force member and co-author of Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment With the Ankle-Brachial Index: US Preventive Services Task Force Recommendation Statement

Interview with Chien-Wen Tseng, MD, MPH, Task Force member and co-author of Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement

Interview with Seth Landefeld, MD, Task Force member and co-author of Screening for Cardiovascular Disease Risk With Electrocardiography: US Preventive Services Task Force Recommendation Statement

Interview with Alex H Krist, MD, MPH, Task Force member and co-author of Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Alex H Krist, MD, MPH, Task Force member and co-author of Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: US Preventive Services Task Force Recommendation Statement, and Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement

Interview with Christopher JL. Murray, MD, DPhil, author of The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States

Interview with John W Epling, MD, MSEd, Task Force member and co-author of Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Dr. Ashish Jha, MD, MPH, about his study using Organization for Economic Cooperation and Development (OECD) data to compare health care infrastructure, outcomes, and prices in the US and other high-income countries to identify the sources of spending that make US health care so expensive.    

Interview with Michael J. Barry, MD, Task Force member and co-author of Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Alex R Kemper, MD, MPH, MS, Task Force member and co-author of Screening for Adolescent Idiopathic Scoliosis: US Preventive Services Task Force Recommendation Statement

Interview with Maureen Phipps, MD, Task Force member and co-author of Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement

Interview with Jeffrey Alan. Golden, MD, author of Deep Learning Algorithms for Detection of Lymph Node Metastases From Breast Cancer: Helping Artificial Intelligence Be Seen

Interview with JoAnn E. Manson, MD, DrPH, author of Menopausal Hormone Therapy and Long-Term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials

Interview with Alex R Kemper, MD, MPH, MS, Task Force member and co-author of Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Force Recommendation Statement

Interview with Stuart M. Butler, PhD, MA, BSc, author of State Flexibility for Medicaid: How Much?

Interview with Ann C. McKee, M.D., author of Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

Interview with Susan J. Curry, PhD, author of Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Risk Factors: US Preventive Services Task Force Recommendation Statement

Interview with David C. Grossman, MD, MPH, author of Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Recommendation Statement

Interview with Timothy E. McAlindon, MD,MPH, author of Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

Whole-genome sequencing is now easily done for very little cost. It is not known how to interpret the results of this testing. Healthy individuals should not have this performed. If someone has a reason to suspect a particular disease with a known genetic association, then whole-genome or targeted sequencing is reasonable to pursue.

Interview with Charles Landefeld, MD, author of Screening for Thyroid Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Maureen G. Phipps, MD, MPH, Task Force member and co-author of Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement

Interview with Gail Hayward, MA (Oxon) D.Phil MRCP MRCGP, author of Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial

This podcast discusses the latest research into the workings of the lung microbiome and how it will affect future diagnosis and treatment of respiratory diseases. Related article: The Lung Microbiome: Key to Respiratory Ills?

This Medical News podcast features an interview with Barry Marshall, MD, who codiscovered the stomach bug H pylori in 1982.

Interview with Alex H Krist, MD, MPH, Task Force member and co-author of Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement

Interview with Freddie C. Hamdy, MD, FRCSEd(Urol), and Jenny L Donovan, PhD, FMedSci, authors of Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer: Helping Decision Making for Patients and Their Physicians

Recent guidelines for how to best manage septic shock have changed. Gone are recommendations for central venous oxygen saturation monitoring and goal-directed therapy. In is the concept that septic shock be treated as an emergency with rapid administration of antibiotics and large amounts of fluids. Our discussants Derek C. Angus, MD, MPH, and Michael D. Howell, MD, MPH, discuss why these recommendations have changed. This is the second podcast in the Surviving Sepsis guideline series. The first podcast reviewed what recommendations are in the guideline itself. Article discussed in this episode: Management of Sepsis and Septic Shock Speakers: JAMA Associate Editor Derek C. Angus, MD, MPH, University of Pittsburgh, and Michael D. Howell, MD, MPH, University of Chicago.

Interview with Maureen G. Phipps, MD, MPH, Task Force member and co-author of Screening for Gynecologic Conditions With Pelvic Examination: US Preventive Services Task Force Recommendation Statement

In 2017 the Society for Critical Care Medicine updated its guidelines for sepsis management. These new guidelines differ significantly from ones in the past in that they no longer recommend protocolized resuscitation and emphasize early and aggressive fluid resuscitation when patients present with septic shock. This is the first podcast in the Surviving Sepsis guideline series. The next episode discusses why the new sepsis guideline changed. Article discussed in this episode: Management of Sepsis and Septic Shock Speakers: Laura Evans, MD, MSc, of Bellevue Hospital and NYU Medical Center Andrew Rhodes, MBBS, MD, of St George’s University Hospitals NHS Trust and co-chair of the Surviving Sepsis guideline panel Mitchell M. Levy, MD, of the Alpert Medical School of Brown University and Rhode Island Hospital  

Can testosterone gel improve memory, correct anemia, increase bone density or prevent the growth of coronary artery plaque in older men with low testosterone levels? Four new studies in JAMA and JAMA Internal Medicine found improvement in some of these measures. Articles discussed in this episode: • Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone • Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment • Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial • Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial

Rudolph Tanzi, PhD, of Harvard University, and Berislav Zlokovic, MD, PhD, of the University of Southern California, discuss what the future holds for Alzheimer Disease research and treatment.

