This episode was recorded before 31 July 2024. Professor Marcus Maurer, Dr Carolina Vera Ayala, and Associate Professor Jonny Peter discuss how new therapeutics progress through the development pipeline, noting the “huge amount of data” required on safety before a molecule enters clinical trials. They also shed light on drug repurposing and why children are a “critical group” for inclusion in trials. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Chronic urticaria: unmet needs, emerging drugs, and new perspectives on personalised treatment Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

[This episode was recorded before 31 July 2024.] "Every chronic urticaria starts as acute urticaria, but not every acute urticaria becomes chronic." Associate Professor Dr Andaç Salman and Professor Marcus Maurer discuss causes of acute urticaria, how diagnosis and management can be improved, and UCARE’s research into drivers of “chronification”. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Acute and chronic urticaria diagnosis and management taking into account their differences; Acute urticaria – GA2LEN UCARE 2023 conference presentation and Project: CHAPEAU – GA2LEN UCARE Network Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

This episode was recorded before July 31, 2024. Professor Marcus Maurer and Dr Sigurd Broesby-Olsen discuss similarities and differences between urticaria and mastocytosis, two mast cell diseases. They then turn their attention to treatment, sharing their thoughts on ‘killing’ mast cells and the development of more targeted and less toxic therapies. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell-mediated diseases; Mast cell–targeting therapies in mast cell activation syndromes; and Tyrosine kinase inhibitors for the treatment of indolent systemic mastocytosis: Are we there yet? Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

"We will only be able to cure this disease and treat it well if we know how it works." Back by popular demand, Dr Jörg Scheffel rejoins Professor Marcus Maurer to discuss the importance and intricacies of mast cell research in urticaria.” Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; and Isolation and Culture of Human Skin Mast Cells. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

Dr Maryam Ali Al-Nesf joins Professor Marcus Maurer to discuss one of the big burdens of chronic urticaria: the "use, or should we say abuse, of cortisone" in chronic spontaneous urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Efficacy and safety of systemic corticosteroids for urticaria: A systematic review and meta-analysis of randomized clinical trials; and A patient charter for chronic urticaria. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Christian Vestergaard and Professor Marcus Maurer discuss the link between obesity and urticaria, including how obesity contributes to chronic inflammation and the importance of P4 medicine (preventive, predictive, personalised, participatory) in urticaria treatment.  Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria; and Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer and Professor Martin Metz reflect on the European Academy of Allergy and Clinical Immunology (EAACI) congress 2024, including novel treatments on the horizon, key takeaways and expectations for future meetings.  Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Remibrutinib demonstrates favourable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks; and European Medicines Agency approved indications for omalizumab biosimilar. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer welcomes Dr Jörg Scheffel to discuss urticaria, including techniques used to interrogate mast cells and examine interstitial fluid, and a technique used to identify autoimmune-mediated forms of urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Chronic urticaria and the pathogenic role of mast cells; A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Episode 89 – Professor Elias Toubi joins Professor Marcus Maurer to discuss remission in urticaria, including its definition and possible risk factors for long disease duration.

