Our guest for the week is Hyla Cass, an integrative psychiatrist practiced in the field even before the term was coined. Her 25-year long practice is marked by the non-drug, natural system boosting approach, which landed her the nation-wide acclaim along with numerous awards. She is here to talk to us about the subversive effects of medications, the systems approach to medicine, as well as about enhancing our cognitive performance. Side-effect Are Still Effects Stuffing oneself with medication rarely comes without the so-called side-effects. What is important to realize, however, is that the ‘side-effects’ are actually the ‘effects’ of a medication; they are a part of the whole bodily response to, or indeed against, that medication. The purple pill for instance, one of the proton-pump inhibitors, is a fairly available drug that may, in a long run, because the system adjusts and later craves for its usage, cause many hitherto unforeseen and avoidable microbiome problems. Therefore, Instead of forcing the system and suppressing it into an unnatural submission, much more profound effects can be achieved by letting the brain and body work out the problem by themselves. “the medications upset homeostasis of the brain and can cause more problems than they solve”  Take a Pill VS. The Systems Approach Medications are not necessarily bad, but overprescribing them certainly is. Write off a patient with a simple prescription has become the expected doctoral practice nowadays. Much better than the simple pill approach is to, when treating a person, take the whole system into account and boost is. Taking both internal and external factors into consideration, the systems approach goal is to give the body the best possible chance to overcome an issue by itself, mobilizing its own natural resources. Take trauma for instance; any trauma related disorder can be likened to a program that runs in the back of one’s mind, essentially affecting everything. Taking a pill would solve nothing; we need to clear up the underlying program first before treating an issue.    “We need to respect what the individual biochemistry is doing @hylacassmd” Endless Charts and Diagrams Today’s medicine falls into a trap of overcharting the treatment process, neglecting the individuality of each case. Everything is subdued to sort of a medicinal syllogism; a symptom is always followed by a prescribed treatment route which in effect negates the fact that every case is, just as people are, different. The situation is not all that new, it became effective with the branching specialization of medicine, and can be solved by, while of course keeping the specialist medicine, returning to a more holistic approach to treatment. Empowering Your Brain Another field of practice for Dr. Cass that perfectly fits into the systems approach is the cognitive function enhancement. Being the best possible version of ourselves is best achieved through slight, or not so slight lifestyle modifications. Sleep is one factor, diet or exercise another. The exposure to toxins, and the genetic predisposition thereof, may also play a crucial role concerning the quality of life. Resource Links Dr. Hyla Cass’ Website Supplement Your Prescription: What Your Doctor Doesn’t Know About Nutrition Reclaim Your Brain Free Ebook Dr. Cass’s Articles

Our guest for the week is Dr. Lucia Aronica, a postdoctoral fellow at Stanford Cancer Center and an expert on epigenetic medicine. Her main focus revolves around genomics of nutrition, that is, the correlation between diet and the changes in epigenetic landscape. Holding a Ph.D. in Molecular Biology, Dr. Aronica has spent the last decade researching the influence lifestyle has on our genomes. Her endeavors landed her not just a few recognitions, Marie Curie Global Fellowship Award being one of them. In this interview, she shares her thoughts on food, diet, as well as sheds some light on the role epigenetics plays in weight loss. Not All Food Should be Counted as Such Coming from Italy, pasta and bread were an inseparable part of Dr. Aronica’s early life. But Mediterranean diet, hailed as it is, accounts for much more that the iconic, yet not so healthy duo. This diet holds precedence over typical ‘western’ diets mainly because of the olive oil, which pitted against omega 3 seed oils, strikes a dashing victory in terms of weight and triglycerides loss. The concept of food is also differently conceived in the Mediterranean diet. The quick fixes are not counted as food in Italy, nor should anywhere else: one has to find the time for some cooking. Nature and Nurture Working Together The single best way to attain nutritional health is to strike a steady and sustainable balance. Genetics does play a role and, to an extent, predestine the type of diet a person needs. But, it would be false to assume that our lifestyles do not play their role, for it is they that influence the epigenetic image in our cells. The combination of genetics and lifestyle make each of us different and nutritionally unique. Still, there are a few universals, one of which marks a respective correlation between the decrease in carbohydrates and the decrease of triglycerides. The latter in turn has an effect on cardiovascular risks and the amount of bad cholesterol that strikes the arteries. Lowering the carbs, therefore, plays the role in reducing the risk of atherosclerosis. The Stanford Studies Dr. Aronica is currently playing a role in one of the largest studies concerning weight loss. It is a follow-up to an earlier, Stanford A to Z study, where more than 300 women were subjected to four popular diets, (Atkins, Zone, LEARN, and Ornish) measuring their results after one year. At the surprise of many, the very low-carb Atkins diet came out on top in terms of weight loss, cholesterol, and blood pressure. The new study will be bigger, include both men and women, and explore more thorough results like micro-biome and body composition change, as well as the changes in epigenetic landscape.  Epigenetics as a Growing Discipline Gastric bypass patients yielded significant knowledge regarding the epigenetic research. The different epigenetic image and the weight-loss they experienced after the operation proved that the epigenetic markers are potentially reversible, in this case from ones found in obese to those seen in lean people. These markers may also be transmissible to future generations, but further study is needed to see whether sperm incorporates these epigenetic changes. Epigenetics is a growing branch of medicinal science, today even able to predict the risk of type-2 diabetes. But what of tomorrow? The future discoveries are imminent, due to the change in approach. Namely, instead of looking at a few genes or a few hundreds of them, epigenetic researchers, Dr. Aronica among them, are bent towards looking at the entire genome. Also, epigenetic research is determined to explore the DNA in its entirety, including the non-coding regions. It is quite a feat, but the outcomes potentially exceed the effort by a margin. Resource Links Dr. Aronica’s Stanford Research profile The Stanford A to Z study The Follow-up Study

Aaron Traywick is the founder at Ascendance Biomedical where they focus on helping people get the treatments and care they need to save their lives. They also specialize in helping fund and facilitate research by taking initial studies off shore before bringing the data back to the FDA. Learn more about this process as well as two studies they're currently working on. He shares some of the results they're seeing and potential for the industry with this particular treatment for longevity and life extension overall. Enrollment is currently open for trials to test “Bucky-balls” (also known as Fullerene-C60 and “Bucky-balls”) for their capacity to increase lifespan and maximize human performance.   Learn more about the Senolytic Treatments we talk about in the interview and sign up to join the study here Apeiron Academy educates and trains Epigenetic Human Potential Coaches in genomic precision wellness and human potential optimization. Get all the details here. Ascendance Biomed Global Healthspan Policy Institute

Daniel Schmachtenberger enlightens us on how to use a science systems approach to our health, wellness and business. Listen in on how human behavior affects the systems we function in every day - economic, social, political and how we can make these systems stronger and more resilient by changing the human body's systems.