Interview with Julie Rani Nangia, BA, MD, author of Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial, and Hope S. Rugo, MD, author of Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer

Workplace violence–related injuries occur disproportionately in health care settings. In this podcast, we discuss how individual clinicians should manage violent patients who might attack them. Article discussed in this episode: Ensuring Staff Safety When Treating Potentially Violent Patients

Interview with Alex H. Krist, MD, MPH, Task Force member and co-author of Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement

Interview with Alex R. Kemper, MD, MPH, MS, Task Force member and co-author of Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement

Violence against health care workers is increasing. With fewer mental health services available, health care workers have disproportionate exposure to potentially dangerous patients. This article reviews the experience of one nurse who was severely injured by a patient and the lessons learned by the hospital where the incident occurred regarding minimizing the risk of staff injury when providing care for potentially violent patients. We interview Robert P. Roca, MD, MPH, MBA; Antonio DePaolo, PhD; Ernestine Cosby, RN; and Bolarin Kehinde, RN, to shed light on this serious issue. Article discussed in this episode: Ensuring Staff Safety When Treating Potentially Violent Patients  

Between 8% and 10% of the population will have a seizure at one point in life. It's important to distinguish seizures from other entities that can look like them and, once a diagnosis of a seizure is established, know how to treat them. In this JAMA Clinical Review podcast, we discuss seizures and epilepsy with Jay Gavvala, MD, author of New-Onset Seizure in Adults and Adolescents: A Review. Article discussed in this episode: New-Onset Seizure in Adults and Adolescents: A Review  

Interview with Ann E. Kurth, PhD, RN, MSN, MPH, author of Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Recommendation Statement

Interview with Roger L. Zemek, MD, author of Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents

Interview with Jennifer Abbasi, author of NIH Charts a Path for Nutrition Science

Interview with Christopher JL. Murray, MD, DPhil, author of US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014

Approximately one-third of all medical school graduates report having been abused as students. Medical student and resident abuse has long been considered unacceptable behavior but still persists in the teaching environment. In this podcast we discuss how students and residents might respond to these events. We interview Geoffrey Young, MD, from the Association of American Medical Colleges and Thomas J. Nasca, MD, from the Accreditation Council for Graduate Medical Education, who discuss how they expect medical schools to respond to abusive behaviors and what resources are available to students and residents who have been abused to report those experiences without fearing retribution. Article discussed in this episode: Medical Student Mistreatment  

Interview with Douglas K. Owens, MD, MS, USPSTF Task Force member and coauthor of Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement

Medicare recently developed a star rating system to help consumers determine the quality of care delivered at various hospitals. This rating system was considered controversial by many. In this podcast we discuss the rating system with one of its critics, Karl Y. Bilimoria, MD, MS, and with Kate Goodrich, MD, the Director of the Center for Clinical Standards and Quality at Medicare. Article discussed in this episode: The New CMS Hospital Quality Star Ratings: The Stars Are Not Aligned

This Medical News podcast discusses the Human Genome Project-write with Harvard geneticist, George Church, PhD.

Interview with Ann E. Kurth, PhD, RN, MSN, MPH, Task Force member and co-author of Primary Care Interventions to Support Breastfeeding: US Preventive Services Task Force Recommendation Statement

In this episode of JAMA Professionalism: Best Practice, Edward H. Livingston, MD looks at the case of a physician requesting prescription medication from a colleague to examine professional boundaries between physicians and options for managing those boundaries. Shiphra Ginsburg, MD and Wendy Levinson, MD, authors of the related article, join Dr Livingston to discuss the best options for handling this challenging situation. Arthur S. Hengerer, MD, chair of the Federation of State Medical Boards discusses the legal and licensure ramifications of physicians prescribing for other clinicians and Kate E. Engelhardt, MD, and D. Brock Hewitt, MD, MPH, practicing physicians, relate their experience with other clinicians asking them to prescribe medications.

This Medical News podcast features a Q&A with CDC Director Tom Frieden, MD, commemorating the agency’s historic 70th anniversary. The interview was recorded on August 8th, 2016.

Interview with Pieter A. Cohen, MD, author of The Supplement Paradox: Negligible Benefits, Robust Consumption

Nearly all women experience some element of nausea and vomiting during their pregnancies. In this podcast we review the entire spectrum of disease all the way up to hyperemesis gravidarum and how to provide care for women experiencing these problems. Article discussed in this episode: Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy  

When managing septic shock, passive leg raising is the best test to determine if a patient is likely to respond to a fluid bolus, better than CVP lines or even bedside ultrasound. Dr Najib Ayas, Associate professor of Critical Care Medicine at the University of British Columbia, discusses shock management from the context of his Rational Clinical examination article in the September 27, 2016 issue of JAMA, entitled “Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids?”

Interview with Jeffrey L Saver, M.D., author of Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis

What to do when the wrong procedure is performed? In this first installment of JAMA Performance Improvement: Do No Harm we explore the options for dealing with this very difficult problem with Tami Minnier, RN, MSN, Paul Phrampus, MD, Linda Waddell, RN, MSN, and David Baker, MD, MPH, FACP. Air traffic audio courtesy of LiveATC.net, used with permission.  

Interview with John M. Jakicic, PhD, author of Effect of Wearable Technology Combined With a Lifestyle Intervention on Long-term Weight Loss: The IDEA Randomized Clinical Trial

Interview with Vivian S. Lee, MD, PhD, MBA;, author of Implementation of a Value-Driven Outcomes Program to Identify High Variability in Clinical Costs and Outcomes: Association With Reduced Cost and Improved Quality, and Michael E. Porter, PhD, author of From Volume to Value in Health Care: The Work Begins

Patrick Soon-Shiong, MD, physician-scientist and entrepreneur, talks about the National MoonShot Initiative, his MoonShot 2020 Program, as well as promising approaches in cancer immunotherapy. This podcast was originally recorded on June 3, 2016

Interview with Francisco A.R. García, MD, MPH, author of Screening for Latent Tuberculosis Infection in Adults: US Preventive Services Task Force Recommendation Statement

Interview with Joel G. Ray, MD, MSc, FRCPC, author of Association Between MRI Exposure During Pregnancy and Fetal and Childhood Outcomes

Drug prices continue to rise in the US. Many solutions have been proposed but few have been implemented. Drs. Janet Woodcock from the FDA and Aaron Kesselheim, author of The High Cost of Prescription Drugs in the United States from the Harvard Medical School discuss the role of brand name drugs and generics and how they influence the cost of pharmaceuticals. Also see The Cost of US Pharmaceutical Price Reductions: A Financial Simulation Model of R&D Decisions by Thomas A. Abbott and John A. Vernon.