Associate Professor Elena Borzova joins Professor Marcus Maurer to discuss exercise as a trigger for urticaria in some athletes, including the paradoxical protective effect of exercise in people with urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Exercise-induced urticaria: A rare case report; and Physical activity and mental health among patients with atopic dermatitis or chronic spontaneous urticaria: A cross-sectional study. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer welcomes Dr Carolina Vera Ayala and Associate Professor Jonny Peter to discuss participation in clinical trials for urticaria, including patient concerns around placebo treatment. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: What is clinical research and why is it done?  Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer welcomes Professor Philip Li to discuss the management of urticaria in Hong Kong, including access to effective treatments and socioeconomic and cultural factors. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Hong Kong–Macau severe hives and angioedema referral pathway, Disparities in chronic spontaneous urticaria: Eligibility for drug reimbursement associated with clinical outcomes, Chronic spontaneous urticaria in Hong Kong: Clinical characteristics, real-world practice and implications for COVID-19 vaccination Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Dr Jason Hawkes joins Professor Marcus Maurer to discuss dermatologists’ lack of urticaria knowledge, including tips on encouraging the US dermatology community to use resources such as the CRUSE app. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Key messages: Urticaria guidelines; Urticaria: A comprehensive review and Hives: Diagnosis and treatment. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“This is a global problem that requires global solutions, but I think they do come from what we learn in our settings.” Professor Marcus Maurer welcomes Dr Clive Grattan to discuss the differences in the treatment and management of urticaria across the UK and Germany, including guideline recommendations and new treatments on the horizon. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: British Association of Dermatologists guidelines for the management of people with chronic urticaria 2021 and The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“I think CARE will grow and grow.” Dr Thomas Buttgereit joins Professor Marcus Maurer to discuss the recently launched Chronic Angioedema Registry (CARE), including benefits for patients, current capabilities and how to get involved. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: Chronic Angioedema Registry. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“There’s still so much we need to learn.” Dr João Marcelino joins Professor Marcus Maurer to discuss autoimmune chronic spontaneous urticaria, including indicative test results and hopes for the future. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: What basophil testing tells us about CSU patients – results of the CORSA study, Autologous serum skin test reactions in chronic spontaneous urticaria differ from heterologous cell reactions and Omalizumab in chronic spontaneous and inducible urticaria: A 9-year retrospective study in Portugal. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“It’s really a catalyst to what the network does.” Professor Marcus Maurer asks Dr Luis Felipe Ensina to reflect on the UCARE Conference 2023, covering personal highlights and expectations for future meetings. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: UCARE Conference 2023. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“It doesn’t just affect one part of your life.” Arzoo Ahmed joins Professor Marcus Maurer to discuss the patient perspective, covering the reality and challenges of living with chronic spontaneous urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: Our Future Health. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“This is only the beginning of making use of this technology.” Professor Marcus Maurer is joined by asthma and allergic rhinitis expert Professor Jean Bousquet to discuss the collaboration that produced the MASK-Air and CRUSE apps, how they are helping Ukrainian refugees and the possibilities for future development. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: Digitally enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air® approach; MASK-Air app and UCRAID (Ukrainian Citizens and Refugees help in respiratory, Allergy, Immunology, and Dermatology). Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“Wouldn’t it be nice to find a cure?” Professor Marcus Maurer is joined by Dr Aurélie Du-Thanh to discuss cold urticaria, covering risk factors, diagnosis journey, and the most suitable treatment options. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: Urticaria Group of the French Society of Dermatology, Vibratory urticaria associated with a missense variant in ADGRE2 and Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

“We treat until it’s gone.” Professor Marcus Maurer is joined by Professor Gordon Sussman to discuss the use of antihistamines in people with urticaria, covering the history, side effects, safety and best practices. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links and access additional resources relating to the topics discussed in this episode: Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials and Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria.

Professor Marcus Maurer is joined by Clinical Nurse Specialist Lorena Lorenzo to discuss the responsibilities of the nurse’s role, and the potential benefits it brings for people living with urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Immunology nursing competency framework and a sponsored article: When is swelling not an allergy? Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