With today's guest Nicola Pirastu we learn the difference between several common genetic terms, how your diet choices may or may not be good for your personal health and how your diet can impact your genes and their expressions. Genetics Vs Genomics The terms genetics and genomics sound alike, and they are often used interchangeably. But there are some important distinctions and similarities between genetics and genomics and how they affect our dietary patterns. But firstly, what do they mean? Genetics is the study of heredity, or how the characteristics of living organisms are transmitted from one generation to the next via DNA, and it comprises genes, the basic unit of heredity. Genetics dates back to Darwin and scientist Lamarck, whose studies of pea plants in the mid-1800s established many of the rules of heredity. Genetics involves the study of specific and limited numbers of genes, or parts of genes, that have a known function. In biomedical research, scientists try to understand how genes guide the body’s development, cause disease or affect our eating or dietary patterns. Genomics, in contrast, is the study of the entirety of an organism’s genes – called the genome. Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes. Genomics is a much newer field than genetics and became possible only in the last couple of decades due to technical advances in DNA sequencing and computational biology. (It is notable that the term genomics was first coined in 1986 by a Jackson Laboratory scientist, Tom Roderick, Ph.D.) Genomics play huge roles in our dietary patterns as they help us know why our body relates to different foods and why our food preferences may or may not affect our overall health. For example two men of the same age were placed on a diet and eat fruits and vegetables high in sodium and saturated fat. One develops hypertension, hypercholesterolemia, and eventually atherosclerosis, while the other lives a long life without such chronic disease. In another case, two postmenopausal women consume similar diets low in choline. One develops liver dysfunction due to the choline deficiency, but the other does not. Why individuals experience different health outcomes even though they eat similar diets and practice comparable lifestyles is an important question that’s been on the minds of nutrition and other healthcare experts in the medical community for decades. While it’s long been suspected that genetics plays a critical role in determining how a person responds to dietary intake, only recently has research in the field of nutrigenetics demonstrated this. Learn the difference between nutrigenetics and nutrigenomics? Nutrigenetics: This is the study of the relationship among genes, diet, and health. Nutrigenomics: This involves the study of the interaction between nutrients and genes at the molecular level. Nutrition scientists have looked at whether genetic testing ends up improving eating behaviors. The evidence is mixed. A recent large randomized controlled study found there was little apparent benefit. The two weeks study comprised of 200 people. Three groups of participants were given personalized dietary advice, with variations based on their regular diet, including blood biomarkers such as cholesterol; and genetic variants. A control group was given conventional dietary advice. At the end of the study, the three groups that received personalized nutrition advice had all improved their eating habits, compared with the control group. But the improvements in each of the three groups were about the same. “It didn’t seem to matter whether they were personalized based on current diet. Nutrigenetics and Personalized Nutrition The field of nutrigenetics is relatively new. In 2003, the Human Genome Project, which identified all the genes in human DNA and determined the sequence of the 3 billion chemical base pairs that make up human DNA, was completed. Knowing the sequences of the human genome opened the doors to examine the relationship among an individual’s genetic makeup, dietary intake, and health outcomes. The excitement surrounding nutrigenetics stems from the notion that it’s the foundation of personalized nutrition. Clearly, population-based dietary recommendations are helpful, but they aren’t adequate for all individuals since people respond differently to diets. Personalized nutrition bases dietary recommendations on genetic predisposition to disease. The idea is that once personalized nutrition is integrated into routine care, patients can be genotyped for specific genetic variations, made aware of their nutrient deficiencies, and given strategies to dramatically reduce their risk. Effects of Genomic Research Genome-based research is already enabling medical researchers to develop improved diagnostics, more effective therapeutic strategies, evidence-based approaches for demonstrating clinical efficacy, and better decision-making tools for patients and providers. Ultimately, it appears inevitable that treatments will be tailored to a patient's particular genomic makeup. Thus, the role of genetics in health care is starting to change profoundly and the first examples of the era of genomic medicine are upon us. You can have a healthy diet not because it’s good but because it’s healthy. Join the LIVE Webinar Ability to losing weight, insulin resistance, how to assess your own genomic information for what diet will work best for you. When: December 8th @ 7:30PM  Free Consultation Call With Dr. Dan Stickler Mention this podcast episode in your contact form before your free consultation!

Pioneer in the world of Gene therapy, Dr. Theodore Friedman shares with us today the exciting future of what gene therapy holds. Listen in as we hear how manipulating certain lacking or misbehaving genes from causing disease has been proven in several types of diseases through clinical experimentation and how it will benefit future generations. We discuss whether or not it will be a solution to all disease. What the census is on how fast it will take or the prediction of genomic therapy within the scientific world. Gain greater awareness of gene modification within the world sport arena (Olympics), what kind of testing has been approved, used and how the tests are able to find modified genes or the presence of agents used to deliver those editing genes. What is the ethical answer of testing in sports when certain individuals naturally have genes that give increased ability to perform at a higher level than others? Applying Gene Therapy Attack of genetic disease - using your genes as your tools for treatment rather than pharmaceutical drugs. The Molecular Biology field starting asking this question in the 1970s of how to manipulate genes in cells and living organisms to prevent the expression of disease causing genes. Introducing new genes or modifying genes with experimental testing certain diseases are being able to be manipulated or managed. How will the genes be edited with those that have existing diseases present not just a gene known to cause disease? Not all genes can be manipulated – there will still need to be preventative action, people will still have illnesses as not everyone has access to genomic testing and information on how to prevent disease through gene therapy. How will all of this sophisticated knowledge be delivered to all types of people? For gene manipulation to work the editing gene has to be delivered at the right time, to the right cell in the correct controlled situation for it to work properly. Using Gene Therapy to Enhance Sport Performance Which if you didn’t hear in the 2016 Olympic Games there was testing for a gene known as EPO (Erythropoietin) within athletes. As this awareness has been around for a decade and through research and scientific understanding testing was made available for detection of EPO distributed through the AAV virus into the person’s genomes. With new technology emerging testing will and will not be possible depending on how the gene is manipulated or delivered into the athlete’s correct cells. Most are being edited through various agents/viruses that more often than not do leave a fingerprint or sequence that may be found in current approved tests. Other attributes of enhancing an athletes’ performance is to use gene therapy to knock out or minimize a gene such as Myostatin which may inhibit muscle cell growth and differentiation. This also can be tested by looking for a mutant myostatin gene – which may be detected by a mixture of several different genomes. Don't miss the Gene Based Dieting Live Webinar happening in Early December! Learn how your genes can predict your best dietary outcomes. With amazing outcomes of over 1500 clients within our medical practice.

Welcome back to the Ironman Executive Podcast where today we talk with Josh Mitteldorf, he is both a researcher and science writer. He recently released a book called Cracking the Aging Code which not only transformed my perspectives on aging but will bring awareness and knowledge into your own understanding of aging. Learn the importance of epigenetics in aging as we discuss current research, research that may happen over the short term and long term in the science world in regards to how reversing aging may be possible. Caloric Restriction There is good evidence that suggests caloric restriction does make you healthier and may add 5 to 10 years on your life. Why We Age Most professionals either believe it is the process of metabolism building up, there is the mathematical program or idea that it is within our cells and make up to age and the last is one of the evolutionary biology community where if it happens it must be good for us and our bodies just evolve alongside of everything else. ”Aging is not inevitable” Josh Mitteldorf We discuss examples of animals and creatures that use high energy and show no signs of ‘wearing out’ or aging compared to others that may die within only a few years of being born. Importance of Epigenetics in Aging We have the same genes all through out our life with epigenetics its all about what genes get turned on and when. That same program continues into our old age, aging is a continuation of the epigenetic program into a self destructive age. As research continues let’s look at the genes that are self destructive: inflammation, autoimmunity, the thymus gland that produces/trains T cells for our immune system shrinks with our age and the telomeres also get shorter with our age. To prevent these modes of self destruction there needs to be a solution to block these pathways from doing what they would naturally do – poison the body as the individual ages.  Is there a way to get rid of the cells that are senescence (dying off slowly) and overtaking room for healthy and viable cells to prosper. Be informed on what chances for anti-aging you are taking. Listen to research and the experts who have spent many years in this field before self-experimenting. Josh’s recommendation for maintaining a longevity lifestyle are: Vitamin D (without it you are susceptible to cancer, Alzheimer’s, and heart disease. Get a blood test for your Vitamin D levels and get them as close to 100 as you can. Most Americans are around the 10 or 20 mark and the recommended level is 30 and above. Magnesium has many benefits for your brain aging. Interval training: jump ropes, sprints, push ups a couple of times a day especially before you eat. Has powerful short term effects and.

Today we’re talking to Dr. Kelly Olson, an expert in the area of neuroscience, stress and sleep. We discuss chronic stress and adrenal fatigue, as well as some promising supplements and treatments to support healthy stress response and better sleep habits. Chronic Stress and Adrenal Fatigue We’re all aware of the negative impacts of stress, how it has a huge impact on aging and can create a low-grade inflammatory response that contributes to a high percentage of illnesses. Of course, there are also positive aspects to some types of stress. Acute stress can provide a benefit, but you need to be able to control both the physiological and psychological response, particularly as it relates to coming back down afterward. Our bodies are meant to be able to manage this response by bringing down the heart rate and elevated chemical levels associated with stress, but it doesn’t always work that way, which leads to chronic stress. Chronic or prolonged stress is associated with adrenal fatigue. But the problem with treating adrenal fatigue is that most practitioners go after the messenger instead of the source, which is akin to going after the symptom vs. the disease. Cortisol released from adrenal glands creates a negative feedback loop. But if the receptors aren’t there, as happens in adrenal fatigue progression, the system doesn’t work the way it should. Unfortunately, controlling adrenal function is often overlooked by doctors. Biofeedback for stress response has the ability to control the neural circuits, and cognitive behavioral therapy also helps people train themselves to be able to come back down from stress. Getting a Handle on Sleep The excess of chemicals in the brain like norepinephrine, epinephrine and cortisol can contribute to people’s inability to calm brain activity for a good night’s sleep. And sufficient and restful sleep is crucial for health and longevity – it’s our built-in process to combat stress, formulate memories and get the immune system on track. In order to get a good night’s sleep, all of the brain chemicals need to be properly balanced and work in concert together. Dr. Olson herself has suffered from cortisol inversion and low serotonin, which prevented her from getting the sleep she needed. Over time, she was able to correct this imbalance through a combination of methods targeting neurotransmitters, including adaptogens, 5-HTP and folate support. Eventually, she was able to get everything into a more normal range. Dr. Olson recommends these supplements for stress modulation: Ashwagandha, CortiCept, Phenibut and melatonin.