Introducing a new series of JAMA articles on professionalism, discussed from the perspective of how clinicians should address challenging clinical situations and adverse events in their medical practice. In the first episode of the accompanying podcast, JAMA Professionalism: Best Practice, we interview Wendy Levinson, MD, and Jensen Yeung, MD, authors of Disclosure of Medical Error, which appeared in the August 16, 2016 issue of JAMA, as well as Thomas H. Gallagher, MD.

Interview with Dhruv S. Kazi, MD, MSc, MS, author of Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease

Edward H. Livingston, MD, discusses the British Columbia Ministry of Health’s 2015 guidelines on clinical management of opioid use disorder in adults with Keith Ahamad, MD,  Evan Wood, MD, PhD, ABIM, FRCPC, Tony L. Yaksh, PhD, and Humayun J. Chaudhry, DO, MS, MACP, FACOI. Articles and resources discussed in this episode:  Opioid Use and Addiction Microsite, Clinical Management of Opioid Use Disorder (JAMA Clinical Guidelines Synopsis), The Vancouver Opioid Use Disorder Guideline, Model Policy on DATA 2000 And Treatment of Opioid Addiction in the Medical Office  

Interview with David Grossman, MD, author of Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement

Interview with Axel Linke, MD, author of Effect of a Cerebral Protection Device on Brain Lesions Following Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis: The CLEAN-TAVI Randomized Clinical Trial

Interview with Barbara E. Murray, MD, author of Infectious Disease Expert Sees Threat From Colistin-Resistant Superbug

Interview with Michael P. Pignone, MD, MPH, author of Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement

Richard N. Rosenthal, MD discusses a randomized clinical trial demonstrating the efficacy of an implantable buprenorphine-releasing device for treating opioid use disorder.  

Interview with Dorry Segev, MD, PhD, author of HIV and Transplantation: New Reasons for HOPE

Lyme disease is very common in certain regions of the country and is caused by the spirochete Borrelia bergdorferi. Lyme disease is transmitted by tick bites and in this podcast we review the discovery of Lyme disease, its major clinical features, and how to diagnose and treat it, as told by Dr Alan Steere, Dr Lyndon Hu, and Dr Paul Auerwerter. Related article: Review of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis  

Interview with Ezekiel J. Emanuel, MD, PhD, author of Attitudes and Practices of Euthanasia and Physician-Assisted Suicide in the United States, Canada, and Europe

Persistent diarrhea is a poorly recognized syndrome in all populations that requires proper assessment and diagnosis to ensure that affected individuals receive the treatment needed to experience improvement of clinical symptoms. Listen to Drs Herbert DuPont and Annie Feagins discuss how to diagnose and treat diarrhea. Related article: Persistent Diarrhea

Interview with Jeff D. Williamson, MD, MHS, author of Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial

Howard Bauchner, MD, Editor in Chief of JAMA, interviews Simon Chapman, MD, author of Association Between Gun Law Reforms and Intentional Firearm Deaths in Australia, 1979-2013

Interview with Douglas K. Owens, MD, MS, author of Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement

Dr Allen Steere discovered Lyme disease and discusses what he saw and did when confronted early in his career with a previously undescribed disease. Late stage disease, a form not commonly seen today, is discussed in detail since that is how the disease presented before its cause was determined. Related article: Review of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis  

Interview with Ann E. Kurth, PhD, RN, MSN, MPH, author of Screening for Syphilis Infection in Nonpregnant Adults and Adolescents: US Preventive Services Task Force Recommendation Statement

Interview with Cynthia L. Ogden, PhD, author of Trends in Obesity Among Adults in the United States, 2005 to 2014

Interview with Gillian L. Booth, MD, author of Association of Neighborhood Walkability With Change in Overweight, Obesity, and Diabetes

Drs Stuart Spechler and Peter Kahrilis discuss GERD and esophagitis--how they occur and how they are treated. Dr Spechler also discusses a new hypothesis regarding how reflux esophagitis is caused that differs from the traditional teaching that acid and pepsin reflux into the esophagus and burn the mucosa layers. Related articles: Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes Turning the Pathogenesis of Acute Peptic Esophagitis Inside Out

Interview with Douglas B. White, MD, MAS, author of Prevalence of and Factors Related to Discordance About Prognosis Between Physicians and Surrogate Decision Makers of Critically Ill Patients

Attention-Deficit/Hyperactivity Disorder, or ADHD is a very common problem affecting about 10% of all adolescents. Children with ADHD have short attention spans, are hyperactive, talk a great deal, can be disruptive in the classroom etc.-features that are common in many adolescents. However, to have true ADHD, children must be significantly impaired by these problems. An array of medical and behavioral treatments can successfully help manage ADHD. These are reviewed in a series of articles appearing in the May 10, 2016, issue of JAMA. In this podcast, we discuss ADHD with the authors of some of those papers, Eugenia Chan, MD, MPH from Harvard and Philip Shaw, MD, PhD from the National Human Genome Research Institute. Articles discussed in this episode: Treatment of Attention-Deficit/Hyperactivity Disorder in Adolescents: A Systematic Review Quantifying the Benefits and Risks of Methylphenidate as Treatment for Childhood Attention-Deficit/Hyperactivity Disorder Methylphenidate for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents  

Interview with Pascal Hammel, MD, author of Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib: The LAP07 Randomized Clinical Trial

Christine Curry, MD, PhD, assistant professor of obstetrics and gynecology at the University of Miami, discusses the challenges of keeping pregnant patients and her colleagues well-informed of the facts as Zika virus fears circulate.