In response to listener requests, Professor Marcus Maurer is joined by veterinary specialist Professor Ralf Mueller to discuss how urticaria affects animals, including similarities and differences with the condition in humans and the challenges of treating performance animals. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Triggers, risk factors and clinico-pathological features of urticaria in dogs – a prospective observational study of 24 cases and Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Riccardo Asero joins Professor Marcus Maurer to offer advice on the use of non-steroidal anti-inflammatory drugs (NSAID) in people with chronic spontaneous urticaria (CSU). The experts discuss risk assessment and strategies to avoid respiratory and cutaneous hypersensitivity reactions in people who require these common medications to manage comorbidities. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Nonsteroidal anti-inflammatory drugs hypersensitivity in chronic spontaneous urticaria in the light of its pathogenesis and Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer is joined by Professor Eduardo Souza Lima to explore the relationship between stress and urticaria, and the implications of mast cells and neuropeptides in chronic spontaneous urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Neuro-Immuno-Psychological Aspects of Chronic Urticaria, Expression of Hypothalamic-Pituitary-Adrenal Axis in Common Skin Diseases: Evidence of its Association with Stress-related Disease Activity, Psychological Stress and Chronic Urticaria: A Neuro-immuno-cutaneous Crosstalk. A Systematic Review of the Existing Evidence, Exaggerated Neurophysiological Responses to Stressor in Patients with Chronic Spontaneous Urticaria, Disease Activity and Stress are Linked in a Subpopulation of Chronic Spontaneous Urticaria Patients and High Prevalence of Mental Disorders and Emotional Distress Patients with Chronic Spontaneous Urticaria. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Dermatologist Professor Kiran Godse joins Professor Marcus Maurer to explore the use of JAK and STAT inhibitors in the management of chronic urticaria and how these drugs may impact quality of life for people with this condition. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Role of IL-9 and IL-10 in the pathogenesis of chronic spontaneous urticaria through the JAK/STAT signalling pathway and Efficacy of Oral Ruxolitinib in a Patient with Refractory Chronic Spontaneous Urticaria. Access additional resources by signing up to Medthority (ATU tab link) and to be notified for future 'All Things Urticaria' podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Marcus Maurer is joined by the president of Global Allergy & Airways Patient Platform (GAAPP), Tonya Winders, for a special Urticaria Day (UDAY) episode to discuss the role patient advocacy groups play in supporting individuals with chronic spontaneous urticaria. Both experts explore patient unmet needs and highlight methods clinicians can use to help overcome these barriers. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external link to access additional resources relating to the topics discussed in this episode: Global Allergy & Airways Patient Platform. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry)

Dr Désirée Larenas-Linnemann and Professor Marcus Maurer delve into best practices for urticaria management in resource-poor settings, underlining the crucial role of accurate diagnosis and adherence to established guidelines. They also address trending topics in angioedema and urticaria treatment, such as antihistamine up-dosing and the complexities surrounding triple-combination therapies and the need for better education. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here: Utilise the following external links to access additional resources relating to the topics discussed in this episode:  Mexican Guide to the Diagnosis and Treatment of Urticaria | Allergy Magazine Mexico (revistaalergia.mx), https://ga2len-ucare.com/Urticaria Control Test (Survey), Urticaria.net, Urticaria Test Selection and the MOXIE Website Access additional resources by signing up to Medthority (ATU tab link) and to be notified for future 'All Things Urticaria' podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry)