Today we’re talking to Dave Siever, an expert on the topics of neuro feedback and biofeedback. Dave discusses the audio visual entrainment (AVE) device – called the DAVID -- offered through his company Mind Alive, and how it can be used to optimize the brain in many different ways. Audio-Visual Entrainment vs. Audio-Visual Stimulation Dave explains how audio-visual entrainment is different from the audio-visual stimulation you’d get from, for example, watching TV, which doesn’t do much to benefit the brain. AVE, in contrast, provides a continuous stream of stimuli at a fairly steady frequency into the eyes and ears -- the device works simply by using headphones to pulse tones for auditory stimulation and glasses with lights that flash at different speeds for visual stimulation. And while people generally associate entrainment with brain wave driving, that is only a small portion of what it does. AVE also has dissociative benefits similar to meditation, increases endorphins, serotonin and blood flow to the brain, and has an autonomic calming effect. Flexibility Between Beta and Alpha Activity The beauty of the Mind Alive DAVID device is that it allows users to pick the frequency they want to entrain in the brain, practically making it a true panacea for an array of issues. Dave explains that beta activity in the brain is associated with actively doing something, whereas alpha frequency is associated with calm, meditative activities. He’s seen that staying in the low beta region is beneficial for learning and activities -- this type of “relaxed tension” is a band that peak performers like athletes and academics do well in. Meanwhile, increasing alpha activity in the brain can be helpful for people who have trouble getting into meditative states, or falling asleep. Dave points out that alpha intrusion gets in the way of focus, whereas people who are hyper-focused don’t have enough alpha activity and tend to be more rigid and don’t sleep as well. People have a tendency to be one way or another, and entrainment helps them to flex between the two states as needed. And it can be done anytime from home for as little as 30 minutes with the DAVID device. Treating a Variety of Issues The flexibility of audio-visual entrainment allows it to treat a broad variety of issues, purposes and disorders. Dave and his team have done two dozen studies on the DAVID devices to show their effectiveness for academics, seniors, and those suffering from depression, PTSD, sleep disorders and more, proving it to be the only technology that is so multifaceted. It can even be used to help children with ADHD to fall asleep at night, or to take the edge off on a daily basis for those suffering from addiction or anxiety. And for entrepreneurs, AVE can boost performance, attention and cognition. Make sure to check out… MindAlive.com

Today our guest is Dr. David Sinclair, who has seen the potential for aging reversal research to revolutionize medicine for the last 25 to 30 years. David explains that, like many children, he was morbidly fascinated with mortality at a young age, but he never really outgrew it. Now he’s determined to make life as long, happy, healthy and productive as possible for everyone on the planet, and also for humankind to be the best possible species it can while having the least possible impact on the planet. Aging Reversal Research Faces Challenges With all of the advances in genetic research, it’s pretty much a foregone conclusion that we will be able to genetically change our fate if we want to in the coming decade or so, although there will be a lot of debate about whether or not we should. Currently, at least 10 groups, including both companies and academics, are pushing to show that we can slow down or reverse the aging process in people. The challenge is not necessarily proving scientifically that it can work, as some molecules in human clinical trials have already shown positive results. However, the research still needs a big win in order to really drive attention. Also, funding this type of research can be quite a challenge, which has led some researchers, including Dr. Sinclair, to turn to crowd funding. Supplements That Have Shown Promise Resveratrol: One of the first molecules shown to delay aging, particularly when it comes to metabolism and inflammation. The most exciting development was a study last year finding that resveratrol not only altered progression of molecular changes, but also improved daily function and seemed to prevent cancer. Pterostilbene: Could be even better than resveratrol in some ways, but not enough research has been done to demonstrate this definitively. Nicotinamide Mononucleotide: This shows a lot of promise when it comes to aging reversal. It works because it is one of few molecules that the body can turn into NAD, which is a cofactor for metabolic reactions that declines as the body ages. The hope is that this will initiate a reversal of the aging process, and studies in mice have shown as much. However, nicotinamide mononucleotide has not been used in human trials yet because researchers are currently gathering more data on safety. N icotinamide Riboside: This is currently available as a supplement, including Basis by Elysium. It also has been shown to raise NAD levels in mice, although more human studies need to be done. TA-65: This supplement has been shown to boost telomeres, but Dr. Sinclair explains that it is not a silver bullet that will reverse all aspects of aging. As far as his own approach to overall health and longevity goes, Dr. Sinclair simply takes resveratrol, as well as a statin and aspirin, and watches what he eats. He explains that he’s still working on making the next multi-active molecule that is safe enough for humans, and then he’ll take that. Resources Basis by Elysium

How To Combat Diseases of Aging Caused By Oxidative Stress With Dr. Mark Gordon Today we’re talking to Dr. Mark Gordon, a physician with over 20 years of experience in clinical cardiology. Dr. Gordon has participated in numerous pharmaceutical and medical device trials, and his passion for prevention has led him to focus his practice on preventative and integrative cardiology. Dr. Gordon is currently focused on the hot topic of NRF2 and how it helps the body deal with oxidative stress, which is the root cause of hundreds of diseases. He explains that oxidative stress is like a rusting of the body from the inside out. It is created from free radicals, which are the highly unstable and destructive byproducts of metabolism created by our bodies every day. The Relationship Between Oxidative Stress and Free Radicals Dr. Gordon explains that oxidative stress and free radicals go hand in hand. And while some free radicals are actually beneficial – they can help heal infections by targeting bad bacteria — those produced above and beyond what’s necessary are responsible for diseases of aging like cancer and cardiovascular diseases, among countless others. Oxidative stress is essentially the free radical process run wild, which in turn causes damage to the cells. For many years, the popular wisdom was that people could simply take loads of antioxidants to combat this process. But over the last 10 to 15 years, studies have shown detrimental effects of taking too many direct antioxidants. Not only is it an ineffective way of dealing with oxidative stress that doesn’t reduce the risk of cardiovascular disease and cancer, it can also actually increase the risk in some individuals in whom the antioxidant is converted to a pro-oxidant. Researchers are still learning more about this process, but the answer in the meantime is to boost the body’s built-in antioxidant defense system to buffer these effects, as opposed to relying on external sources. Our body produces its own enzymes to combat the adverse effects of oxidative stress. But as we age, we produce fewer of this enzymes, giving free radicals more free reign to do damage. How To Boost the Body’s Own Defense System Around 2002, scientists dived into a hot new area of research revolving around NRF2. NRF2 is a messenger protein in all of the cells in the body that goes into a cell’s nucleus and turns on genes that code antioxidant proteins to fight off free radicals, thereby reducing oxidative stress. We are born with the ability to make NRF2, and this system is critical for healthy aging. As we age, there are several things that we can do to boost the body’s innate NRF2 system. Appropriate exercise: Daily moderate exercise (not too much and not too little) is essential. Cleaner Diet: Key ingredients in certain foods activate NRF2. These include foods featured in the Mediterranean and Okinawa diets. The standard American diet doesn’t contain most of these necessary components. Meditation: The cells in the brain don’t know don’t know whether stress is psychological or physical, so the response is the same — inflammation and oxidative stress. This is why meditation, prayer and other calming practices are effective. Protandim by LifeVantage: This supplement is derived from five plant-based ingredients based on traditional Chinese medicine and boosts NRF2 production in the body. Studies have shown it to be the most potent biochemical pathway to combat oxidative stress, and it is considered in the medical community to be an extraordinary therapeutic and preventative breakthrough. Make sure to check out… Protandim by LifeVantage