Interview with Linden Hu, MD, author of Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review

Interview with Céline Vetter, PhD, author of Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women

Interview with Antoni Ribas, MD, PhD, author of Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

Mononucleosis is a common disease of young adults manifested by lethargy, fever, pharyngitis, lymphadenopathy and splenomegaly. In this podcast, we review the clinical features of the disease and how good each of them is at establishing a diagnosis of mononucleosis. We also review how Epstein Barr virus was discovered as the cause of mononucleosis and talk to Mark H. Ebell, MD, MS, author of Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review. Articles discussed in this episode: Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review (2016) Acute Lymphatic Leukemia and Infectious Mononucleosis (1931) Infectious Mononucleosis: Part I. Clinical Aspects (1935)  Infectious Mononucleosis: Clinical Manifestations in Relation to EB Virus Antibodies (1968)

Interview with Kiros Berhane, PhD, author of Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012

Interview with Raj Chetty, PhD, author of The Association Between Income and Life Expectancy in the United States, 2001-2014, and Angus Deaton, PhD, author of On Death and Money: History, Facts, and Explanations

Interview with William R. Phillips, MD, MPH, author of Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Recommendation Statement

Interview with Wendy C. King, PhD, author of Change in Pain and Physical Function Following Bariatric Surgery for Severe Obesity

Interview with Daniel C. Cherkin, PhD, author of Effect of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care on Back Pain and Functional Limitations in Adults With Chronic Low Back Pain: A Randomized Clinical Trial

An opioid abuse epidemic now plagues US healthcare. It was caused, in part, by overzealous advocacy for controlling chronic pain resulting in overuse of narcotics. There are now 2 million Americans addicted to opioids. The approach for treating chronic pain must change. In this podcast, we summarize recent CDC guidelines for the proper use of opioids for treating chronic pain. Articles discussed in this episode: CDC Guideline for Prescribing Opioids for Chronic Pain— United States, 2016, The CDC Guideline on Opioid Prescribing: Rising to the Challenge (Yngvild Olsen, MD, MPH), The DSM-V definition for opioid use disorder and 11 point checklist

Interview with Saad B. Omer, MBBS, MPH, PhD, author of Association Between Vaccine Refusal and Vaccine-Preventable Diseases in the United States A Review of Measles and Pertussis

Polypharmacy is a rapidly worsening problem that hits elderly patients particularly hard.  As patients grow older, they need more medications but at the same time become less capable of managing the complexity of drug treatments.  In order to simplify treatment regimens for older patients, it is necessary to consider the evidence supporting treatment of various conditions and when the evidence is not particularly strong, reduce or eliminate medications accordingly.  Diabetes management in the elderly is highlighted in this podcast with specific attention given to deintensifying diabetes treatment in the elderly. Articles discussed in this episode: Polypharmacy in the Aging Patient: Glycemic Control in Older Adults With Type 2 Diabetes: A Review (Kasia J. Lipska, MD, MHS) Evaluation and Treatment of Older Patients With Hypercholesterolemia: A Clinical Review (Timo E. Strandberg, MD, PhD) Trends in Prescription Drug Use Among Adults in the United States From 1999-2012 (Elizabeth D. Kantor, PhD, MPH)

Interview with Lynn Babcock, MD, MS, author of Identifying Children and Adolescents at Risk for Persistent Postconcussion Symptoms

Interview with Michael P. Pignone, MD, MPH, author of Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement

Robert O. Bonow, MD, the editor-in-chief of JAMA Cardiology, the JAMA Network’s newest addition, discusses his editorial vision for the journal, as well as his insights on advances in the prevention and treatment of cardiovascular disease.  

Interview with Clifford Deutschman, MD, MS, Mervyn Singer, MD and Derek Angus, MD, MPH, authors of The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Interview with John G. Laffey, MD, MA, author of Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

Interview with David C. Grossman, MD, MPH, author of Screening for Autism Spectrum Disorder in Young Children: US Preventive Services Task Force Recommendation Statement

Community acquired pneumonia accounts for 600,000 hospital admissions a year. Many patients with this disease are quite ill and have a very high mortality. To save lives, the appropriate antibiotics should be given in a timely basis, but it is not clear what the best antibiotics are and how long they should be given. In this podcast we interview the author of a JAMA review on community acquired pneumonia, Dr Jonathan Lee, author of Antibiotic Therapy for Adults Hospitalized With Community-Acquired Pneumonia, who performed a systematic review of the literature to determine the best way to treat community acquired pneumonia.

The 2015-2020 US Dietary Guidelines for Americans were recently released. They are intended to provide guidance for health policy officials and clinicians regarding healthy diets and establishing goals for improving nutrition. These are important since bad eating habits are the underlying cause for a great deal of disease in the US and that these guidelines influence the operations of programs such as school lunch assistance, meals on wheels etc. Because these guidelines influence policy, they have been criticized by various investigators and special interest groups. Karen DeSalvo, MD, Acting Assistant Secretary for Health at HHS and author of Dietary Guidelines for Americans responds to some of these criticisms and explains how the guideline was created and what it is intended to do. Implementation of the guidelines dietary advice may be challenging and Deborah Clegg, RD, PhD, Professor of Internal Medicine at UCLA discusses how the various recommendations can be followed.

Interview with Martha Clare Morris, ScD, author of Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

Interview with Michael P. Pignone, MD, MPH, author of Screening for Depression in Adults: US Preventive Services Task Force Recommendation Statement

Peripheral neuropathy is a highly prevalent and morbid condition affecting 2% to 7% of the population. Patients frequently experience pain and are at risk of falls, ulcerations, and amputations. It is most commonly occurs in patients with diabetes. For most cases, the diagnosis and treatment of neuropathy can be made without complex testing or referral to specialists. Drs. Eva Feldman and Brian Callaghan from the University of Michigan Department of Neurology, authors of Distal Symmetric Polyneuropathy and Electrodiagnostic Tests in Polyneuropathy and Radiculopathy, explain how to manage neuropathy.

Interview with Justin E. Bekelman, MD, author of Comparison of Site of Death, Health Care Utilization, and Hospital Expenditures for Patients Dying With Cancer in 7 Developed Countries

Constipation is one of the most frequent problems clinicians are asked to deal with. Despite how common it is, constipation is frequently not treated adequately. In this podcast, Arnold Wald, MD, explains a stepwise approach to the management of constipation ranging from very simple measures to the most novel and complicated new medical therapies.