Professor Marcus Maurer is joined by Professor Paula Busse to explore the multifaceted burdens of angioedema for patients and physicians. They discuss issues surrounding timely diagnosis, interpreting ambiguous symptoms, patient concerns about medications, and enhancing quality of life monitoring. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Assessment of disease activity and quality of life in patients with recurrent bradykinin-mediated versus mast cell-mediated angioedema, The international WAO/EAACI guideline for the management of hereditary angioedema – The 2021 revision and update and the CARE Registry. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Dr Régis de Albuquerque Campos joins Professor Marcus Maurer to discuss the implications of angioedema and its impact on people living with chronic spontaneous urticaria (CSU). Dr Campos highlights diverse aspects of the burden of CSU and the impact misdiagnosis has on quality of life. Professor Maurer provides an overview of the current treatment landscape, differential diagnosis, unmet needs in angioedema clinical trials and the utilisation of omalizumab in managing angioedema associated with CSU. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: A Comprehensive Review of Bradykinin-Induced Angioedema Versus Histamine-Induced Angioedema in the Emergency Department, Isolated angioedema: A review of classification and update on management and The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Markus Magerl joins Professor Marcus Maurer in this episode to explore the significance of differential diagnosis in the identification of angioedema in chronic spontaneous urticaria (CSU). Professor Magerl takes a deep dive into the prospective use of artificial intelligence (AI) in the analysis of data derived from a questionnaire utilising algorithmic models. Both professors, Maurer and Magerl, discuss the implications AI can have in enhancing the diagnostic accuracy of angioedema. Utilise the following external links to access additional resources relating to the topics discussed in this episode: 10 Questions - Using AI for diagnosing your or your patient´s angioedema, Differences and Similarities in the Mechanisms and Clinical Expression of Bradykinin‑Mediated vs. Mast Cell–Mediated Angioedema and Case Report: Recurrent Angioedema: Diagnosing the Rare and the Frequent. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Marcus Maurer is joined by Dr Aistė Ramanauskaitė to explore the CRUSE app's potential advantages for individuals suffering from chronic spontaneous urticaria. Professor Maurer emphasises the importance and utilisation of the CRUSE app, while Dr. Ramanauskaitė delves into the various benefits and practical applications offered by the app. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external link to access additional resources relating to the topics discussed in this episode: UCARE YouTube Channel. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Martin Metz joins Professor Marcus Maurer to answer an audience proposed question focusing on what will guide physicians in the recommendations for individual patients to identify the most beneficial treatment option to treat chronic spontaneous and inducible urticaria. Both experts delve into the current treatment options available, and exciting treatments that are currently in clinical trials. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Utilise the following external links to access additional resources relating to the topics discussed in this episode: Dupilumab in CSU, Remibrutinib in CSU, Bruton's tyrosine kinase inhibition—An emerging therapeutic strategy in immune-mediated dermatological conditions, An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria, Barzolvolimab in mast cell depletion, Chronic spontaneous urticaria: Focus on pathophysiology to unlock treatment advances, Chronic urticaria and the pathogenic role of mast cells and Urticaria (an overview). Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Marcus Maurer is joined by GP Dr Dermot Ryan to discuss the role of GPs in the diagnosis and management of chronic urticaria. Professor Maurer and Dr Ryan highlight the positive impact that physicians have in limiting patient distress while increasing patient confidence, despite the time-limited interactions. They also explore the impact of mistreatment on a patient’s life.   Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.     For more information on all UCARE activities please visit: Home - UCARE and utilise the following external links to access additional resources relating to the topics discussed in this episode:  The UCARE centres , UCARE LevelUp and 4U, CRUSE Control App, The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition and Clinical review: The suggested management pathway for urticaria in primary care.  Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!   For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Marcus Maurer asks Dr Sherezade Moñino-Romero about her research into soluble IgE receptor and its potential as a marker of treatment response in chronic urticaria. They also discuss the art of communicating science to the public and why it is so vital to do it effectively. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. For more information on all UCARE activities please visit: https://ga2len-ucare.com/ and utilise the following external links to access additional resources relating to the topics discussed in this episode: Positive basophil tests are linked to high disease activity and other features of autoimmune chronic spontaneous urticaria: A systematic review, Total IgE as a Marker for Chronic Spontaneous Urticaria and Soluble IgE-binding factors in the serum of food-allergic patients: Possible pathophysiological role of soluble FcεRI as protective factor. Follow Sherezade’s work on her website and socials via the following links: Twitch, Twitter, TikTok and YouTube. For more information about the UCARE/ACARE network and its activities please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry

Professor Marcus Maurer is accompanied by Professor Marc Riedl to delve into the symptomatology and pathophysiology of angioedema in chronic spontaneous urticaria (CSU). The mechanistic aetiology of angioedema within the context of CSU pathology is also explored. Professor Marc Riedl examines therapeutic treatments for patients concurrently experiencing angioedema in CSU while exploring how the characterisation of autoimmune and auto allergic pathophysiological mechanisms can impact treatment decisions. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. For more information on all UCARE activities please visit: https://ga2len-ucare.com/ and utilise the following external links to access additional resources relating to the topics discussed in this episode: Angioedema - Ten Questions, Differences and Similarities in the Mechanisms and Clinical Expression of Bradykinin-Mediated vs. Mast Cell–Mediated Angioedema, WAO/EAACI guideline for HAE, The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria, and Consensus on treatment goals in hereditary angioedema.