How To Differentiate Between Fear and Anxiety Today we’re discussing fear and anxiety with neuroscientist Joseph LeDoux, Professor of Science at the NYU Center For Neuroscience. Joseph’s work focuses on the brain functions of memory and emotion, and he is the author of The Emotional Brain, Synaptic Self and Anxious. In our society, three quarters of all medical visits and 60 percent of medical conditions are directly associated with stress. This begs the question: How can we take control of how stress affects our physiology? How the Brain Responds To Danger When we are in danger, we both feel afraid and act afraid, which confuses the two things in our mind. Joseph explains that the conscious experience of fear is actually generated separately from the brain’s response to danger. The feeling of fear doesn’t come from the amygdala like the response to danger. Rather, it is put together in the neocortex like any other conscious experience. In order to feel afraid, you have to be aware that you’re having that experience, so Joseph doesn’t believe in unconscious fear. To break it down even further, Joseph points out that the conscious experience of fear includes several elements: 1) perceptual stimulus, e.g. a snake, 2) long-term memories associated with that perception, e.g. “snakes are scary” and 3) the physiological responses of the amygdala, e.g. tensing of body. These three things combine to create what he calls a “fear schema,” which compels a feeling of fear. Joseph underscores our need to break out of antiquated ideas about fear and anxiety – we must completely separate our use of the terms “fear” and “anxiety” to describe responses that happen unconsciously. The amygdala doesn’t feel fear; fear is actually a highly cognitive process that involves an integration of information from the defense response of amygdala with perceptional information and long-term memories about the stimulus and the fear schema. Top Three Ways to Achieve a More Bulletproof Life People feel guilty when they’re anxious or hypersensitive to threats – remember that it’s not your fault; each of our brains is wired differently. We don’t have a lot of natural ability to regulate these initial reactions. We can through training methods, e.g. psychotherapy and coaching methods, learn to be more active copers as opposed to passive copers in order to gain some control. Proper breathing is the most effective way everyone can reduce stress. It also relaxes muscles and helps you to sleep better. When you’re breathing properly, you’re training the parasympathetic nervous system to counteract the fight or flight response generated by the sympathetic nervous system. Make sure to check out… Joseph’s book, Anxious Joseph’s band, The Amygdaloids

Today we’re talking with Wellshift CEO Melanie Weinberger, who is currently transforming corporate wellness to show people how to create and maintain epic health transformations in the workplace. Unhealthy Effects of the Workplace Melanie spent six years in the world of corporate advertising, and realized that she was depressed for four of those years due to an unhealthy work environment. She realized that the workplace is one of the most detrimental environments to our well being, largely because people make choices in order to get external validation as opposed to improve their well being. Melanie decided to flip that environment around and created Wellshift, a corporate wellness model that takes a completely new approach. Melanie discovered early on that there were some problems with the traditional corporate wellness model. For example, on-site exercise classes tend to attract only the people who are already exercising. Another issue with many corporate wellness providers is that they take a “what’s wrong with you?” approach, as opposed to asking people “how can you be amazing?” Wellshift’s Unique Approach to Corporate Wellness Wellshift has about twice the participation of most corporate wellness programs, and the following practices have been key to the company’s success: 1. Treat the whole organization as a community, as if the company is one human being. Think of each department as one of the body’s organs so that everyone is working together in synergy to create an optimal output. 2. Remember that healthy habits are very contagious, so start by working with a small seed group, and then more and more people will join in. 3. Present a specific challenge, such as improving posture, each month, and then deliver micro tasks every morning to help people practice their new habit until it becomes learned. 4. Keep the size of the challenges small – for example, 10 minutes of walking at a time -- so that they don’t interrupt the work day, but actually blend in with the day’s flow. Wellshift to present at SXSW Melanie is very excited about Wellshift’s upcoming appearance at SXSW, where the company will not only co-present Google for Entreprenuer’s Wellness Lounge, but will also give the talk “Cracking the Code To Your Unlimited Epic Potential,” which will discuss what it really means to dive deep into your subconscious mind and intentionally create your reality. “You can be absolutely epic and we’re here to help you get there.” – Melanie Weinberger of Wellshift” Make sure to check out.. Wellshift.com Cracking the Code To Your Unlimited Epic Potential

Today’s guest is Dr. Ruthie Harper of SKINSHIFT, a revolutionary skin care product line customized to each individual’s genetic profile. Dr. Harper shares her inspiration for developing a skin care system based on her powerful belief in the impact of personalized medicine. “A one size fits all approach doesn’t apply to skin care any more than it applies to medicine.” Personalized Medicine Meets SkinCare Dr. Harper became determined to find a more functional approach to medicine when she noticed early in her career in conventional medicine that she never saw anyone get well — people would enter medical system and never leave as they were prescribed more medications, developed more side effects, and had to see more doctors. That’s when she decided to look at what would get people healthy again, specifically by focusing on nutrition, lifestyle changes, natural hormone balancing and exercise.Dr. Harper also began to study the basic biochemistry of body and observed amazing transformations when she started to focus on how vitamins and minerals optimize overall health, as well as outward appearance. 5 categories of skin health The unique focus of SKINSHIFT is to look deeper and help people pick more effective skin care products for their genomics, so Dr. Harper looks closely at each individual’s single nucleotide polymorphisms (SNPs) — which are the differences in a person’s genetic code — and how that can influence skin function. This determined the following five categories of skin health addressed by the SKINSHIFT product line: Collagen formation – This contributes to youthfulness and elasticity in the skin. Sun protection – Despite popular belief, darker skin is not necessarily more protective from UV damage. Antioxidant protection – How your innate built-in system protects the skin from free radicals. Glycation – The process whereby if you have elevated levels of blood sugar, it can coat important protein structures in the body, which is harmful to the organs, including skin. Sensitivity – How pro- or anti-inflammatory your genetic coding is. Overcoming genetics with product matching There is a popular misconception that if something is in your genetics, it’s a done deal, but nothing is further from the truth. The body is remarkably resilient, and the skin is a vital, vibrant organ — if you’re aware of what you’re working with, you can go in and support the genetics in a meaningful way to get a different outcome.Dr. Harper points out that there are lots of good skin care products out there, but two different people, even sisters, could have vastly different experiences with same product — the ingredients need to be matched to the right individual. Individuals interested in taking advantage of this approach begin by swabbing their cheek and sending that in for analysis. From there, Dr. Harper ranks each of the five skin care categories from highest to lowest priority based on that analysis, and recommends her SKINSHIFT serums and supplements accordingly. “Food is your tidal wave and supplements are your current. You can’t change your skin health if you have bad eating habits – Dr. Harper.” Additional tips for optimal health and a youthful appearance While the SKINSHIFT line focuses on creating a youthful appearance, Dr. Harper has some additional tips for achieving overall health and well being. Most people are deficient in vitamin D, even if they’re getting daily sun exposure. Vitamin D is critical for breast and prostate health, immune function, and even skin care prevention, so take a good Vitamin D supplement. Consider taking Vitamin K2 in conjunction with Vitamin D to keep calcium in the bones. When choosing sunscreen, remember that a higher SPF isn’t actually ideal, as these formulations typically contain more harmful chemicals. Instead, apply liberally and reapply throughout the day when you’re going to be in the sun. Also choose non-organic formulations, such as titanium oxide, to create a barrier block from the sun’s rays, as opposed to chemical formulations. Make sure to check out… Skin Shift

Our guest today is Liz Parrish, founder and CEO of BioViva Science USA, a company committed to extending healthy life spans using gene therapy. Liz shares the advances BioViva has made in gene therapy research, as well as her own experience undergoing one of their pioneering therapies, which may make her the first human GMO. Liz Parrish of BioViva wants to genetically engineer you. Telomere Attrition and the Disease of Biological Aging Liz is a humanitarian who was initially drawn to reversal of aging research through her interest in curing childhood disease. Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, and the shortening of those telomeres begins from the moment we are born. This telomere attrition is responsible for biological aging, which underlies almost every disease. Liz and her team at BioViva want to not only extend people’s life expectancy, but to allow people to live to be 120 or older in a youthful and capable way by tackling biological aging as a disease in and of itself. Part of what makes this research so exciting is the fact that extending healthy life spans has broad-reaching humanitarian implications. If we become a healthier and longer-lived population, that increases our humanitarian outreach, how we cultivate land and how we see the future. In short, we make better choices. Overcoming the Negative Reputation of GMOs GMO has developed a bad reputation due to its use in food products. But treating humans as GMOs is a different story. For example, no one would malign children who undergo gene therapy for muscular dystrophy. When looking at a new medical science, it’s important to keep in mind that all modern medicine was considered heresy at some point. Liz wants to stress that gene therapy isn’t scary, but rather an eloquent and beautiful science — disease mitigation at its best. The injection of genes directly into your cells is a cleaner, better process for your body without the negative side effects that come with taking pharmaceuticals. We see the most benefit when we tackle biological aging as opposed to spending billions of dollars on trying to cure individual diseases. The key is for the NIH to recognize biological aging as a disease in and of itself, which will open up funding and resources for researchers. When you get older, you don’t look in the mirror for as long.” – Liz Parrish of BioViva. What Comes Next…And What Do We Do While We Wait? The next step is for BioViva is to run a clinical trial against a disease – Alzheimer’s is the best candidate — in order to ensure the therapy is safe and eventually make it available to the public. In the meantime, Liz reaffirms that the best way for individuals to increase life span is through moderate exercise every day, a healthy diet and avoiding the consumption of excessive sugar.

Our guest Michelle Ricker is a Registered Dietitian and Certified Health & Fitness Instructor. She is one of the founders of FitNow Health, which specializes in providing DNA-based Nutrition and Fitness programs. She chats with us today about how genetics affects our overall well-being and the benefits of a genomic-based dietary approach. The Genomic-Based Dietary Approach A 2014 study conducted by the European Society of Human Genetics showed that people who followed a diet based on their genetic profile lost 33% more weight and built more lean body mass. It is clear that genetics plays a significant role in how our dietary and fitness habits affect our health. Genomic tests can reveal a number of things, including how your genes relate to sodium and sugar sensitivities, the production of appetite controlling hormones, and insulin resistance. All these genetic factors explain why the same diet works well for some people and doesn’t work well for others. The benefit of having a clinician examine your genetic profile is that you won’t have to waste time testing different diet plans until you find the right one. With genomics you can narrow things down right from the start. FitNow Health FitNow Health is a consulting practice founded by Michelle that specializes in DNA-based nutrition and health. Based on your genetic profile, Michelle and her team create a detailed, user-friendly program designed specifically for you. The Role of the Clinician Genetics is probability based and it is the role of the clinician to interpret a client’s genetic profile. Genetic information is valuable, but you need to understand what to do with it. Using their extensive experience and training, a clinician can create a lifestyle plan that alters a client’s genetic expression to optimize health and well-being. Oftentimes, clients are unaware of the true impact of genetics and may engage in dietary habits that they perceive as healthy, but are in fact in opposition of their genetic profile. This is where a clinician can step in and steer the client down a different path that makes it easier to instill the lifestyle changes that will have a positive impact on their well-being. The Future of Genomics and Health Genomics has promising applications for professional and Olympic athletes. Information gathered from genetic profiles can improve training programs, enhance nutrition to maintain endurance, and help athletes recover properly. From a nutritional perspective, Michelle hopes that DNA-based approaches will soon make a difference in mainstream weight loss and have a positive impact on the current obesity epidemic. Resource Links Fit Now Health 23andMe Apeiron Center for Human Potential

Our guest Michelle Gielan is a former national news anchor at CBS. After getting tired of telling negative news stories, she began studying how to deliver negative news in a way that empowers people and helps them see a path forward. What she discovered is that the messages we choose to talk about can transform how people view their world. Dealing with Negative News Maintaining a positive and optimistic mindset in the face of negative news or people is important. If someone is being negative around you, engage in a strategic retreat. For example, if you are in an office environment and the person sitting next to you is engaging in a negative phone conversation, you could put on noise canceling headphones or reorient your desk. Small changes like these can really transform your day at the office. The less negative and useless information you’re exposed to, the less you’re going to retransmit negativity to other people. Transforming Negative Interactions with Other People While as a society we tend to believe that we can’t change people, this isn’t quite true. You can transform your interactions with negative people by creating a string of positive experiences with them. As a result, you are effectively rewriting the narrative between yourself and them. For example, if someone is constantly complaining about the boss, you are blessing the situation by engaging with them. If you steer them in the positive direction instead, this will foster less negative water cooler talk and more solutions-focused discussions. Changing Your Mindset with Positive Habits When we engage in positive habits, we can change our levels of happiness, optimism, and wellbeing. Simple gratitude exercises can change how you view the world. The key is to establish these habits and maintain them in the long term. To do this, keep exercises new and different to help establish a routine. Eventually these positive habits will transform your mindset and help you build new neural pathways. Where our Happiness Comes From 10% of our long term happiness come from our external circumstances 40%-50% comes from our baseline level of happiness 40%-50% comes from how we process the world. More and more, studies are showing that how you think can influence how you experience the world. Influencing Your Environment People often wonder whether a negative or positive person has more influence in an environment. Studies show that it is neither – the most expressive person is the one who wins the battle for culture. In a business environment, you can increase your chances of success by encouraging expressions of positivity in the office or in meetings. The key is to maintain a healthy ratio between positivity and negativity. Start Your Day on a Positive Note A recent study showed that watching just 3 minutes of negative news each day increases the likelihood of a person reporting their day as “bad” 6 to 8 hours later by 27%. Don’t start your day with negative news Instead, seek out for transformative news stories. These are solutions-focused stories that will help you start your day off on a positive note. If you have a commute, craft this time into something that is fueling – listen to podcasts or audiobooks that help your brain get in the right state of mind for the day. Fact Checking Michelle has a technique called Fact Checking that she uses to deal with stressful situations. 1. Write the stress down2. Write down the reasons why you feel this way3. Write down some positive aspects of the situation This short process calms the brain down and helps it transition from a default of stress to a default of thriving. Top Lifestyle Tips to Create More Positivity Power Lead: Start conversations, emails, phone calls, and meetings with something positive and meaningful to set a positive tone. E-mailing Positivity: Before you look at your inbox, open up a new message and write a 2-minute email from your social support network and tell them why they’re meaningful to you.

Our guest this week is Dr. Jeffrey Fannin, an expert in mapping and analyzing the brain. Dr. Fannin holds a PhD in psychology and has over 15 years of experience in the neuroscience field. His research in neurofeedback technology has led to teaching opportunities at Arizona State University and collaborations with West Point Academy and Dr. Joe Dispenza. He is the founder of the Center for Cognitive Enhancement, which has partnered with Thought Genius and is primarily focused on enhancing and optimizing normal brains through 3D brain mapping and neurofeedback. In our interview Dr. Fannin shares with us the science and some of his thoughts behind: Rewiring your brain through neurofeedback Accessing all your mental faculties by achieving the whole brain state The neuroscience of leadership   Enhancing the Brain with Neurofeedback The neurofeedback process trains the brain into a peak performance state. Through the use of EEGs, low resolution electromagnetic tomography (LORETA), and standardized low resolution electromagnetic tomography (s-LORETA), you can build a 3D depiction of the brain and look at what the brain is doing. Through this type of brain mapping, it is then possible to build a protocol that tells the brain what you want it to do using neurofeedback. How Neurofeedback Works Neurofeedback analyzes 20 different spots on the brain and rewards it for following the protocol with 16 different auditory variables. The process utilizes as many as 5700 variables and does not require conscious decision-making on the part of the participant. This is because while the cortex processes information at 40 bits/second, the lower part of the brain processes at 40 million bits/second. Following multiple neurofeedback sessions, new dendrites form and new neural pathways develop based on the provided protocol, and the brain is effectively rewired. Brain Brightening Brain brightening is recommended for individuals who consider themselves healthy, but feel they have lost a bit of their edge or are experiencing reduced clarity. A lot of this can be due to age, as the brain begins to slow down a half cycle per decade starting from agee 37. Brain brightening measures the energy centers of your body with your eyes opened, eye closed, and while performing task (e.g. reading). Based on these three states, modifications to your emotional or physical energy can be made to act like a tune up for your brain and reinvigorate it. The Neuroscience of Leadership In a collaboration with West Point Academy, Dr. Fannin spent four years examining the numerous factors important in neuroscience and leadership. Together with a business professor, he later taught the Neuroscience of Leadership at Arizona State University. As a part of the curriculum students took part in brain mapping and neurofeedback training. By the end of the course every single student had improved his or her processing speed. As a result of his extensive research, Dr. Fannin has developed device protocols designed to help executives in their thinking, allowing individuals with normative brain patterns to train as peak performers. Subconscious Beliefs and the Whole Brain State Your core belief system is made up of thoughts you’ve had over and over again, and this includes subconscious thoughts you may not even be aware of. Thoughts vibrate at a particular frequency, and holding a thought for 68 seconds builds enough energy to affect particle matter. Subconscious programming teaches you to manage the energy information in your body, which in turn enables you to manage your thoughts. [Tweet: “All thought is nothing more than energy and information @DrFannin”] After receiving a protocol, a significant shift in the brain occurs. The whole brain state is a method for changing subconscious belief patterns rapidly and allows an individual to have access to all of his or her mental faculties. The result is an improved transfer rate between left and right hemispheres, as well as good harmony between the front and back of the brain. Muse Headband Muse Brain Sensing Headband is a commercially available device that is ideal for relaxation. The device contains four electrodes - two in the front and two in the back - that measure your thoughts (e.g. positive or negative perceptions and emotions). When used in conjunction with software, you can begin to change your thinking through neurofeedback technology.

