Each week, Dr. Mark Ebell, POEMs Editor, joins Dr. Michael Wilkes, NPR correspondent and Vice-Dean of the UC-Davis Medical School, for a five minute discussion about an important recent medical study reviewed by the POEMs editors. POEMs provide synopsised reviews of studies that could affect a clinician's practice, and the discussion in this podcast provides additional depth and insight into the issue covered by the POEMs synopsis. More about POEMs and it's companion point-of-care search tool, Essential Evidence Plus, at www.essentialevidenceplus.com.
Episode 695: Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms '
3/22/2024 • 11 minutes, 7 seconds
Episode 694: Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake '
3/20/2024 • 5 minutes, 56 seconds
Episode 693: Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease '
3/15/2024 • 6 minutes, 38 seconds
Episode 692: Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age '
3/11/2024 • 7 minutes, 8 seconds
Episode 691: High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization '
2/21/2024 • 5 minutes, 39 seconds
Episode 690: Delivery of bad news via phone = in-person delivery
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Delivery of bad news via phone = in-person delivery '
2/16/2024 • 6 minutes, 56 seconds
Episode 689: PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2) '
2/15/2024 • 6 minutes
Episode 688: Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones '
2/6/2024 • 5 minutes, 23 seconds
Episode 687: Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors '
2/5/2024 • 4 minutes, 37 seconds
Episode 686: ACC/AHA guideline for the management of patients with chronic coronary disease
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' ACC/AHA guideline for the management of patients with chronic coronary disease '
10/9/2023 • 6 minutes, 32 seconds
Episode 685: Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight '
10/2/2023 • 4 minutes, 37 seconds
Episode 684: Network meta-analysis: Limited data show that high-dose aspirin decreases incidence of colorectal cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Network meta-analysis: Limited data show that high-dose aspirin decreases incidence of colorectal cancer '
9/25/2023 • 6 minutes, 21 seconds
Episode 683: Cognitive behavioral therapy effective for patients with fatigue associated with long COVID
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cognitive behavioral therapy effective for patients with fatigue associated with long COVID '
9/18/2023 • 6 minutes, 39 seconds
Episode 682: The risk of breast cancer overdiagnosis is high for older women
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' The risk of breast cancer overdiagnosis is high for older women '
9/11/2023 • 6 minutes, 41 seconds
Episode 681: Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Esketamine is superior to quetiapine for remission of treatment-resistant depression (ESCAPE-TRD) '
9/4/2023 • 6 minutes, 54 seconds
Episode 680: Wrong blood pressure cuff size can falsely increase or decrease readings
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Wrong blood pressure cuff size can falsely increase or decrease readings '
8/28/2023 • 5 minutes, 5 seconds
Episode 679: Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early BP treatment for acute ischemic stroke has no impact on mortality or functional outcomes (CATIS-2) '
8/21/2023 • 7 minutes, 28 seconds
Episode 678: Acetaminophen and ketorolac are more effective than morphine in alleviating pain in adults with renal colic
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Acetaminophen and ketorolac are more effective than morphine in alleviating pain in adults with renal colic '
8/14/2023 • 5 minutes, 1 second
Episode 677: Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults '
8/7/2023 • 7 minutes, 43 seconds
Episode 676: Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL '
7/31/2023 • 5 minutes, 39 seconds
Episode 675: Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT) '
7/24/2023 • 6 minutes, 12 seconds
Episode 674: Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis '
7/17/2023 • 6 minutes, 3 seconds
Episode 673: Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing '
7/10/2023 • 6 minutes, 46 seconds
Episode 672: Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes '
7/3/2023 • 6 minutes, 7 seconds
Episode 671: Most people tolerate bedtime thiazide diuretics
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Most people tolerate bedtime thiazide diuretics '
6/26/2023 • 6 minutes, 22 seconds
Episode 670: Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER) '
6/19/2023 • 5 minutes, 59 seconds
Episode 669: Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms '
6/12/2023 • 6 minutes, 9 seconds
Episode 668: Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer '
6/5/2023 • 6 minutes, 19 seconds
Episode 667: Early return to activity improves symptoms in children with concussion