Professor Karla Arruda and Professor Marcus Maurer discuss the development and implementation of UCARE in Brazil, and its potential benefits for individuals suffering from chronic spontaneous urticaria (CSU). The conversation extends towards exploring the framework of the Brazilian UCARE centres and projects, and how it can be implemented in other countries. Professor Maurer delves into the clinical efficacy, advantages, and impact on patient quality of life of utilising Bruton’s tyrosine kinase inhibitors for the treatment of CSU, along with further discussion of alternative treatments. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  Do you have suggestions for future episodes? Please visit UCARE to provide feedback via the link here and offer your suggestions for future topics and expert selection!

Professors Marcus Maurer and Luis Felipe Ensina deliberate on the most recent findings that emerged at The American Academy of Allergy, Asthma & Immunology (AAAAI) conference held in San Antonio, Texas. In particular, Professor Maurer discusses poster presentations concerning the efficacious use of omalizumab and dupilumab for the management of urticaria. Professor Ensina expands the discussion by outlining ongoing projects and upcoming projects within UCARE that will be presented at the forthcoming UCARE conference in São Paulo in 2023. Access additional resources by signing up to Medthority and to be notified for future 'All Things Urticaria' podcast episodes!  Do you have suggestions for future episodes? Please visit UCARE to provide feedback via the link here and offer your suggestions for future topics and expert selection!

Dr. Murat Türk has joined Professor Marcus Maurer to discuss biomarkers in chronic spontaneous urticaria (CSU), focusing on immunoglobulin E (IgE) in particular. They emphasise the importance of using IgE testing appropriately in the treatment of CSU; as a prognostic parameter rather than a diagnostic technique. The discussion expands into a comparison between basophil testing and IgE testing and explores the implications of these results for patients with CSU.

Professor Marcus Maurer is joined by Dr Melba Munoz to take a deep dive into symptomatic dermographism. The discussion aims to explain the involvement of mast cells in CSU patients and attempts to answer some ongoing questions to help unravel the pathogenesis of dermographism in chronic urticaria.

Dr Pavel Kolkhir joins Professor Marcus Maurer to discuss the Chronic Urticaria Registry (CURE). The discussion includes explanations of the aims of CURE in collecting quality, real-life data on chronic urticaria patient characteristics, the course of disease, underlying causes, comorbidities, treatment responses, quality of life impairment and health care costs.

Professor Marcus Maurer is joined by Dr Jie Li to discuss the role  the gut microbiome plays in the disease progression of CSU. A particular focus is given to metabolism and homeostasis in patients with CSU, how the gut microbiome can impact CSU presentation, and the impact it can have on the efficacy of treatments such as antihistamines.

Professor Alicja Kasperska-Zajac joins Professor Marcus Maurer to discuss a rare form of chronic inducible urticaria – delayed pressure urticaria. The discussion highlights the difficulties in undertaking differential diagnosis and the main differences when compared to chronic spontaneous urticaria, namely the absence of oedema and wheals. 

Professor Yoshimichi Okayama joins Professor Marcus Maurer to discuss the role which mast cells play in the disease aetiology of chronic spontaneous urticaria. In particular, the discussion focuses on mast cell receptors and how they can be utilised in the diagnosis of CSU.

Professor Marcus Maurer is joined by Professor Asli Gelincik as they discuss recurrent angioedema in chronic spontaneous urticaria, and treatment options which are currently available to alleviate this pathology. The mechanistic actions of mast cell-mediated angioedema and bradykinin-mediated angioedema are discussed and their implications are analysed.

Dr Heike Röckmann, head of the drug survivability of omalizumab in chronic urticaria (DruSO-CU) project joins Professor Marcus Maurer to discuss the global project, the difficulties which were encountered, and how the UCARE network helped overcome these challenges. The focus of this podcast is on the importance of identifying the data in this important project.

In this episode, Professor Silvia Ferrucci joins Professor Marcus Maurer in discussing what the phrase ‘Never Give Up’ means to physicians treating urticaria, and for patients embarking on their treatment journey. Areas of special focus are given to guideline treatment algorithms and the implementation of the CRUSE app and Chronic Urticaria Registry (CURE) as tools to shift the balance of treating urticaria.

Professor Marcus Maurer is joined by Professor Luis Felipe Ensina where they discuss the founding days of urticaria treatment, and how urticaria clinics became available. Professor Maurer and Professor Ensina discussed how the treatment landscape, diagnostic techniques and further developments in the advancement of how clinicians treat patients with urticaria have evolved over the last two decades.

Professor Anna Zalewska-Janowska joins Professor Maurer to delve into fascinating area of psycho-neurodermatology and how this can impact the lives of individuals with urticaria. Prof. Zalewska-Janowska highlights the importance of how urticaria is linked to neurogenic inflammation in chronic urticaria.

In this episode Professor Marcus Maurer is joined by patient and patient advocate Elaine, who experiences chronic urticaria. She highlights the importance of connecting patients with each other, and discusses the opportunities that arise when patients work together with healthcare professionals.

Dr Sinisa Savic joins Professor Dr Marcus Maurer in this podcast to discuss chronic urticarias and systemic auto-inflammatory syndromes, delving into differential diagnostic techniques and utilisation of genetics to determine causation of clinical presentations.

During this episode, Professor Marcus Mauer is joined by Dr Zuotao Zhao of Beijing Medical University, China, to discuss the growing problem of chronic spontaneous urticaria within the Chinese population and delve into possible causes of such a high incidence.

Professor Marcus Mauer is joined by Dr Murat Türk and Dr Ragıp Ertaş of UCARE in Turkey to discuss advancements in the treatments of urticaria, with a special focus on the implementation of artificial intelligence and machine learning.

Prof. Emek Kocatürk joins Professor Marcus Mauer in this episode of All Things Urticaria to discuss the effects of the COVID 19 pandemic on CSU patients, and how COVID 19 vaccines impacted the exasperation of chronic spontaneous urticaria as part of the COVAC-CU study.

Hear Associate Professor Jonathan Peter (Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, South Africa; Allergy and Immunology Unit, University of Cape Town Lung Institute, South Africa) explain regional differences in urticaria in South Africa, with a focus on epidemiology, patient beliefs and education, and the CRUSE App

In this episode, Dr Maximiliano Gómez shares his tips and tricks for improving the diagnosis and management of chronic urticaria and calls for wider dissemination of good quality information to patients living in Argentina and beyond.

Dr Mona Al-Ahmad joins the podcast from the UCARE centre in Kuwait to share her insights into the UCARE network’s Middle Eastern activities. Dr Al-Ahmad also takes time to reflect on what more can be done to improve the lives of people living with chronic urticaria and those caring for them.

In this episode, our host is joined by Professor Kiran Godse who shares his experiences of treating CSU in India. Professor Godse provides unmissable insights into the practicalities of CSU care, including economic considerations, as well as his plans to increase the UCARE network’s presence in India and facilitate wider dissemination of educational resources.

Professor Jonathan Bernstein joins the podcast to discuss chronic urticaria (CU) care in the USA. In this episode, Professor Bernstein shines a light on the challenges faced by US-based physicians and highlights the potential benefits of conducting further research into the diverse population living with CU in North America.

In part two of this very special episode, Professor Marcus Maurer is joined once again by his colleagues from the UCARE office to discuss the UCARE LevelUp and UCARE 4U programmes, which aim to inform and educate patients and physicians on the management of chronic urticaria. To find out more information on UCARE, please visit ga2len-ucare.com.

In this very special two-part episode, Professor Marcus Maurer is joined by not one, but four of his UCARE office colleagues to give listeners exclusive insight into the inner workings of the UCARE network, including advice on how to become a UCARE centre and updates on exciting new UCARE initiatives.

In this episode, our host is joined by Dr Christian Vestergaard, who offers expert insight into the results of the AWARE study and highlights the urgent need for wider dissemination of the guidelines for CSU management.