Dr. Dan welcomes Andrew Hill, PhD to discuss the chemistry and electrophysiology of optimal brain performance. Dr. Hill is involved in the company, TruBrain, a nootropic brain enhancing supplement and a researcher and clinician in the field of cognitive neuroscience. So if you are interested in ways to tap into the true potential of your brain, listen in.

In this episode Dr. Dan welcomes another young Russian researcher that is focused on aging. Specifically she is focused on skin aging. Her name is Polina Mamoshina and she works for a bioinformatics company by the name of Insilico Medicine, Inc. Her research fosus is on skin aging biomarkers and photoaging of the skin. We discuss why sunscreen might be a very bad idea, what can we do now to slow or correct skin aging, and what does the future hold for reversing skin aging.

Dr. Dan welcomes human movement coach Moses Goldstein. Mo is the movement coach and massage therapist at the Apeiron Center for Human Potential. He initially assesses how people move as a function of daily activity - gait, bending, lifting, and squating. He finds that most people are not moving in ways that are most beneficial to their bodies and that many musculoskeletal issues can be easily corrected by paying attention to the way we move.

Dr. Dan interviews the FLOW Genome Project co-founder Jamie Wheal about the FLOW state. This is a deep dive into the philosophy and science of the FLOW state. Why is FLOW desirable? Why do you not want to be in it all the time? What does it have to do with bliss? How can I get into FLOW? Entheogens, neurofeedback, flow hacking, biohacking, alpha/theta

0 0 1 44 254 Physiologix 2 1 297 14.0 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin;} In this episode, Dr. Dan answers questions submitted by listeners. Topics: Whats new in longevity research? What is human potential medicine? Should we have iodine levels checked for thyroid issues? What is the best technology for stress optimization? Should I monitor my oxidative stress levels?

Dr. Dan interviews Dr. Isaac Jomes. He is the founder of Designer Health Center and host of the podcast and website - Super Human Entrepreneur. Dr. Jones and I take on the issues of utilizing current medical knowledge and technology to enhance human physiology and brain function. We discuss the issues of toxicity in society and the need for stress resiliency.

Dr. Dan welcomes back Esther Blum, MS, RD. She is a registered dietitian from New York and the author of Cave Women Don't Get Fat.

Dr. Dan shifts gears a little with business coach Dr. Jim Alvino. The discussion plays into the crossover between Dr. Dan's views on health and how the quantum mind creates health. Jim sees the parallel in the business community. He teaches business owners and entreprenuers how to tap into the quantum science of business.

Dr. Dan welcomes visionary entreprenuer Ariel Garten from IntrerAxon. She is a neuroscientist and her company has developed the MUSE brain sensing headband. We discuss the era of the brain and how technology is making it possible to create brain states for optimized cognitive performance and stress resiliency.

Dr. Dan talks with clinical psychotherapist Ava Diamond about mental fitness coaching. Find out what mental fitness really means and how training mental fitness with help you to overcome the limitations of our subconscious mind. Ava Diamond helps executives, entreprenuers, professional athletes, and anyone in search of living the epic life. Topics discussed: Mental fitness coaching Stepping out of the box Journey over destination Importance of sleep Hormones Visit her website at www.AvaDiamondLCSW.com

Dr. Dan discusses the various different health options from allopathic care to alternative. He specifically discusses Contemporary - allopathic medicine Functional medicine Alternative care Holistic medicine Age management or anti-aging Concierge medicine Preventative care Human potential medicine

Dr. Dan answers viewers questions and reviews current news on the topic of biohacking optimal health. Topics discussed Genomics conference review genes for obesity & weight loss nutrition genes supplementation genes MTHFR update Understanding TSH Psychadelics Meditation and brain changes Daily supplementation

Dr. Dan welcomes Dr. Eldon Taylor, expert in the unconscious programs that reside in our mind. Dr. Taylor is a prolific writer and recognized expert in the field of psychology. He is a blogger and has written over a dozen best selling books of the subject of the unconscious mind. Topics: The programs that control our thoughts Is there such a thing as original thoughts How do we regain control of this programming Positive self-talk Role of psychedelic drugs

Dr. Dan talks about peak performance for the executive, the entrepreneur, and the professional. Learn what the top 1% of achievers know and how to get there yourself. The second half of the show is an interview with Seth Blaustein co-founder of Voice & Exit. Topics: Voice & Exit Festival Brain hacking technology MUSE HeartMath Versus headset FLOW state

Join Dr. Dan as he welcomes Les Dethlefsen, PhD from the David Relman Lab at Stanford University. He is heading up the intestinal ecology component of the Human Microbiota Project and has some really eye opening information. Topics: Is gut microbiome testing ready for clinical application How can we influence the microbiome GMO's and the gut The Human Microbiota Project Your study vs. the American Gut Project Earn money and get a great report from your stool Links: http://humanmicrobiota.weebly.com/about-our-study.html  Eligibility: https://redcap.stanford.edu/surveys/?s=vTQYETeZCb

In this episode Dr. Dan answers listeners questions that have been submitted regarding health & wellness. Topics: PaleoF(x) 2015 wrap up and review Enquos Voice & Exit Bulletproof products Reflux meds and bone density Metformin indications Tech for meditation 23andMe reliability and predictability Peak cognitive performance Nootropics: getting started Nitric oxide monitoring

In this episode Dr. Dan answers listeners questions that have been submitted regarding health & wellness. Topics: PaleoF(x) 2015 wrap up and review Enquos Voice & Exit Bulletproof products Reflux meds and bone density Metformin indications Tech for meditation 23andMe reliability and predictability Peak cognitive performance Nootropics: getting started Nitric oxide monitoring

Dr. Dan discusses optimizing sleep. This is such an important aspect of optimal health and as many as 90% of people are chronically sleep deprived. Dr. Dan spends significant time with his clients in order to optimize sleep because he sees it as one of the foundations of optimal health. Topics discussed: What is optimal sleep and sleep deprivation Consequences of inadequate sleep Stages of sleep Sleep hygiene Supplementation for sleep Sleep biohacks

Dr. Dan interviews Deborah Gordon, M.D. about the utilization of genetic testing in clinical practice. In this episode: MTHFR Nutrigenomics 23andMe Individualized medicine Contemporary vs. Traditional medicine

Dr. Dan interviews Kenya K. Stevens ‪#‎jujumama about the sacred sexual practice of Tantra. Topics to be discussed include: · Understanding gender harmony· Progressive love, polyamory· Overcoming sexual inhibitions· Unconditional love    

Dr. Dan welcomes fitness training guru, author, and all around awesome guy, Dan John. Dan stops by to talk about ways that we can biohack our fitness routines in order to achieve desired goals. Dan John is always a fun and happy guy to interview and he has a wealth of knowledge to share. In this episode: Nutrition and lifestyle optimization Training techniques to achieve specific goals Sleep Wearable technology

This episode is part 2 of Biohacking Flow. In this episode Dr. Dan welcomes Dr. Leslie Sherlin to talk about the electrophysiological brain patterns associated with the flow state. Topics discussed: Are there EEG patterns associated with the Flow state? Can we train our brains for flow? Why should we want flow? Tools to train the brain

Part 1 of a 2 part series on Biohacking Flow. In this episode, Dr. Dan speaks with Steven Kotler, author of The Rise of Superman and the director of research at the Flow Genome Project. Tpics discussed: What is flow and why should we strive for it What are the benefits How do we achieve this state Role of psychedelic drugs

Join Dr. Dan as he discusses the current state of anti-aging research with USC PhD student Maria Konovalenko. Maria is on of the young guns in the anti-aging research community and has a passion and a goal of youthful longevity for all. Discussed in this episode: When can we expect significant human longevity What steps are necessary to achieve the goal of longevity Currently available options Glucophage Rapamycin Ibuprofen Nicotinamide riboside TOR inhibition www.longevitycookbook.io her website