Interview with Gaëtan Deslée, MD, PhD, author of Lung Volume Reduction Coil Treatment vs Usual Care in Patients With Severe Emphysema: The REVOLENS Randomized Clinical Trial

Interview with Karen DeSalvo, MD, MPH, MSc, author of Dietary Guidelines for Americans

Interview with Dalane W. Kitzman, MD, author of Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Minor head trauma usually does not cause significant brain injury. To be safe, clinicians often obtain head CT scans to ensure no major injury is present. For minor head trauma (Glascow coma scale 13-15), the risk to benefit ratio for head CT is usually not in favor of getting CT scans. When the Canadian head CT rule or New Orleans Criteria are negative, there is a very small risk for missing a significant brain injury. Joshua Easter, MD from the Department of Emergency Medicine at the University of Virginia who authored a JAMA Rational Clinical Examination article on this topic is interviewed as is Frederick Rivara, from the Department of Pediatrics at the University of Washington who wrote an accompanying editorial. Michelle Mello, a Law Professor at Stanford, discusses the medical liability associated with not obtaining neuroimaging for minor head trauma.

Interview with Debbie A. Lawlor, PhD, author of Live-Birth Rate Associated With Repeat In Vitro Fertilization Treatment Cycles

Edward H. Livingston, MD discusses Graves disease with David Cooper, MD, author of Management of Graves Disease: A Review

Interview with John H. Sampson, MD, PhD, MHSc, MBA, author of Alternating Electric Fields for the Treatment of Glioblastoma

Interview with Roger Stupp, MD, author of Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial

Interview with Thomas L. Schwenk, MD, author of Resident Depression: The Tip of a Graduate Medical Education Iceberg

Interview with Ingrid M. Libman, MD, PhD, author of Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes

Interview with Alex B. Haynes, MD, MPH, author of Relationship Between Cesarean Delivery Rate and Maternal and Neonatal Mortality

Edward H. Livingston MD, explores the topic of prostate cancer screening in author interviews with: Dan Merenstein about losing a malpractice case despite following evidence-based medicine guidelines (PSA Screening — I Finally Won!). Otis Brawley about Prostate Cancer Incidence and PSA Testing Patterns in Relation to USPSTF Screening Recommendations. David F. Penson about The Pendulum of Prostate Cancer Screening. Victor M. Montori about The Connection Between Evidence-Based Medicine and Shared Decision Making.

Edward H. Livingston, MD, Deputy Editor of Clinical Reviews and Education discusses prostate cancer screening with Otis Brawley, MD, author of Prostate Cancer Incidence and PSA Testing Patterns in Relation to USPSTF Screening Recommendations and David F. Penson, MD, MPH, author of a related editorial entitled The Pendulum of Prostate Cancer Screening.

Edward H. Livingston, MD, Deputy Editor of Clinical Reviews and Education and Jon Tilburt, MD, from the Mayo Clinic explain prostate cancer screening. For more information, read the JAMA Patient Page on this topic.

Interview with Leonard B. Bacharier, MD, author of Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial

Interview with Lee M. Jampol, MD, author of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial

ACS is a common and potentially lethal problem. However, only about 10% of patients who present to an emergency department with chest pain actually have ACS. In this JAMA Clinical Reviews podcast, we discuss which signs, symptoms and tests used to make the diagnosis of ACS are reliable. Edward H. Livingston MD, speaks with Alexander Fanaroff, MD, author of Does This Patient With Chest Pain Have Acute Coronary Syndrome? The Rational Clinical Examination Systematic Review as well as a patient who was diagnosed with myocardial infarction.

Interview with David Simel, MD, author of Does This Patient With Chest Pain Have Acute Coronary Syndrome? The Rational Clinical Examination Systematic Review

Interview with David A. Asch, MD and Kevin G. Volpp, MD, PhD, authors of Effect of Financial Incentives to Physicians, Patients, or Both on Lipid Levels: A Randomized Clinical Trial

Interview with Elizabeth D. Kantor, PhD, MPH, author of Trends in Prescription Drug Use Among Adults in the United States From 1999-2012

Interview with Ahmedin Jemal, DVM, PhD, author of Temporal Trends in Mortality in the United States, 1969-2013, and J. Michael McGinnis, MD, MPP, author of Mortality Trends and Signs of Health Progress. Also in this episode is a conversation with Christopher J.L. Murray, MD, DPhil, a Professor of Global Health at the University of Washington and Institute Director of the Institute for Health Metrics and Evaluation.

Interview with Ahmedin Jemal, DVM, PhD, author of Temporal Trends in Mortality in the United States, 1969-2013

Interview with Elizabeth T. H. Fontham, MPH, DrPH, author of Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society, Nancy L. Keating, MD, MPH, author of New Guidelines for Breast Cancer Screening in US Women, and Evan R. Myers, MD, MPH, author of Benefits and Harms of Breast Cancer Screening: A Systematic Review

Interview with Kevin C. Oeffinger, MD, author of Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society

Interview with James Fleshman, MD, author of Effect of Laparoscopic-Assisted Resection vs Open Resection of Stage II or III Rectal Cancer on Pathologic Outcomes: The ACOSOG Z6051 Randomized Clinical Trial

Interview with Carlos G. Grijalva, MD, MPH, author of Association Between Hospitalization With Community-Acquired Laboratory-Confirmed Influenza Pneumonia and Prior Receipt of Influenza Vaccination

Interview with Timothy Fendler, MD, MS, author of Alignment of Do-Not-Resuscitate Status With Patients’ Likelihood of Favorable Neurological Survival After In-Hospital Cardiac Arrest

Interview with Jeffrey L. Cummings, MD, ScD, author of Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial

Interview with Anupam Jena, MD, PhD, author of Sex Differences in Academic Rank in US Medical Schools in 2014

Adi Nadimpalli, MD, the Doctors Without Borders/Médecins Sans Frontières (MSF) Head of Mission in Nepal, and the former vice president of the US board of directors, talks about MSF’s mission and the challenges he has faced serving in countries where access to health care is insufficient or strained due to natural or manmade disasters, violent conflicts, epidemics, and population displacement.

Interview with Andy Menke, PhD, author of Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012

Interview with Luke Rudmik, MD, MSc, author of Medical Therapies for Adult Chronic Sinusitis: A Systematic Review. This systematic review summarizes the evidence-based medical treatment of adult chronic sinusitis and proposes a treatment algorithm.