In this episode, Dr Sophia Neisinger joins the podcast to introduce the CRUSE CONTROL app, which has been developed to help support chronic spontaneous urticaria self-evaluation and aims to improve patient quality of life. 

In this episode, Dr Désirée Larenas-Linnemann joins our host to discuss the importance of providing better education on urticaria for patients and physicians around the world. Dr Larenas-Linnemann also highlights international differences in educational needs and the role of UCARE programmes in addressing these.

Dr Vicky Xepapadaki joins the podcast to share her knowledge of paediatric urticaria, including current treatment strategies and unmet needs.

In this episode, Dr Iman Nasr discusses UCARE LevelUp, an educational program devised by the UCARE network to allow healthcare professionals to learn, network and share best clinical practices in chronic urticaria. Dr Nasr also touches on UCARE 4U, the UCARE patient information and education platform and programme.

In this episode, Dr Ana Gimenez discusses new insights into the pathology of chronic urticaria and how these insights can help guide treatment decisions. Dr Gimenez discusses the inflammatory mediators relevant in chronic urticaria, with a particular focus on platelet-activating factor (PAF). She describes the role of PAF, its contribution to the development of signs and symptoms of chronic urticaria, and why she considers PAF an important consideration in chronic spontaneous urticaria.

In this episode, photodermatology expert, Professor Lesley Rhodes, sheds light on one of the rarer forms of chronic inducible urticaria: solar urticaria. This includes a practical guide to diagnosis and referral, as well as a summary of the unmet needs that remain in the management of this understudied condition.

In this episode, paediatric urticaria expert and UCARE driving force, Professor Petra Staubach-Renz reflects on her experience of treating children with chronic urticaria and calls for more research into this important yet understudied group of patients.

Does our current understanding of the pathogenesis of CSU provide hope of a cure for this challenging disease? Find out what Dr Riccardo Asero has to say as he joins our host to discuss some of the most fundamental questions in the field of urticariology.  

It is well known that chronic urticaria is more common in women than men, but why is this the case? In this episode, our expert guest, Professor Laurence Bouillet, explores gender-based differences in this disease.

Are you familiar with Angioedema Centers of Reference and Excellence (ACARE)? In this episode, our host is joined by Dr Anete Grumach, to celebrate the recent successes of the ACARE network and discuss the future of this exciting initiative.

In this episode, our host is joined by Dr Caroline Mann, an urticariologist and sleep expert, who highlights the profound impact of sleep disturbance on quality of life in patients with urticaria and explains what can be done to address this common, but often overlooked aspect of the disease. 

In this episode, our host is joined by Dr Ivan Chérrez Ojeda, an urticariologist and communication technology enthusiast, to discuss the potential application of telemedicine in the management of patients with chronic urticaria.  

Could targeting cytokines produced by autoreactive T cells benefit patients with chronic spontaneous urticaria (CSU)? Professor Marcus Maurer is joined by Professor Elias Toubi to discuss the role of T cells in CSU.

In this episode, Dr Young-Min Ye shares the findings of her cutting-edge research into predictors of remission in chronic urticaria, and explains what is currently known about the role of Mas-related G protein coupled receptor X2 (MRGPRX2) in the activation of mast cells. 

How do comorbidities affect patients with chronic spontaneous urticaria and what can be done to minimise their impact? Find out more on this crucial, yet understudied topic from our latest guest, Dr Simon Francis Thomsen. 

In this episode, our host is joined by Dr Moshe Ben-Shoshan, who shares his pioneering approach to treating paediatric patients and draws on his experience to debunk some of the common myths surrounding childhood urticaria. 

In this episode, our host is joined by UK-based dermatologist Dr Clive Grattan to address some of the most important unanswered questions in the field of chronic spontaneous urticaria.

In this very special episode, our host meets Cassandra, a patient who has been affected by CSU for many years. Listen now for unmissable insights into the patient experience and to find out more about what you do to better support your own patients in the future. 