Dr. Dan welcomes integrative physician DeWayde Perry, M.D. to discuss the changing paradigm of medical care from a sick care model to well care and health optimization.  Topics discussed: Understanding the health optimization model Individualizing care Performance enhancements Testosterone replacement therapy: male and female Micronutrients

In this episode Dr. Dan talks with Justin Feemster from Nootropics City about the use of nootropic supplements to improve brain function. He also interviews Dave Monohan, CEO of Fitlinxx about their amazing new game changing wearable technology - AMPstrip. AMPstrip portion: The ultimate wearable technology for the biohacker www.AMPstrip.com Join the Indiegogo campaign Nootropics What are nootropics How do they improve brain function How do you stack for optimal performance www.Nootropicscity.com

Dr. Dan interviews the Bulletproof Executive, Dave Asprey about his new book The Bulletproof Diet and other aspects of biohacking life. In this episode: Biohacking with your physician Bulletproof eating Bulletproof coffee Food and mold toxins Peak performance biohacks Alpha-theta training Cold thermogenesis Paleof(x)

In this episode Dr. Dan defines biohacking and how it plays a role in creating individualized optimal health. Discussed in this episode: What is biohacking Types of biohacking lifestyle technology transhumanism The changing role of the physician Biohacking with genetics

In this special Q&A edition Dr. Dan takes on the controversial topic of childhood vaccinations. Do they work? Are they necessary? Are there risks?

Join Dr. Dan as he welcomes Dr. Martin Kohlmeier, one of the worlds leading researchers on the interaction of nutrition and genetics. Author of Nutrigenetics. Topics discussed: What is nutrigenetics/nutrigenomics? Where are we with clinical applications? Evidence based medicine vs. n=1 personalized medicine? ISNN conference

Join Dr. Dan as he welcomes Dr. Malcolm Kendrick, physician and author. He wrote the top selling book on cholesterol, The Great Cholesterol Con and has recently published Doctoring Data.  Topics discussed: What is Doctoring Data about? How much should we trust medical research studies? Evidence based medicine, not what we think? Role of personalized medicine?

Join Dr. Dan and Dr. Warren as they discuss tips and tricks for weight loss. Dr. Dan has over 15 years of experience in the weight loss world having performed over 3000 gastric bypass surgeries and evaluated over 10,000 people for weight loss and he shares his insights. Dr. Warren has been working with fitness competitors and other body sport competitors for several years and shares what he has learned. Topics discussed: Formulating an eating plan Food selection How to biohack for success Cold thermogenesis Sleep Exercise

Join Dr. Dan as he welcomes William Andrews, PhD, the worlds leading researcher and expert on telomeres. He is the CEO of Sierra Science, a company that is dedicated to curing aging. He is also featured in the critically acclaimed documentary: The Immortalists. Topics discussed: What are telomers and telomerase? How do we test our levels? What can we do to optimize our telomeres? What supplements support this process?

Every week Dr. Dan answers your questions relating to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected]. This week's topics: New live show coming February 2015 DASH diet and sodium sensitive hypertension Treating low bone density Frequent night time urination In the news: New heart disease biomarker Longevity gene Selenium levels and health

Join Dr. Dan as he welcomes professor Aubrey de Grey. Dr. de Grey is the Chief Science Officer of the SENS Research Institute and is a leader in the field of longevity. He feels that human life has the potential to be extended 100's of years while maintaining youthful physiology. He is also featured in the critically acclaimed documentary: The Immortalists. Topics discussed: Is substantially extended human life-span possible? Will we see it in our lifetime? What technologies are necessary to get there? Where are we currently?

Every week Dr. Dan answers your questions relating to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected]. This week's topics: Cold Thermogenesis progress Vitamin D and weight loss What is the best way to intermittent fast? In the news: Oxytocin and stress response Genetic based dieting Fortetropin for myostatin inhibition

Join Dr. Dan and Dr. Warren as they discuss cold thermogenesis with Jack Kruse, M.D. Biohacking cold thermogenesis Science of CT The CT protocol

Every week Dr. Dan answers your questions relating to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected]. This week's topics: Sedona Retreat Smoking Hookah Best commercial weight loss programs In the news: Shift work and cognitive decline Mothers pre-pregnancy weight and offspring health Oral microbiome and kissing  

Join Dr. Dan as he discusses the topic of sleep with Dr. Kirk Parsley. He is a former Navy SEAL and served as a physician for the SEAL teams. He specializes in optimizing health and has special training and interest in the affects of sleep on our health. How sleep deprivation affects our physiology Long term consequences How do we achieve optimal sleep

Every week Dr. Dan answers your questions relating to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: -Sedona retreat registration - What isthe best form of magnesium supplementation? - Is there a form of female Viagra? - How do I get started with meditation? Link to Vipassana meditation instructions In the news: - Genetic heart protection genes - Genetcs behind the health benefits of alcohol - Flame retardant toxicity in humans

Join Dr. Dan as he discusses the multigenerational effects of nutrition, drugs, and chemicals on our genes with Jill Escher, JD, MA. She is the President of the Autism Society San Francisco Bay Area, and philanthropist, Escher Fund for AutismHer current areas of focus include (1) developing new models for sustainable and affordable community-based supported housing for autistic adults, and (2) piloting research on fetal germline disruptions, both genetic and epigenetic, caused by acute fetal toxic exposures, such as to pharmaceuticals and smoking. Topics discussed: epigenetic inheritance autism influence of nutrition on germline epigenetics influence of prescription drugs on epigenetics

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: -Sedona retreat registration -How personalized can we currently get with the genetic testing (caffeine sensitivity, cholesterol, nutrients passed on during breastfeeding, toxin exposure) 23 and Me genetic testing -My serum cortisol keeps coming back normal but I have all the symptoms of adrenal fatigue, insights? -Academy of Nutrition and dietetics conference update of sports nutrition. In the news: - skinny people microbiome     - Stem cells in parkinson    

Scott Johnson is the bestselling author of five books and more than 250 articles featured in online and print publications. He holds a doctorate in naturopathy and is a board certified Alternative Medical Practitioner (AMP), Certified Clinical Master Aromatherapist (CCMA), and Certified Professional Coach. Getting started with essential oils Health specific uses sleep stress attention immunity Benefits of essential oils

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: -What dose of vitamin D do you recommend? -In your podcast with Nathan Bryan he mentioned how to test your extrinsic nitric oxide system, can you explain that again? -What diet do you think is perfect for our physiology? In the news: - milk does not do the body good - gut bacteria and shift work/jet lag   -Next wellness retreat info  

Dr. Nathan S. Bryan is an Assistant Professor of Molecular Medicine within the Brown Foundation Institute of Molecular Medicine, part of the School of Medicine at the University of Texas Health Science Center at Houston. Dr. Bryan has been involved in nitric oxide research for the past 15 years and has made many seminal discoveries in the field. These discoveries and findings have transformed diagnosis and treatment of many chronic diseases associated with NO insufficiency. Join Dr. Dan  and Dr. Bryan as they discusses: Importance of nitric oxide in health Diseases related to NO insufficiency Nitrates and Nitrites are good for you Why bacon is awesome! How to get more NO   0 0 1 38 220 Physiologix 1 1 257 14.0   Normal 0 false false false EN-US JA X-NONE   /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";}  

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: Ebola quarantine Berkey Water Filters Choosing fish oils Fruit not part of a healthy diet?  Upping your immune system during flu and cold season New technology with stem cells  Wednesday podcast guest info  

Dan John has spent his life with one foot in the world of lifting and throwing, and the other foot in academia. An All-American discus thrower, Dan has also competed at the highest levels of Olympic lifting, Highland Games and the Weight Pentathlon, an event in which he holds the American record. Dan spends his work life blending weekly workshops and lectures with full-time writing, and is also an online religious studies instructor for Columbia College of Missouri. As a Fulbright Scholar, he toured the Middle East exploring the foundations of religious education systems. His books, on weightlifting, include Intervention, Never Let Go, Mass Made Simple and Easy Strength, written with Pavel Tsatsouline as well as From Dad, To Grad. Join Dr. Dan and Dr. Walsh as they discuss getting back to the basics of fitness with Dan John The overhead squat Peri-workout nutrition The core exercises Building muscle Gaining strength Visit Dan John's website for more info: www.DanJohn.net   Dan has offered a free version of his book From Dad, To Grad click here: Dad to Grad

Digestive care expert Brenda Watson joins Dr. Dan and Kendall to discuss her 20 year career dedicated to helping people achieve vibrant, lasting health through improved digestive function. Brenda is the author of the brand new book, Skinny Gut Diet. She's been featured on PBS, The View, and The Suzanne Show. In this episode we discuss the key to optimized living, a healthy gut!