Interview with Bridget A. Fernandez, MD, author of Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder

Interview with Timothy Ley, MD, author of Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

Interview with Kaycee M. Sink, MD, MAS, author of Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial

Interview with Nancy A. Rigotti, MD, author of e-Cigarette Use and Subsequent Tobacco Use by Adolescents: New Evidence About a Potential Risk of e-Cigarettes

Interview with Adam M. Leventhal, PhD, author of Association of Electronic Cigarette Use With Initiation of Combustible Tobacco Product Smoking in Early Adolescence

Interview with Rachel E. Patzer, PhD, MPH, author of Variation in Dialysis Facility Referral for Kidney Transplantation Among Patients With End-Stage Renal Disease in Georgia. This population epidemiology study uses United States Renal Data System data to characterize dialysis facility–level referral for kidney transplant evaluation in Georgia, the US state with the lowest transplantation rates, and patient and facility factors associated with referral and waitlisting.

Interview with Shalender Bhasin, MBBS, author of Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial

Edward H. Livingston, MD, interviews a war veteran and discusses PTSD with Maria Steenkamp, PhD, author of Psychotherapy for Military-Related PTSD, and Michele Spoont, PhD, author of Rational Clinical Exam: Does This Patient Have Posttraumatic Stress Disorder? The article by Dr Steenkamp reports that many military personnel and veterans with posttraumatic stress disorder achieve clinically meaningful improvement with use of the first-line trauma-focused interventions cognitive processing therapy and prolonged exposure.
 The Rational Clinical Examination Systematic Review by Dr Spoont examines the utility of self-report screening instruments for posttraumatic stress disorder among primary care and high-risk populations.

Interview with Melissa A. Polusny, PhD, author of Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial

Interview with Drew Altman, PhD and William Frist, MD, authors of Medicare and Medicaid at 50 Years: Perspectives of Beneficiaries, Health Care Professionals and Institutions, and Policy Makers

Medicare at 50: Reflections From Former CMS Administrator Donald M. Berwick, MD

Interview with Harlan M. Krumholz, MD, SM, author of Mortality, Hospitalizations, and Expenditures for the Medicare Population Aged 65 Years or Older, 1999-2013

Edward H. Livingston, MD discusses atrial fibrillation with Eric N. Prystowsky, MD, author of Treatment of Atrial Fibrillation. This review article reports that therapy for atrial fibrillation should include rate control for all patients, but maintenance of sinus rhythm with drugs or catheter ablation should be considered on an individual patient basis. Also on the program is a conversation about new technologies to facilitate screening for atrial fibrillation with Leslie Saxon, MD.

Interview with Carolina Malta Hansen, MD, author of Association of Bystander and First-Responder Intervention With Survival After Out-of-Hospital Cardiac Arrest in North Carolina, 2010-2013

Interview with Thomas A. Gaziano, MD, MSc, author of Cost-effectiveness of 10-Year Risk Thresholds for Initiation of Statin Therapy for Primary Prevention of Cardiovascular Disease

Interview with Diana W. Bianchi, MD, author of Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies

Interview with Francis Couturaud, MD, PhD, author of Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial

Interview with Deborah A. Levine, MD, MPH, author of Trajectory of Cognitive Decline After Incident Stroke

Harold Varmus, MD, former director of the National Cancer Institute, talks about his career and his ideas for improving the biomedical research enterprise.

Interview with Kevin P. Hill, MD, MHS, author of Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review, and Deepak Cyril D'Souza, MBBS, MD, author of Medical Marijuana: Is the Cart Before the Horse?

Interview with Tracy Y. Wang, MD, MHS, MSc, author of Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Acute Myocardial Infarction

JAMA Topic Review: Edward Livingston, MD, FACS, AGAF, Deputy Editor of JAMA, explores how the study by Paulina Salminen, MD, PhD, supports treating appendicitis without surgery

Interview with Chyke A. Doubeni, MD, MPH, author of Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model

Interview with Ellen Wright Clayton, MD, JD , author of Why the Americans With Disabilities Act Matters for Genetics

Interview with Eve Hill, JD, author of The ADA, Disability, and Identity

Interview with Samuel R. Bagenstos, JD, author of The ADA and the Supreme Court: A Mixed Record

Interview with Levi J. Hargrove, PhD, author of Intuitive Control of a Powered Prosthetic Leg During Ambulation: A Randomized Clinical Trial

Interview with Patrick H. Conway, MD, MSc, author of Association of Pioneer Accountable Care Organizations vs Traditional Medicare Fee for Service With Spending, Utilization, and Patient Experience

Interview with Krista F. Huybrechts, MS, PhD, author of Antidepressant Use Late in Pregnancy and Risk of Persistent Pulmonary Hypertension of the Newborn

Interview with Anne R. Cappola, MD, ScM, author of Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis

Interview with Harley Goldberg, DO, author of Oral Steroids for Acute Radiculopathy Due to a Herniated Lumbar Disk: A Randomized Clinical Trial

Interview with Andrew J. Muir, MD, author of Daclatasvir in Combination With Asunaprevir and Beclabuvir for Hepatitis C Virus Genotype 1 Infection With Compensated Cirrhosis

Interview with Dale N. Gerding, MD, author of Administration of Spores of Nontoxigenic Clostridium difficile Strain M3 for Prevention of Recurrent C difficile Infection: A Randomized Clinical Trial

Interview with Gail D'Onofrio, MD, MS, author of Emergency Department-Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial

Interview with Ezio Bonifacio, PhD, author of Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes: The Pre-POINT Randomized Clinical Trial

Interview with Anjali Jain, MD, author of Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

Interview with Anny H. Xiang, PhD, author of Association of Maternal Diabetes With Autism in Offspring

Interview with Justin B. Dimick, MD, MPH, author of Hospital Credentialing and Privileging of Surgeons: A Potential Safety Blind Spot