Did you know 12-20% of the population will experience acute urticaria sometime in their lifetime? In this episode, Dr Angèle Soria explains the differences between acute urticaria and other urticarias, how to manage the condition and what to look out for and highlights her most recent publication.

Did you know that not all patients with CSU develop wheals? In this episode, Professor Connie Katelaris explains the unique challenges physicians face when diagnosing and managing CSU patients who have pure angioedema without wheals, and offers advice on how to spot pseudoangioedema.

For those just starting out on their UCARE journey, the extensive list of criteria can seem daunting. In this episode, our host is joined by Professor Kanokvalai Kulthanan, who offers her advice on tackling the application process.  

Since its inception in 2018, COLD-CE has collected data on hundreds of patients with cold urticaria from around the world. In this episode, Dr Mojca Bizjak reflects on her experience of running a UCARE project, offering insight and advice for those hoping to do so in the future. 

Despite affecting up to 5% of the population, symptomatic dermographism remains understudied. Discover more about how our ability to diagnose and treat this common and debilitating condition is improving from urticaria expert, Dr Tomasz Hawro. 

Dr Frank Siebenhaar brings us up to date on the differences between mastocytosis, urticaria and mast cell activation syndrome (MCAS). He also introduces CSUplus, an ongoing UCARE project that aims to shed light on the extracutaneous symptoms of chronic spontaneous urticaria.

Dr Jorge Sánchez reflects on how it felt to give himself urticaria and explains what his bold experiment has taught us about the role of anti-TPO IgE in this disease.

Angioedema expert and ACARE founding father, Professor Markus Magerl, joins Professor Marcus Maurer to discuss all things angioedema and get the latest on the ever-growing ACARE network. 

Professor Marcus Maurer is joined by Dr Emek Kocatürk Göncü who addresses concerns regarding the impact of COVID-19 infection in patients with chronic urticaria and summarises the results of the recent UCARE project, PREG-CU.

Professor Martin Church reflects on the enormous progress that has been made in the field of urticariology and discusses what is yet to come for patients with this devastating disease. This episode is for health care professionals only

Professor Marcus Maurer is joined by “UCARE father”, Dr Luis Felipe Ensina, to discuss the frequently underestimated burden of urticaria, which Dr Ensina explains is not limited to the patients themselves, but may indirectly impact numerous friends and family members as well.

With the sixth consensus meeting on the EAACI/GA2LEN/EDF/WAO guideline for urticaria fast approaching, Professor Marcus Maurer is joined by Professor Torsten Zuberbier, who explains what you can expect from this new edition.  This episode is intended for registered Healthcare Professionals only.

Cold urticaria expert, Dr Dorothea Terhorst-Molawi, and host, Professor Marcus Maurer, discuss the complexities of this highly heterogenous condition and explain why they are optimistic about what the future holds for those affected. This episode is intended for registered Healthcare Professionals only.

In cholinergic urticaria, symptoms may arise as a result any activity that induces sweating. In this episode, Professor Marcus Maurer is joined by cholinergic urticaria expert, Dr Sabine Altrichter, who provides insight into what is currently known about this debilitating condition. This episode is intended for registered Healthcare Professionals only.

Professor Marcus Maurer is joined by Patient-reported outcome measures (PROMs) expert, Professor Karsten Weller, who explains that while such tools are essential to improve the management of urticaria, they can be challenging to develop. This episode is intended for registered Healthcare Professionals only.  

Professor Marcus Maurer is joined by itch expert, Professor Martin Metz, who explains that itch is much more than just “the little brother of pain” and describes the research that is currently underway to improve our understanding of this debilitating symptom. This episode is intended for registered Healthcare Professionals only.

Professor Marcus Maurer is joined by UCARE cofounder, Professor Ana Giménez-Arnau, to discuss the history of the UCARE network and offer practical advice to those seeking to become a member. This episode is intended for registered Healthcare Professionals only.

Introduction to the UCARE podcasts. This episode is intended for registered Healthcare Professionals only.