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: Gut health upcoming guest Thyroid underlying issues Nurse contracting Ebola from patient Should you get a flu vaccine?  

Pamela Wible, M.D., is a family physician whose pioneering model has been replicated nationwide. Her model is featured in Harvard School of Public Health’s Renegotiating Health Care, a textbook examining major trends with the potential to change the dynamics of health care. Dr. Wible is author of Pet Goats & Pap Smears, Amazon’s #1 top-rated medical e-book in 2013. Her essay on physician suicide in last month’s Washington Post was the third most read national news story of the day. Dr. Wible has been interviewed by CNN, ABC, CBS, and she is a frequent guest on NPR.

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's topics: Estrogen Dominance  Berkey Water Filters Ebola Articles: Artificial Sweetener  Hadza Man Stool Transplant

This week Dr. Dan and Kendall are joined by Jimmy Moore of Livin' La Vida Low Carb and author of the books, Cholesterol Clarity and Keto Clarity. Jimmy opens up about his long time struggle with obesity and the criticism he's received from the Paleo community. In this episode he talks about his health improving so much after he started a low carb diet that he was able to come off multiple medications. Check out this in depth conversation about the reality of obesity and the benefits of low carb diets. 

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's questions: 1. My thyroid reports have been normal every time my doc checks them but I have all the symptoms of thyroid problems is there something I am missing? 2. I am confused about whether I should be taking probiotics or not, no gut issues, advice? 3. What is the best source of protein powder and is NNU (net nitrogen utilization) a valuable guide?   4. I have heard all the talk about methylation and MTHFR, should I just go ahead and take methyl-folate, SAMe, NAC, and methyl-B12 and not worry about getting tested for the MTHFR?

Join us as we speak with neurosurgeon Jack Kruse. Dr. Kruse epitomizes the medical biohacker and he talks to us about the health risks with EMF (cell towers, cell phones, environmental) along with steps you can take to optimize your health. You will also learn about the benefits of cold thermogenesis, DHA fat, and reversing aging effects. He also reveals his most current and challenging biohack which he has been doing since January and the results are astonishing.  

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].    This week Dr. Dan is joined by Dr. Warren Walsh to answer questions related to exercise and fitness.

Bestselling visionary author, futurist, philosopher, and transhumanist this is Zoltan Istvan. His work has been featured by The New York Times Syndicate, Outside, San Francisco Chronicle, BBC Radio, NBC, ABC, CBS, FOX, Animal Planet, and the Travel Channel. He talks with Dr. Dan about the quest for human optimization and the drive for human or transhuman immortality. You do not want to miss this conversation.

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's questions and topics- "I’ve read some stuff on your website about the drawbacks and risks of oral estrogen, can you share more about this?" - Kim "My MCV (mean corpuscular volume) of my red cells keeps going up and I have heard you mention that this could be a marker for some nutrient deficiencies, what should I be taking to correct this?" - Jim Recent articles that we have posted on the Facebook page that are getting quite a bit of activity: - Caffeine is bad for you, really? - Marital satisfaction based on females happiness? There was another fascinating discovery mentioned in the news this week that is huge and few understand the true impact this has regarding longevity.

This week Darryl Edwards, The Fitness Explorer, joins Living The Optimized Life to chat with Dr. Dan and Kendall.  This week's topics: Kendall's experience taking Darryl's Primal Playout Workshop at the Ancestral Health Symposium Sleep hacking during travel Darryl's new projects Travel hacking "Health Unplugged" A one day Paleo conference in London October 25

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].    This week Dr. Dan is live from Italy explaining his take away after a week long Nutrigenomics course. 

This week's guest is Sami Inkinen, co-founder of Trulia, rowed across the pacific with his wife Meredith to bring awareness to the benefits of a high fat diet and the perils of sugar. Sami was inspired by the book Unbroken by Laura Hillenbrand to have an adventure in the name of awareness. Sami and Meredith created Fat Chance Row. They had no experience rowing yet rowed 2800 miles and broke a record to get to Hawaii in 45 days. Their experience was equal to running two marathons a day.    

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's questions:   1. What are your recommendations for natural ways to improve my ability to fall asleep, I will lay in bed for an hour at night trying to fall asleep, any suggestions would be appreciated.  - Melissa 2. Kendall - Our son who will be 6 in November, has had chronic diarrhea since the end of February.  We started with IgG testing which showed he is allergic/sensitive to many foods, including dairy, soy, gluten, almost all nuts (except walnuts), potatoes, coconut, lentils and a host of other things. We've known he has had a dairy and soy issue/intolerance/allergy since he was an infant (to cow, not goat).  We removed all foods that showed up on his IgG testing and two months later things were still the same. We've since done 3, 3 day stool samples that have been sent for testing and all have come back negative for everything - fungus, bacteria, parasites.  We have done a proactive 14 day course of Flagyl just in case. We've been to see the pediatric GI and an infectious disease doctor.  We've been to acupuncture.  He still has diarrhea - or I should say it ebbs and flows between a week of diarrhea and then soft stools.  The next step is to do a scope but we're trying to avoid that. We are pescatarians - so not paleo by a long stretch.  However, our pediatrician feels strongly that this is related to food and nutrition. 3. We have a question wondering why we talk about directed supplementation but we sell multi-vitamins on the site. What's up with that?

This week Dr. Dan and Kendall interview Perfect Health Diet co-author, Paul Jaminet, Ph.D. We discuss the book Paul and his wife, Shou-Ching Shih Jaminet, Ph.D. wrote about their experiments with low carn diets in 2005. They spent seven years refining them, have successfully healed their own "middle-age" and chronic health problems through diet, and have learned a great deal about the benefits-and pitfalls-of these diets that they now share in their book, The Perfect Health Diet.     

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's questions: I've recently ramped up my work outs and I've been eating a more balanced diet. Nothing extreme but cut processed foods and have been eating a lot of greens, lean meat and fruits. I still have a really bad sweet tooth I can't shake. I feel like it means something is off balance. What pointers can you offer about kicking the late night sugar cravings? -Megan   I have read about DEXA scans for measuring body fat, I saw on your website that you offer them and was wondering what is the best test to determine body fat percentage? - Nick   I am a middle aged guy but have been very athletic most of my life.  I have a naturally low VO2 max and I do not compete well in cross fit with others when we do metcons, is there a way to increase VO2 max? - Derrick   I am a 38 year old female and have been following a pale diet plan for several years, I have lost a good amount of weight but recently changed my exercise based on the advice of a friend - hoping to lose more weight.  I switched from mostly resistance training to more focus on aerobic, I have gained weight!  Help, what is the best exercise for weight loss? - Lauren

This week Kendall interviews Michelle Icard from Michelle in the Middle about her work empowering today's youth. Her second guest is Alessandra, The Foodie Teen. A 15 year old celiac in the UK who shares recipes and her journey of being a Paleo teen. 

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected].  This week's first question comes from Steve: Dr. Dan, I've been reading some new stuff on the benefits of slow carbs and would like to know your take on that.  The second topic of the show is the testing, diagnosis, and treatment options for the gene mutatiions MTHFR and COMT 

Join Dr. Dan and Kendall as we discuss "Cave Women Don't Get Fat," by Esther Blum.  This is a truly amazing book that covers not only the paleo diet but also the whole lifestyle associated with living an optimized life.  Her book delves into aspects that few of the paleo books touch on: sleep, stress, sex, and even hormones.  

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected]. This week we discuss our weekend in Berkeley, California for the Ancestral Health Symposium. We talk about the trending topiscs presented at AHS14.    

Every week Kendall and Dr. Dan answer your questions related to health, diet, sleep, wellness, functional medicine, age management, fitness, sexuality, hormones, balance, mindfulness, and much more. Send yours in to [email protected]. This week we talk about the release of our new website ephysiologix.com, our upcoming travels to the Ancestral Health Symposium in Berkeley, CA, and the big Jamaica Wellness Retreat we're hosting in Jamaica in October. We answer questions about jet lag, heavy cream usage, hashimotos and the Paleo diet, safe starches, and fish oil.