Interview with Mark J. Mulligan, MD, author of Emergency Postexposure Vaccination With Vesicular Stomatitis Virus-Vectored Ebola Vaccine After Needlestick

Interview with Jeffrey G. Jarvik, MD, MPH, author of Association of Early Imaging for Back Pain With Clinical Outcomes in Older Adults

Interview with Joann G. Elmore, MD, MPH, author of Diagnostic Concordance Among Pathologists Interpreting Breast Biopsy Specimens

Interview with Xiaobin Wang, MD, ScD, author of Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China: The CSPPT Randomized Clinical Trial

Interview with David R. Holmes Jr, MD, author of Clinical Outcomes at 1 Year Following Transcatheter Aortic Valve Replacement

Interview with Sebastiano Filetti, MD, author of The Natural History of Benign Thyroid Nodules

Interview with Vicky Stergiopoulos, MD, author of Effect of Scattered-Site Housing Using Rent Supplements and Intensive Case Management on Housing Stability Among Homeless Adults With Mental Illness

Interview with William E. Evans, PharmD, author of Association of an Inherited Genetic Variant With Vincristine-Related Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia

Interview with Antoni Torres, MD, PhD, author of Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response: A Randomized Clinical Trial

Interview with Jon O. Ebbert, MD, MSc, author of Effect of Varenicline on Smoking Cessation Through Smoking Reduction

Interview with Joseph E. Kiss, MD, author of Oral Iron Supplementation After Blood Donation

Interview with Donald M. Berwick, MD, MPP, author of Measuring Surgical Outcomes for Improvement: Was Codman Wrong?

Interview with Karl Y. Bilimoria, MD, MS, author of Underlying Reasons Associated With Hospital Readmission Following Surgery in the United States

Interview with Peter A. Pinto, MD, author of Comparison of MR/Ultrasound Fusion-Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer

Interview with Richard K. Burt, MD, author of Association of Nonmyeloablative Hematopoietic Stem Cell Transplantation With Neurological Disability in Patients With Relapsing-Remitting Multiple Sclerosis

Interview with Sheree L. Boulet, DrPH, MPH, author of Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection

Interview with Steven A. Narod, MD, FRCPC, author of Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States

Interview with David E. Arterburn, MD, MPH and Matthew L. Maciejewski, PhD, authors of Association Between Bariatric Surgery and Long-term Survival

Interview with David M. Nathan, MD, author of Association Between 7 Years of Intensive Treatment of Type 1 Diabetes and Long-term Mortality

Interview with Seetha Shankaran, MD, author of Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial

Tom Frieden, MD, MPH, Director, Centers for Disease Control and Prevention, talks with Howard Bauchner, MD, Editor in Chief of JAMA, about the Ebola crisis and the CDC’s response (originally posted on 10-23-2014).

Dr Aiah A. Gbakima, editor in chief of the Sierra Leone Journal of Biomedical Research, talks about confronting the Ebola outbreak in Sierra Leone (originally posted on 10-2-2014).

Interview with Ricardo A. Mosquera, MD, author of Effect of an Enhanced Medical Home on Serious Illness and Cost of Care Among High-Risk Children With Chronic Illness

Interview with Frank M. Sacks, MD, author of Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity

Interview with Bradley M. Gray, PhD, author of Association Between Imposition of a Maintenance of Certification Requirement and Ambulatory Care-Sensitive Hospitalizations and Health Care Costs

Interview with Mitesh S. Patel, MD, MBA, MS, author of Association of the 2011 ACGME Resident Duty Hour Reforms With Mortality and Readmissions Among Hospitalized Medicare Patients

Interview with Joseph B. Muhlestein, MD, author of Effect of Screening for Coronary Artery Disease Using CT Angiography on Mortality and Cardiac Events in High-Risk Patients With Diabetes

Interview with Michelle M. Mello, JD, PhD, MPhil, author of The Medical Liability Climate and Prospects for Reform

Interview with Arthur J. Reynolds, PhD, author of Association of a Full-Day vs Part-Day Preschool Intervention With School Readiness, Attendance, and Parent Involvement

Interview with Stefanie Schulz-Schüpke, MD, author of Comparison of Vascular Closure Devices vs Manual Compression After Femoral Artery Puncture: The ISAR-CLOSURE Randomized Clinical Trial

Interview with George A. Stouffer, MD, author of Association of Inpatient vs Outpatient Onset of ST-Elevation Myocardial Infarction With Treatment and Clinical Outcomes

Interview with Ziad Obermeyer, MD, MPhil, author of Association Between the Medicare Hospice Benefit and Health Care Utilization and Costs for Patients With Poor-Prognosis Cancer

Interview with Ilan Youngster, MD, MMSc, author of Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection

Interview with Thomas M. Maddox, MD, MSc, author of Nonobstructive Coronary Artery Disease and Risk of Myocardial Infarction

Interview with Ashish K. Jha, MD, MPH, author of Association Between Hospital Conversions to For-Profit Status and Clinical and Economic Outcomes

Interview with Jonathan A. Patz, MD, MPH, author of Climate Change: Challenges and Opportunities for Global Health

Interview with Elizabeth A Howell, MD, MPP, author of Durability of Benefits of an Outpatient Antimicrobial Stewardship Intervention After Discontinuation of Audit and Feedback

Interview with Shelley S. Magill, MD, PhD, author of Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011

Interview with Kim L. Bennell, PhD, author of Acupuncture for Chronic Knee Pain: A Randomized Clinical Trial

Interview with Irfan A. Dhalla, MD, MSc, author of Effect of a Postdischarge Virtual Ward on Readmission or Death for High-Risk Patients

Interview with Miriam Kuppermann, PhD, MPH, author of Effect of Enhanced Information, Values Clarification, and Removal of Financial Barriers on Use of Prenatal Genetic Testing

Interview with Marc Carrier, MD, MSc, author of Clinical and Safety Outcomes Associated With Treatment of Acute Venous Thromboembolism: A Systematic Review and Meta-analysis

Interview with Andrea S. Gershon, MD, MSc, author of Combination Long-Acting β-Agonists and Inhaled Corticosteroids Compared With Long-Acting β-Agonists Alone in Older Adults With Chronic Obstructive Pulmonary Disease

Interview with George R. Buchanan, MD, author of Management of Sickle Cell Disease

Interview with Bradley C. Johnston, PhD, author of Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults: A Meta-analysis

Interview with Allison W. Kurian, MD, MSc, author of Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011

Interview with Laura P. Richardson, MD, MPH, author of Collaborative Care for Adolescents With Depression in Primary Care

Interview with Harsha Thirumurthy, PhD, author of Effect of Providing Conditional Economic Compensation on Uptake of Voluntary Medical Male Circumcision in Kenya: A Randomized Clinical Trial

Interview with Nancy A. Rigotti, MD, author of Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults

Interview with Hooman Kamel, MD, author of Perioperative Atrial Fibrillation and the Long-term Risk of Ischemic Stroke

Interview with Karen A. D'Silva, MD, MS, author of Does This Man With Lower Urinary Tract Symptoms Have Bladder Outlet Obstruction? The Rational Clinical Examination: A Systematic Review

Interview with Richard Saitz, MD, MPH, author of Screening and Brief Intervention for Drug Use in Primary Care

Interview with Mark S. Sulkowski, MD, author of Sofosbuvir and Ribavirin for Hepatitis C in Patients With HIV Coinfection

Interview with Mads E. Jørgensen, MB, author of Time Elapsed After Ischemic Stroke and Risk of Adverse Cardiovascular Events and Mortality Following Elective Noncardiac Surgery

Interview with Kurt Kroenke, MD, author of Telecare Collaborative Management of Chronic Pain in Primary Care

Interview with Danny Dvir, MD, author of Transcatheter Aortic Valve Implantation in Failed Bioprosthetic Surgical Valves

Interview with Claudia S. Robertson, MD, author of Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury: A Randomized Clinical Trial

Interview with John F. Tisdale, MD, author of Nonmyeloablative HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Phenotype

Interview with Sarah M. Friedewald, MD, author of Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography

Interview with Nynne Nyboe Andersen, MD, author of Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Interview with Christianne L. Roumie, MD, MPH, author of Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes

Interview with Rupert M. Pearse, MD, author of Effect of a Perioperative, Cardiac Output-Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review

Interview with Eric M. Mortensen, MD, MSc, author of Association of Azithromycin With Mortality and Cardiovascular Events Among Older Patients Hospitalized With Pneumonia

Interview with Marco Pahor, MD, author of Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial

Interview with Kim L. Bennell, PhD, author of Effect of Physical Therapy on Pain and Function in Patients With Hip Osteoarthritis: A Randomized Clinical Trial

Interview with Mark G. Kris, MD, author of Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Interview with Mario Castro, MD, author of Effect of Vitamin D3 on Asthma Treatment Failures in Adults With Symptomatic Asthma and Lower Vitamin D Levels

Interview with Larry Wolk, MD, MSPH, chief medical officer for the Colorado Department of Public Health, about medical and legalized marijuana in Colorado.

Interview with Robert N. Weinreb, MD, author of The Pathophysiology and Treatment of Glaucoma

Interview with Sven Sandin, MSc, author of The Familial Risk of Autism

Interview with Dana Dabelea, MD, PhD, author of Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

Interview with Gregg C. Fonarow, MD, author of Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

Interview with Mohamed Abdel-Wahab, MD, author of Comparison of Balloon-Expandable vs Self-expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement: The CHOICE Randomized Clinical Trial

Interview with Daniel J. Clauw, MD, author of Fibromyalgia: A Clinical Review

Interview with Louise C. Walter, MD and Mara A. Schonberg, MD, MPH, authors of Screening Mammography in Older Women: A Review

Interview with Nancy L. Keating, MD, MPH, author of A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions

Interview with Ann Marie Navar-Boggan, MD, PhD, author of Proportion of US Adults Potentially Affected by the 2014 Hypertension Guideline

Interview with Henry Waxman (D, Calif) who is retiring from Congress after 20 terms.

Interview with Nicholas J. Horton, ScD, author of Web-Based Alcohol Screening and Brief Intervention for University Students: A Randomized Trial

Interview with Michael J. Barry, MD, author of Screening for Prostate Cancer With the Prostate-Specific Antigen Test: A Review of Current Evidence

Interview with Derek C. Angus, MD, MPH, author of Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation

Interview with Matthew D. Barber, MD, MHS, author of Comparison of 2 Transvaginal Surgical Approaches and Perioperative Behavioral Therapy for Apical Vaginal Prolapse

Interview with Juan Jesús Carrero, PhD(Pharm and Med), author of Warfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients With Atrial Fibrillation

Interview with Ronald C. Kessler, PhD, author of Associations of Housing Mobility Interventions for Children in High-Poverty Neighborhoods With Subsequent Mental Disorders During Adolescence

Interview with Mark W. Friedberg, MD, MPP, author of Association Between Participation in a Multipayer Medical Home Intervention and Changes in Quality, Utilization, and Costs of Care

Interview with Claudia A. Steiner, MD, MPH, author of Surgical Site Infections Following Ambulatory Surgery Procedures

Interview with Constantine G. Lyketsos, MD, MHS, author of Effect of Citalopram on Agitation in Alzheimer Disease

Interview with Lisen Arnheim-Dahlström, PhD, author of Association of Varying Number of Doses of Quadrivalent Human Papillomavirus Vaccine With Incidence of Condyloma

Interview with Troyen A. Brennan, MD, MPH, author of Ending Sales of Tobacco Products in Pharmacies

Interview with Norrina B. Allen, PhD, MPH, author of Blood Pressure Trajectories in Early Adulthood and Subclinical Atherosclerosis in Middle Age

Interview with Joseph S. Ross, MD, MHS, author of Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012

Interview with John N. Primrose, MD, FRCS, author of Effect of 3 to 5 Years of Scheduled CEA and CT Follow-up to Detect Recurrence of Colorectal Cancer: The FACS Randomized Clinical Trial

Interview with Michael H. Criqui, MD, MPH, author of Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events