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early return to activity improves symptoms in children with concussion '
5/29/2023 • 4 minutes, 28 seconds
Episode 666: Tailored exercise program improves function and reduces pain due to knee osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tailored exercise program improves function and reduces pain due to knee osteoarthritis '
5/22/2023 • 6 minutes, 28 seconds
Episode 665: A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB) '
5/15/2023 • 7 minutes, 8 seconds
Episode 664: Older treatments for type 2 diabetes do not affect patient-oriented outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Older treatments for type 2 diabetes do not affect patient-oriented outcomes '
5/8/2023 • 5 minutes, 27 seconds
Episode 663: Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD) '
5/1/2023 • 6 minutes, 28 seconds
Episode 662: Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5) '
4/24/2023 • 7 minutes, 42 seconds
Episode 661: Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants '
4/17/2023 • 5 minutes, 43 seconds
Episode 660: Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR) '
4/10/2023 • 9 minutes, 42 seconds
Episode 659: Discectomy for sciatica provides short-term relief for leg pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Discectomy for sciatica provides short-term relief for leg pain '
4/3/2023 • 7 minutes, 44 seconds
Episode 658: Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT) '
3/27/2023 • 7 minutes, 26 seconds
Episode 657: Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND) '
3/20/2023 • 6 minutes, 41 seconds
Episode 656: Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain '
3/13/2023 • 4 minutes, 59 seconds
Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '
3/6/2023 • 6 minutes, 33 seconds
Episode 654: Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome '
2/27/2023 • 4 minutes, 31 seconds
Episode 653: Brief behavioral therapy diminishes insomnia in the elderly
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brief behavioral therapy diminishes insomnia in the elderly '
2/20/2023 • 5 minutes, 54 seconds
Episode 652: Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder '
2/13/2023 • 7 minutes, 16 seconds
Episode 651: No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF) '
2/6/2023 • 5 minutes, 27 seconds
Episode 650: Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients '
1/30/2023 • 8 minutes, 38 seconds
Episode 649: Chlorthalidone no better than hydrochlorothiazide for hypertension
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Chlorthalidone no better than hydrochlorothiazide for hypertension '
1/23/2023 • 6 minutes, 26 seconds
Episode 648: Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT) '
1/16/2023 • 6 minutes, 34 seconds
Episode 647: Tell patients their new knee won't wear out sooner with hard use
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tell patients their new knee won't wear out sooner with hard use '
1/9/2023 • 7 minutes, 33 seconds
Episode 646: Majority of CIN2 regress in women aged 25 to 30 years
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Majority of CIN2 regress in women aged 25 to 30 years '
1/2/2023 • 6 minutes, 8 seconds
Episode 645: Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME) '
12/26/2022 • 5 minutes
Episode 644: Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes '
12/19/2022 • 7 minutes, 8 seconds
Episode 643: Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC) '
12/12/2022 • 7 minutes, 17 seconds
Episode 642: Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy '
12/5/2022 • 5 minutes, 20 seconds
Episode 641: Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure '
11/28/2022 • 5 minutes, 4 seconds
Episode 640: Rebound symptoms common with COVID-19 even after placebo treatment
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rebound symptoms common with COVID-19 even after placebo treatment '
11/21/2022 • 5 minutes, 42 seconds
Episode 639: Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities '
11/14/2022 • 6 minutes, 23 seconds
Episode 638: Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35%
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35% '
11/7/2022 • 5 minutes, 59 seconds
Episode 637: Nonpharmacologic approaches can improve fibromyalgia symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nonpharmacologic approaches can improve fibromyalgia symptoms '
10/31/2022 • 4 minutes, 44 seconds
Episode 636: Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better '
10/24/2022 • 5 minutes, 35 seconds
Episode 635: Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin '
10/17/2022 • 7 minutes, 8 seconds
Episode 634: Polypill better for secondary cardiovascular prevention than physician-directed care
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Polypill better for secondary cardiovascular prevention than physician-directed care '
10/10/2022 • 7 minutes, 39 seconds
Episode 633: Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear '
